Increased Stability and Breakdown of Brain Effective Connectivity During Slow-Wave Sleep: Mechanistic Insights from Whole-Brain Computational Modelling

Abstract Recent research has found that the human sleep cycle is characterised by changes in spatiotemporal patterns of brain activity. Yet, we are still missing a mechanistic explanation of the local neuronal dynamics underlying these changes. We used whole-brain computational modelling to study th...

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Autores principales:	Beatrice M. Jobst, Rikkert Hindriks, Helmut Laufs, Enzo Tagliazucchi, Gerald Hahn, Adrián Ponce-Alvarez, Angus B. A. Stevner, Morten L. Kringelbach, Gustavo Deco
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bb347e7be4c34247afc79a563803bf1a
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spelling	oai:doaj.org-article:bb347e7be4c34247afc79a563803bf1a2021-12-02T12:32:02ZIncreased Stability and Breakdown of Brain Effective Connectivity During Slow-Wave Sleep: Mechanistic Insights from Whole-Brain Computational Modelling10.1038/s41598-017-04522-x2045-2322https://doaj.org/article/bb347e7be4c34247afc79a563803bf1a2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04522-xhttps://doaj.org/toc/2045-2322Abstract Recent research has found that the human sleep cycle is characterised by changes in spatiotemporal patterns of brain activity. Yet, we are still missing a mechanistic explanation of the local neuronal dynamics underlying these changes. We used whole-brain computational modelling to study the differences in global brain functional connectivity and synchrony of fMRI activity in healthy humans during wakefulness and slow-wave sleep. We applied a whole-brain model based on the normal form of a supercritical Hopf bifurcation and studied the dynamical changes when adapting the bifurcation parameter for all brain nodes to best match wakefulness and slow-wave sleep. Furthermore, we analysed differences in effective connectivity between the two states. In addition to significant changes in functional connectivity, synchrony and metastability, this analysis revealed a significant shift of the global dynamic working point of brain dynamics, from the edge of the transition between damped to sustained oscillations during wakefulness, to a stable focus during slow-wave sleep. Moreover, we identified a significant global decrease in effective interactions during slow-wave sleep. These results suggest a mechanism for the empirical functional changes observed during slow-wave sleep, namely a global shift of the brain’s dynamic working point leading to increased stability and decreased effective connectivity.Beatrice M. JobstRikkert HindriksHelmut LaufsEnzo TagliazucchiGerald HahnAdrián Ponce-AlvarezAngus B. A. StevnerMorten L. KringelbachGustavo DecoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Beatrice M. Jobst Rikkert Hindriks Helmut Laufs Enzo Tagliazucchi Gerald Hahn Adrián Ponce-Alvarez Angus B. A. Stevner Morten L. Kringelbach Gustavo Deco Increased Stability and Breakdown of Brain Effective Connectivity During Slow-Wave Sleep: Mechanistic Insights from Whole-Brain Computational Modelling
description	Abstract Recent research has found that the human sleep cycle is characterised by changes in spatiotemporal patterns of brain activity. Yet, we are still missing a mechanistic explanation of the local neuronal dynamics underlying these changes. We used whole-brain computational modelling to study the differences in global brain functional connectivity and synchrony of fMRI activity in healthy humans during wakefulness and slow-wave sleep. We applied a whole-brain model based on the normal form of a supercritical Hopf bifurcation and studied the dynamical changes when adapting the bifurcation parameter for all brain nodes to best match wakefulness and slow-wave sleep. Furthermore, we analysed differences in effective connectivity between the two states. In addition to significant changes in functional connectivity, synchrony and metastability, this analysis revealed a significant shift of the global dynamic working point of brain dynamics, from the edge of the transition between damped to sustained oscillations during wakefulness, to a stable focus during slow-wave sleep. Moreover, we identified a significant global decrease in effective interactions during slow-wave sleep. These results suggest a mechanism for the empirical functional changes observed during slow-wave sleep, namely a global shift of the brain’s dynamic working point leading to increased stability and decreased effective connectivity.
format	article
author	Beatrice M. Jobst Rikkert Hindriks Helmut Laufs Enzo Tagliazucchi Gerald Hahn Adrián Ponce-Alvarez Angus B. A. Stevner Morten L. Kringelbach Gustavo Deco
author_facet	Beatrice M. Jobst Rikkert Hindriks Helmut Laufs Enzo Tagliazucchi Gerald Hahn Adrián Ponce-Alvarez Angus B. A. Stevner Morten L. Kringelbach Gustavo Deco
author_sort	Beatrice M. Jobst
title	Increased Stability and Breakdown of Brain Effective Connectivity During Slow-Wave Sleep: Mechanistic Insights from Whole-Brain Computational Modelling
title_short	Increased Stability and Breakdown of Brain Effective Connectivity During Slow-Wave Sleep: Mechanistic Insights from Whole-Brain Computational Modelling
title_full	Increased Stability and Breakdown of Brain Effective Connectivity During Slow-Wave Sleep: Mechanistic Insights from Whole-Brain Computational Modelling
title_fullStr	Increased Stability and Breakdown of Brain Effective Connectivity During Slow-Wave Sleep: Mechanistic Insights from Whole-Brain Computational Modelling
title_full_unstemmed	Increased Stability and Breakdown of Brain Effective Connectivity During Slow-Wave Sleep: Mechanistic Insights from Whole-Brain Computational Modelling
title_sort	increased stability and breakdown of brain effective connectivity during slow-wave sleep: mechanistic insights from whole-brain computational modelling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bb347e7be4c34247afc79a563803bf1a
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Increased Stability and Breakdown of Brain Effective Connectivity During Slow-Wave Sleep: Mechanistic Insights from Whole-Brain Computational Modelling

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