A Treasure of Bioactive Compounds from the Deep Sea

The deep-sea environment is a unique, challenging extreme habitat where species have had to adapt to the absence of light, low levels of oxygen, high pressure and little food. In order to survive such harsh conditions, these organisms have evolved different biochemical and physiological features tha...

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Autores principales:	Assunta Saide, Chiara Lauritano, Adrianna Ianora
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	marine organisms bioactivities human health drug discovery marine biotechnology Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/bb32c2ef3aa343fba12656c03420d08b
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spelling	oai:doaj.org-article:bb32c2ef3aa343fba12656c03420d08b2021-11-25T16:48:59ZA Treasure of Bioactive Compounds from the Deep Sea10.3390/biomedicines91115562227-9059https://doaj.org/article/bb32c2ef3aa343fba12656c03420d08b2021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1556https://doaj.org/toc/2227-9059The deep-sea environment is a unique, challenging extreme habitat where species have had to adapt to the absence of light, low levels of oxygen, high pressure and little food. In order to survive such harsh conditions, these organisms have evolved different biochemical and physiological features that often have no other equivalent in terrestrial habitats. Recent analyses have highlighted how the deep sea is one of the most diverse and species-rich habitats on the planet but less explored compared to more accessible sites. Because of their adaptation to this extreme environment, deep-sea species have the potential to produce novel secondary metabolites with potent biological activities. Recent advances in sampling and novel techniques in microorganism culturing and chemical isolation have promoted the discovery of bioactive agents from deep-sea organisms. However, reports of natural products derived from deep-sea species are still scarce, probably because of the difficulty in accessing deep-sea samples, sampling costs and the difficulty in culturing deep-sea organisms. In this review, we give an overview of the potential treasure represented by metabolites produced by deep marine species and their bioactivities for the treatment and prevention of various human pathologies.Assunta SaideChiara LauritanoAdrianna IanoraMDPI AGarticlemarine organismsbioactivitieshuman healthdrug discoverymarine biotechnologyBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1556, p 1556 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	marine organisms bioactivities human health drug discovery marine biotechnology Biology (General) QH301-705.5
spellingShingle	marine organisms bioactivities human health drug discovery marine biotechnology Biology (General) QH301-705.5 Assunta Saide Chiara Lauritano Adrianna Ianora A Treasure of Bioactive Compounds from the Deep Sea
description	The deep-sea environment is a unique, challenging extreme habitat where species have had to adapt to the absence of light, low levels of oxygen, high pressure and little food. In order to survive such harsh conditions, these organisms have evolved different biochemical and physiological features that often have no other equivalent in terrestrial habitats. Recent analyses have highlighted how the deep sea is one of the most diverse and species-rich habitats on the planet but less explored compared to more accessible sites. Because of their adaptation to this extreme environment, deep-sea species have the potential to produce novel secondary metabolites with potent biological activities. Recent advances in sampling and novel techniques in microorganism culturing and chemical isolation have promoted the discovery of bioactive agents from deep-sea organisms. However, reports of natural products derived from deep-sea species are still scarce, probably because of the difficulty in accessing deep-sea samples, sampling costs and the difficulty in culturing deep-sea organisms. In this review, we give an overview of the potential treasure represented by metabolites produced by deep marine species and their bioactivities for the treatment and prevention of various human pathologies.
format	article
author	Assunta Saide Chiara Lauritano Adrianna Ianora
author_facet	Assunta Saide Chiara Lauritano Adrianna Ianora
author_sort	Assunta Saide
title	A Treasure of Bioactive Compounds from the Deep Sea
title_short	A Treasure of Bioactive Compounds from the Deep Sea
title_full	A Treasure of Bioactive Compounds from the Deep Sea
title_fullStr	A Treasure of Bioactive Compounds from the Deep Sea
title_full_unstemmed	A Treasure of Bioactive Compounds from the Deep Sea
title_sort	treasure of bioactive compounds from the deep sea
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bb32c2ef3aa343fba12656c03420d08b
work_keys_str_mv	AT assuntasaide atreasureofbioactivecompoundsfromthedeepsea AT chiaralauritano atreasureofbioactivecompoundsfromthedeepsea AT adriannaianora atreasureofbioactivecompoundsfromthedeepsea AT assuntasaide treasureofbioactivecompoundsfromthedeepsea AT chiaralauritano treasureofbioactivecompoundsfromthedeepsea AT adriannaianora treasureofbioactivecompoundsfromthedeepsea
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A Treasure of Bioactive Compounds from the Deep Sea

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