Association between ADORA2A gene polymorphisms and schizophrenia in the North Chinese Han population

Junxiao Miao,1,* Lu Liu,1,2,* Ci Yan,1 Xiaotong Zhu,1 Mengqi Fan,1 Peitong Yu,1 Keming Ji,1 Yinglin Huang,3 Yuan Wang,3 Gang Zhu11Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of China; 2Department of Psychi...

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Autores principales:	Miao J, Liu L, Yan C, Zhu X, Fan M, Yu P, Ji K, Huang Y, Wang Y, Zhu G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	adenosine A2A receptor gene polymorphisms schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/bb31a15c4c0142799ab4efd49b684d57
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spelling	oai:doaj.org-article:bb31a15c4c0142799ab4efd49b684d572021-12-02T10:02:33ZAssociation between ADORA2A gene polymorphisms and schizophrenia in the North Chinese Han population1178-2021https://doaj.org/article/bb31a15c4c0142799ab4efd49b684d572019-08-01T00:00:00Zhttps://www.dovepress.com/association-between-adora2a-gene-polymorphisms-and-schizophrenia-in-th-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Junxiao Miao,1,* Lu Liu,1,2,* Ci Yan,1 Xiaotong Zhu,1 Mengqi Fan,1 Peitong Yu,1 Keming Ji,1 Yinglin Huang,3 Yuan Wang,3 Gang Zhu11Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of China; 2Department of Psychiatry, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, People’s Republic of China; 3Department of Psychiatry, Shengjing Hospital of China Medical University, Shenyang 110020, People’s Republic of ChinaCorrespondence: Gang ZhuDepartment of Psychiatry, the First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of ChinaTel/Fax +86 248 328 2184Email gzhu@cmu.edu.cn*These authors contributed equally to this workBackground: A large number of studies have shown a close relationship between ADORA2A and the pathological mechanism of schizophrenia. However, to our knowledge, there has been no studies examining the association between the ADORA2A gene and schizophrenia in Chinese Han population.Purpose: The objective of this study was to examine the relationship between adenosine A2A receptor (ADORA2A) single nucleotide polymorphisms and schizophrenia in the North Chinese Han population.Patients and methods: We detected ADORA2A single nucleotide polymorphisms (SNPs) using polymerase chain reaction-restriction fragment length polymorphism analyses and summarized our results using SPSS statistical software and Haploview in schizophrenia case group (n=398) and healthy control group (n=535).Results: The frequency of the CC homozygote genotype of SNP rs2298383T/C were significantly higher in the case than the control group (p=0.005, OR=1.712, 95% CI=1.172–2.502). After linkage disequilibrium analysis, SNPs rs5996696A/C and rs2298383T/C displayed strong linkage disequilibrium. We found that the frequencies of haplotypes TA (χ2=6.268, p=0.0123) and CA (χ2=7.012, p=0.0081) were significantly higher in the case group than in the control group.Conclusion: In conclusion, SNPs in the ADORA2A gene may be associated with schizophrenia in the northern Chinese Han population.Keywords: ADORA2A, gene polymorphisms, schizophreniaMiao JLiu LYan CZhu XFan MYu PJi KHuang YWang YZhu GDove Medical Pressarticleadenosine A2A receptorgene polymorphismsschizophreniaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 2451-2458 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	adenosine A2A receptor gene polymorphisms schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	adenosine A2A receptor gene polymorphisms schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Miao J Liu L Yan C Zhu X Fan M Yu P Ji K Huang Y Wang Y Zhu G Association between ADORA2A gene polymorphisms and schizophrenia in the North Chinese Han population
description	Junxiao Miao,1,* Lu Liu,1,2,* Ci Yan,1 Xiaotong Zhu,1 Mengqi Fan,1 Peitong Yu,1 Keming Ji,1 Yinglin Huang,3 Yuan Wang,3 Gang Zhu11Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of China; 2Department of Psychiatry, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, People’s Republic of China; 3Department of Psychiatry, Shengjing Hospital of China Medical University, Shenyang 110020, People’s Republic of ChinaCorrespondence: Gang ZhuDepartment of Psychiatry, the First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of ChinaTel/Fax +86 248 328 2184Email gzhu@cmu.edu.cn*These authors contributed equally to this workBackground: A large number of studies have shown a close relationship between ADORA2A and the pathological mechanism of schizophrenia. However, to our knowledge, there has been no studies examining the association between the ADORA2A gene and schizophrenia in Chinese Han population.Purpose: The objective of this study was to examine the relationship between adenosine A2A receptor (ADORA2A) single nucleotide polymorphisms and schizophrenia in the North Chinese Han population.Patients and methods: We detected ADORA2A single nucleotide polymorphisms (SNPs) using polymerase chain reaction-restriction fragment length polymorphism analyses and summarized our results using SPSS statistical software and Haploview in schizophrenia case group (n=398) and healthy control group (n=535).Results: The frequency of the CC homozygote genotype of SNP rs2298383T/C were significantly higher in the case than the control group (p=0.005, OR=1.712, 95% CI=1.172–2.502). After linkage disequilibrium analysis, SNPs rs5996696A/C and rs2298383T/C displayed strong linkage disequilibrium. We found that the frequencies of haplotypes TA (χ2=6.268, p=0.0123) and CA (χ2=7.012, p=0.0081) were significantly higher in the case group than in the control group.Conclusion: In conclusion, SNPs in the ADORA2A gene may be associated with schizophrenia in the northern Chinese Han population.Keywords: ADORA2A, gene polymorphisms, schizophrenia
format	article
author	Miao J Liu L Yan C Zhu X Fan M Yu P Ji K Huang Y Wang Y Zhu G
author_facet	Miao J Liu L Yan C Zhu X Fan M Yu P Ji K Huang Y Wang Y Zhu G
author_sort	Miao J
title	Association between ADORA2A gene polymorphisms and schizophrenia in the North Chinese Han population
title_short	Association between ADORA2A gene polymorphisms and schizophrenia in the North Chinese Han population
title_full	Association between ADORA2A gene polymorphisms and schizophrenia in the North Chinese Han population
title_fullStr	Association between ADORA2A gene polymorphisms and schizophrenia in the North Chinese Han population
title_full_unstemmed	Association between ADORA2A gene polymorphisms and schizophrenia in the North Chinese Han population
title_sort	association between adora2a gene polymorphisms and schizophrenia in the north chinese han population
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/bb31a15c4c0142799ab4efd49b684d57
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Association between ADORA2A gene polymorphisms and schizophrenia in the North Chinese Han population

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