The Retinal Posterior Pole in Early Parkinson’s Disease: A Fundus Perimetry and SD-OCT Study
Massimo Cesareo,1 Ernesto Di Marco,1 Clarissa Giannini,1 Matteo Di Marino,1 Francesco Aiello,1 Antonio Pisani,2 Mariangela Pierantozzi,3 Nicola Biagio Mercuri,4,5 Carlo Nucci,1 Raffaele Mancino1 1Ophthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy; 2D...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/bb35fbc206dd46a5a00f3ef05d17b562 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:bb35fbc206dd46a5a00f3ef05d17b562 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:bb35fbc206dd46a5a00f3ef05d17b5622021-12-02T17:41:41ZThe Retinal Posterior Pole in Early Parkinson’s Disease: A Fundus Perimetry and SD-OCT Study1177-5483https://doaj.org/article/bb35fbc206dd46a5a00f3ef05d17b5622021-10-01T00:00:00Zhttps://www.dovepress.com/the-retinal-posterior-pole-in-early-parkinsons-disease-a-fundus-perime-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Massimo Cesareo,1 Ernesto Di Marco,1 Clarissa Giannini,1 Matteo Di Marino,1 Francesco Aiello,1 Antonio Pisani,2 Mariangela Pierantozzi,3 Nicola Biagio Mercuri,4,5 Carlo Nucci,1 Raffaele Mancino1 1Ophthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy; 2Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; 3Parkinson’s Center, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; 4Neurology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; 5Fondazione Santa Lucia I.R.C.C.S, Rome, ItalyCorrespondence: Massimo Cesareo; Ernesto Di MarcoOphthalmology Unit, Department of Experimental Medicine University of Rome “Tor Vergata”, via Montpellier, Rome, 100133, ItalyTel/Fax +39 0620902973Email massimo.cesareo@uniroma2.it; Ernesto2601@hotmail.itPurpose: To assess the structure and function of the retinal posterior pole in patients with early Parkinson’s disease (PD) and to identify possible biomarkers correlated with clinical features.Patients and Methods: A cross-sectional case-control study of 21 patients with PD and 22 age-matched healthy controls (HC) was conducted. All subjects underwent full ophthalmological examinations, fundus perimetry (FP) and spectral domain-OCT (SD-OCT) of the entire retinal posterior pole and peripapillary retinal nerve fiber layer (pRNFL).Results: We analyzed 41 eyes from 21 patients (14 males and 7 females) with early PD (Hoehn and Yahr scale (H&Y) equal to or less than stage 2) and 41 eyes from 22 HC (12 males and 10 females). We found no significant difference in the pRNFL thickness between patients with PD and HC. The statistical analysis of the SD-OCT posterior pole area, consisting of 64 values for each retinal layer, revealed a decrease in the outer nuclear layer (ONL) thickness in patients with PD (p < 0.0001). On the contrary, a significant increase in the thickness of the outer plexiform layer (OPL) (p < 0.0001) and of the retinal pigmented epithelium (RPE) (p= 0.002) compared to healthy controls was detected. Other retinal layers showed no significant statistical differences. The differential light sensitivity (DLS) values measured by FP were significantly lower in patients than the healthy controls (15 [13– 16.2] vs 17.95 [16.08– 18.96] p< 0.0001).Conclusion: Our results showed that DLS and retinal structure differed in the posterior pole between patients with early PD and controls. Thickening of the OPL may represent accumulation of α-synuclein in the OPL of patients with PD.Keywords: Parkinson’s disease, optical coherence tomography, retina, dopamine, alpha-synucleinCesareo MDi Marco EGiannini CDi Marino MAiello FPisani APierantozzi MMercuri NBNucci CMancino RDove Medical Pressarticleparkinson's diseaseoptical coherence tomographyretinadopaminealpha-synucleinOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 4005-4014 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
parkinson's disease optical coherence tomography retina dopamine alpha-synuclein Ophthalmology RE1-994 |
| spellingShingle |
parkinson's disease optical coherence tomography retina dopamine alpha-synuclein Ophthalmology RE1-994 Cesareo M Di Marco E Giannini C Di Marino M Aiello F Pisani A Pierantozzi M Mercuri NB Nucci C Mancino R The Retinal Posterior Pole in Early Parkinson’s Disease: A Fundus Perimetry and SD-OCT Study |
| description |
