Baseline characteristics of myopic choroidal neovascularization in patients above 50 years old and prognostic factors after intravitreal conbercept treatment

Abstract To investigate the influence of age on the function and morphology of patients with myopic choroidal neovascularization (mCNV) and to evaluate the effect and prognostic factors of recurrence of Conbercept treatment on mCNV patients over 50 years. A total of 64 patients (64 eyes) with mCNV w...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hai-Yan Wang, Meng-Zhang Tao, Xi-Xi Wang, Man-Hong Li, Zi-Feng Zhang, Dong-Jie Sun, Jin-Ting Zhu, Yu-Sheng Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bb377199fded495287fa8b21c0d62032
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bb377199fded495287fa8b21c0d62032
record_format	dspace
spelling	oai:doaj.org-article:bb377199fded495287fa8b21c0d620322021-12-02T13:26:50ZBaseline characteristics of myopic choroidal neovascularization in patients above 50 years old and prognostic factors after intravitreal conbercept treatment10.1038/s41598-021-86835-62045-2322https://doaj.org/article/bb377199fded495287fa8b21c0d620322021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86835-6https://doaj.org/toc/2045-2322Abstract To investigate the influence of age on the function and morphology of patients with myopic choroidal neovascularization (mCNV) and to evaluate the effect and prognostic factors of recurrence of Conbercept treatment on mCNV patients over 50 years. A total of 64 patients (64 eyes) with mCNV were enrolled in this retrospective study. The differences in baseline best-corrected visual acuity (BCVA) and morphological features on imaging between the younger group (˂ 50 years) and the older group (≥ 50 years) were analyzed. Of all, 21 eyes of 21 mCNV patients aged over 50 years who received Conbercept injection were further analyzed. Between the younger and the older group, significant differences were shown in mean BCVA (0.58 ± 0.28 vs 0.77 ± 0.31), subfoveal choroidal thickness (SFCT) (108.17 ± 78.32 μm vs 54.68 ± 39.03 μm) and frequency of vitreoretinal interface abnormalities (VIA) (2 vs 13), respectively (P < 0.05). After treated with Conbercept, the mean BCVA of 21 older mCNV patients increased from 0.83 ± 0.30 at baseline to 0.49 ± 0.24 at one year. Baseline BCVA, external limiting membrane damage, CNV area and CNV location correlated with the visual acuity at the 1-year follow-up. There were 7 (33.3%) recurrent cases during the follow-up and the risk of recurrence in patients with baseline central macular thickness (CMT) ≥ 262.86 μm was 14 times greater than that of patients with CMT < 262.86 μm. The risk of recurrence increased 1.84 times for every 100-μm increment in the CMT. Patients over 50 years with mCNV had a worse BCVA, thinner choroid, and higher risk of VIA than young mCNV patients. The standard Conbercept treatment strategy was safe and effective in mCNV patients over 50 years. As patients over 50 years with a greater CMT have a high risk of recurrence, more attention should be paid on these patients by following them up closely.Hai-Yan WangMeng-Zhang TaoXi-Xi WangMan-Hong LiZi-Feng ZhangDong-Jie SunJin-Ting ZhuYu-Sheng WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hai-Yan Wang Meng-Zhang Tao Xi-Xi Wang Man-Hong Li Zi-Feng Zhang Dong-Jie Sun Jin-Ting Zhu Yu-Sheng Wang Baseline characteristics of myopic choroidal neovascularization in patients above 50 years old and prognostic factors after intravitreal conbercept treatment
