Impact of Compression Force on Mechanical, Textural, Release and Chewing Perception Properties of Compressible Medicated Chewing Gums

Medicated chewing gums (MCGs) represent a beneficial platform for realizing drugs intended for dental prophylaxis and treatment. The present study aimed to investigate the impact of compression force on the mechanical, textural, release, and chewing perception characteristics of compressible MCGs wi...

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Autores principales:	Yuliia Maslii, Tetiana Kolisnyk, Olena Ruban, Olga Yevtifieieva, Svitlana Gureyeva, Andriy Goy, Giedre Kasparaviciene, Zenona Kalveniene, Jurga Bernatoniene
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	compressible medicated chewing gums compression force mechanical resistance textural analysis release profile chewing perception properties Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/bb3345109e534c778e0e93ff3272f3d2
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spelling	oai:doaj.org-article:bb3345109e534c778e0e93ff3272f3d22021-11-25T18:40:50ZImpact of Compression Force on Mechanical, Textural, Release and Chewing Perception Properties of Compressible Medicated Chewing Gums10.3390/pharmaceutics131118081999-4923https://doaj.org/article/bb3345109e534c778e0e93ff3272f3d22021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1808https://doaj.org/toc/1999-4923Medicated chewing gums (MCGs) represent a beneficial platform for realizing drugs intended for dental prophylaxis and treatment. The present study aimed to investigate the impact of compression force on the mechanical, textural, release, and chewing perception characteristics of compressible MCGs with the combination of lysozyme hydrochloride (LH) and ascorbic acid (AsA). Four batches of MCGs were obtained on a laboratory single-punch tablet machine applying different forces, i.e., 5, 7, 10, and 15 kN, and evaluated by their geometrical parameters, mechanical resistance, surface and internal structure characteristics, texture profile, release behavior, and perception attributes during mastication. It was found that increasing compression force slightly affected resistance to crushing and friability of MCGs, but resulted in surface smoothing and formation of a thicker layer with highly compacted particle arrangement. According to the texture analysis, increasing compression force led to harder and more adhesive gums, indicating possible difficulties in chewing and, therefore, impairment of their consumer properties. Lower compression forces were also found to be preferable in terms of better drug release from the obtained chewing gums. The volunteers’ assessment showed that an increase of compression force led to significantly raising the initial hardness and crumbliness as well as to decreasing the rate of the integral gum mass formation during mastication, which may negatively affect perceptive sensations when using MCGs. Based on the results obtained, the optimal compressing force was selected to be 7 kN, which allows obtaining MCGs with good organoleptic, mechanical, textural, and release properties.Yuliia MasliiTetiana KolisnykOlena RubanOlga YevtifieievaSvitlana GureyevaAndriy GoyGiedre KasparavicieneZenona KalvenieneJurga BernatonieneMDPI AGarticlecompressible medicated chewing gumscompression forcemechanical resistancetextural analysisrelease profilechewing perception propertiesPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1808, p 1808 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	compressible medicated chewing gums compression force mechanical resistance textural analysis release profile chewing perception properties Pharmacy and materia medica RS1-441
spellingShingle	compressible medicated chewing gums compression force mechanical resistance textural analysis release profile chewing perception properties Pharmacy and materia medica RS1-441 Yuliia Maslii Tetiana Kolisnyk Olena Ruban Olga Yevtifieieva Svitlana Gureyeva Andriy Goy Giedre Kasparaviciene Zenona Kalveniene Jurga Bernatoniene Impact of Compression Force on Mechanical, Textural, Release and Chewing Perception Properties of Compressible Medicated Chewing Gums
description	Medicated chewing gums (MCGs) represent a beneficial platform for realizing drugs intended for dental prophylaxis and treatment. The present study aimed to investigate the impact of compression force on the mechanical, textural, release, and chewing perception characteristics of compressible MCGs with the combination of lysozyme hydrochloride (LH) and ascorbic acid (AsA). Four batches of MCGs were obtained on a laboratory single-punch tablet machine applying different forces, i.e., 5, 7, 10, and 15 kN, and evaluated by their geometrical parameters, mechanical resistance, surface and internal structure characteristics, texture profile, release behavior, and perception attributes during mastication. It was found that increasing compression force slightly affected resistance to crushing and friability of MCGs, but resulted in surface smoothing and formation of a thicker layer with highly compacted particle arrangement. According to the texture analysis, increasing compression force led to harder and more adhesive gums, indicating possible difficulties in chewing and, therefore, impairment of their consumer properties. Lower compression forces were also found to be preferable in terms of better drug release from the obtained chewing gums. The volunteers’ assessment showed that an increase of compression force led to significantly raising the initial hardness and crumbliness as well as to decreasing the rate of the integral gum mass formation during mastication, which may negatively affect perceptive sensations when using MCGs. Based on the results obtained, the optimal compressing force was selected to be 7 kN, which allows obtaining MCGs with good organoleptic, mechanical, textural, and release properties.
format	article
author	Yuliia Maslii Tetiana Kolisnyk Olena Ruban Olga Yevtifieieva Svitlana Gureyeva Andriy Goy Giedre Kasparaviciene Zenona Kalveniene Jurga Bernatoniene
author_facet	Yuliia Maslii Tetiana Kolisnyk Olena Ruban Olga Yevtifieieva Svitlana Gureyeva Andriy Goy Giedre Kasparaviciene Zenona Kalveniene Jurga Bernatoniene
author_sort	Yuliia Maslii
title	Impact of Compression Force on Mechanical, Textural, Release and Chewing Perception Properties of Compressible Medicated Chewing Gums
title_short	Impact of Compression Force on Mechanical, Textural, Release and Chewing Perception Properties of Compressible Medicated Chewing Gums
title_full	Impact of Compression Force on Mechanical, Textural, Release and Chewing Perception Properties of Compressible Medicated Chewing Gums
title_fullStr	Impact of Compression Force on Mechanical, Textural, Release and Chewing Perception Properties of Compressible Medicated Chewing Gums
title_full_unstemmed	Impact of Compression Force on Mechanical, Textural, Release and Chewing Perception Properties of Compressible Medicated Chewing Gums
title_sort	impact of compression force on mechanical, textural, release and chewing perception properties of compressible medicated chewing gums
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bb3345109e534c778e0e93ff3272f3d2
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Impact of Compression Force on Mechanical, Textural, Release and Chewing Perception Properties of Compressible Medicated Chewing Gums

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