Massimo Cesareo,1 Ernesto Di Marco,1 Clarissa Giannini,1 Matteo Di Marino,1 Francesco Aiello,1 Antonio Pisani,2 Mariangela Pierantozzi,3 Nicola Biagio Mercuri,4,5 Carlo Nucci,1 Raffaele Mancino1 1Ophthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy; 2Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; 3Parkinson’s Center, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; 4Neurology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; 5Fondazione Santa Lucia I.R.C.C.S, Rome, ItalyCorrespondence: Massimo Cesareo; Ernesto Di MarcoOphthalmology Unit, Department of Experimental Medicine University of Rome “Tor Vergata”, via Montpellier, Rome, 100133, ItalyTel/Fax +39 0620902973Email massimo.cesareo@uniroma2.it; Ernesto2601@hotmail.itPurpose: To assess the structure and function of the retinal posterior pole in patients with early Parkinson’s disease (PD) and to identify possible biomarkers correlated with clinical features.Patients and Methods: A cross-sectional case-control study of 21 patients with PD and 22 age-matched healthy controls (HC) was conducted. All subjects underwent full ophthalmological examinations, fundus perimetry (FP) and spectral domain-OCT (SD-OCT) of the entire retinal posterior pole and peripapillary retinal nerve fiber layer (pRNFL).Results: We analyzed 41 eyes from 21 patients (14 males and 7 females) with early PD (Hoehn and Yahr scale (H&Y) equal to or less than stage 2) and 41 eyes from 22 HC (12 males and 10 females). We found no significant difference in the pRNFL thickness between patients with PD and HC. The statistical analysis of the SD-OCT posterior pole area, consisting of 64 values for each retinal layer, revealed a decrease in the outer nuclear layer (ONL) thickness in patients with PD (p < 0.0001). On the contrary, a significant increase in the thickness of the outer plexiform layer (OPL) (p < 0.0001) and of the retinal pigmented epithelium (RPE) (p= 0.002) compared to healthy controls was detected. Other retinal layers showed no significant statistical differences. The differential light sensitivity (DLS) values measured by FP were significantly lower in patients than the healthy controls (15 [13– 16.2] vs 17.95 [16.08– 18.96] p< 0.0001).Conclusion: Our results showed that DLS and retinal structure differed in the posterior pole between patients with early PD and controls. Thickening of the OPL may represent accumulation of α-synuclein in the OPL of patients with PD.Keywords: Parkinson’s disease, optical coherence tomography, retina, dopamine, alpha-synuclein |
| format |
article |
| author |
Cesareo M Di Marco E Giannini C Di Marino M Aiello F Pisani A Pierantozzi M Mercuri NB Nucci C Mancino R |
| author_facet |
Cesareo M Di Marco E Giannini C Di Marino M Aiello F Pisani A Pierantozzi M Mercuri NB Nucci C Mancino R |
| author_sort |
Cesareo M |
| title |
The Retinal Posterior Pole in Early Parkinson’s Disease: A Fundus Perimetry and SD-OCT Study |
| title_short |
The Retinal Posterior Pole in Early Parkinson’s Disease: A Fundus Perimetry and SD-OCT Study |
| title_full |
The Retinal Posterior Pole in Early Parkinson’s Disease: A Fundus Perimetry and SD-OCT Study |
| title_fullStr |
The Retinal Posterior Pole in Early Parkinson’s Disease: A Fundus Perimetry and SD-OCT Study |
| title_full_unstemmed |
The Retinal Posterior Pole in Early Parkinson’s Disease: A Fundus Perimetry and SD-OCT Study |
| title_sort |
retinal posterior pole in early parkinson’s disease: a fundus perimetry and sd-oct study |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/bb35fbc206dd46a5a00f3ef05d17b562 |
| work_keys_str_mv |
AT cesareom theretinalposteriorpoleinearlyparkinsonrsquosdiseaseafundusperimetryandsdoctstudy AT dimarcoe theretinalposteriorpoleinearlyparkinsonrsquosdiseaseafundusperimetryandsdoctstudy AT gianninic theretinalposteriorpoleinearlyparkinsonrsquosdiseaseafundusperimetryandsdoctstudy AT dimarinom theretinalposteriorpoleinearlyparkinsonrsquosdiseaseafundusperimetryandsdoctstudy AT aiellof theretinalposteriorpoleinearlyparkinsonrsquosdiseaseafundusperimetryandsdoctstudy AT pisania theretinalposteriorpoleinearlyparkinsonrsquosdiseaseafundusperimetryandsdoctstudy AT pierantozzim theretinalposteriorpoleinearlyparkinsonrsquosdiseaseafundusperimetryandsdoctstudy AT mercurinb theretinalposteriorpoleinearlyparkinsonrsquosdiseaseafundusperimetryandsdoctstudy AT nuccic theretinalposteriorpoleinearlyparkinsonrsquosdiseaseafundusperimetryandsdoctstudy AT mancinor theretinalposteriorpoleinearlyparkinsonrsquosdiseaseafundusperimetryandsdoctstudy AT cesareom retinalposteriorpoleinearlyparkinsonrsquosdiseaseafundusperimetryandsdoctstudy AT dimarcoe retinalposteriorpoleinearlyparkinsonrsquosdiseaseafundusperimetryandsdoctstudy AT gianninic retinalposteriorpoleinearlyparkinsonrsquosdiseaseafundusperimetryandsdoctstudy AT dimarinom retinalposteriorpoleinearlyparkinsonrsquosdiseaseafundusperimetryandsdoctstudy AT aiellof retinalposteriorpoleinearlyparkinsonrsquosdiseaseafundusperimetryandsdoctstudy AT pisania retinalposteriorpoleinearlyparkinsonrsquosdiseaseafundusperimetryandsdoctstudy AT pierantozzim retinalposteriorpoleinearlyparkinsonrsquosdiseaseafundusperimetryandsdoctstudy AT mercurinb retinalposteriorpoleinearlyparkinsonrsquosdiseaseafundusperimetryandsdoctstudy AT nuccic retinalposteriorpoleinearlyparkinsonrsquosdiseaseafundusperimetryandsdoctstudy AT mancinor retinalposteriorpoleinearlyparkinsonrsquosdiseaseafundusperimetryandsdoctstudy |
| _version_ |
1718379665354129408 |