description	Abstract To investigate the influence of age on the function and morphology of patients with myopic choroidal neovascularization (mCNV) and to evaluate the effect and prognostic factors of recurrence of Conbercept treatment on mCNV patients over 50 years. A total of 64 patients (64 eyes) with mCNV were enrolled in this retrospective study. The differences in baseline best-corrected visual acuity (BCVA) and morphological features on imaging between the younger group (˂ 50 years) and the older group (≥ 50 years) were analyzed. Of all, 21 eyes of 21 mCNV patients aged over 50 years who received Conbercept injection were further analyzed. Between the younger and the older group, significant differences were shown in mean BCVA (0.58 ± 0.28 vs 0.77 ± 0.31), subfoveal choroidal thickness (SFCT) (108.17 ± 78.32 μm vs 54.68 ± 39.03 μm) and frequency of vitreoretinal interface abnormalities (VIA) (2 vs 13), respectively (P < 0.05). After treated with Conbercept, the mean BCVA of 21 older mCNV patients increased from 0.83 ± 0.30 at baseline to 0.49 ± 0.24 at one year. Baseline BCVA, external limiting membrane damage, CNV area and CNV location correlated with the visual acuity at the 1-year follow-up. There were 7 (33.3%) recurrent cases during the follow-up and the risk of recurrence in patients with baseline central macular thickness (CMT) ≥ 262.86 μm was 14 times greater than that of patients with CMT < 262.86 μm. The risk of recurrence increased 1.84 times for every 100-μm increment in the CMT. Patients over 50 years with mCNV had a worse BCVA, thinner choroid, and higher risk of VIA than young mCNV patients. The standard Conbercept treatment strategy was safe and effective in mCNV patients over 50 years. As patients over 50 years with a greater CMT have a high risk of recurrence, more attention should be paid on these patients by following them up closely.
format	article
author	Hai-Yan Wang Meng-Zhang Tao Xi-Xi Wang Man-Hong Li Zi-Feng Zhang Dong-Jie Sun Jin-Ting Zhu Yu-Sheng Wang
author_facet	Hai-Yan Wang Meng-Zhang Tao Xi-Xi Wang Man-Hong Li Zi-Feng Zhang Dong-Jie Sun Jin-Ting Zhu Yu-Sheng Wang
author_sort	Hai-Yan Wang
title	Baseline characteristics of myopic choroidal neovascularization in patients above 50 years old and prognostic factors after intravitreal conbercept treatment
title_short	Baseline characteristics of myopic choroidal neovascularization in patients above 50 years old and prognostic factors after intravitreal conbercept treatment
title_full	Baseline characteristics of myopic choroidal neovascularization in patients above 50 years old and prognostic factors after intravitreal conbercept treatment
title_fullStr	Baseline characteristics of myopic choroidal neovascularization in patients above 50 years old and prognostic factors after intravitreal conbercept treatment
title_full_unstemmed	Baseline characteristics of myopic choroidal neovascularization in patients above 50 years old and prognostic factors after intravitreal conbercept treatment
title_sort	baseline characteristics of myopic choroidal neovascularization in patients above 50 years old and prognostic factors after intravitreal conbercept treatment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bb377199fded495287fa8b21c0d62032
work_keys_str_mv	AT haiyanwang baselinecharacteristicsofmyopicchoroidalneovascularizationinpatientsabove50yearsoldandprognosticfactorsafterintravitrealconbercepttreatment AT mengzhangtao baselinecharacteristicsofmyopicchoroidalneovascularizationinpatientsabove50yearsoldandprognosticfactorsafterintravitrealconbercepttreatment AT xixiwang baselinecharacteristicsofmyopicchoroidalneovascularizationinpatientsabove50yearsoldandprognosticfactorsafterintravitrealconbercepttreatment AT manhongli baselinecharacteristicsofmyopicchoroidalneovascularizationinpatientsabove50yearsoldandprognosticfactorsafterintravitrealconbercepttreatment AT zifengzhang baselinecharacteristicsofmyopicchoroidalneovascularizationinpatientsabove50yearsoldandprognosticfactorsafterintravitrealconbercepttreatment AT dongjiesun baselinecharacteristicsofmyopicchoroidalneovascularizationinpatientsabove50yearsoldandprognosticfactorsafterintravitrealconbercepttreatment AT jintingzhu baselinecharacteristicsofmyopicchoroidalneovascularizationinpatientsabove50yearsoldandprognosticfactorsafterintravitrealconbercepttreatment AT yushengwang baselinecharacteristicsofmyopicchoroidalneovascularizationinpatientsabove50yearsoldandprognosticfactorsafterintravitrealconbercepttreatment
_version_	1718393055555354624

Baseline characteristics of myopic choroidal neovascularization in patients above 50 years old and prognostic factors after intravitreal conbercept treatment

Ejemplares similares