The neuritic plaque facilitates pathological conversion of tau in an Alzheimer’s disease mouse model

Alzheimer’s disease (AD) is pathologically characterized by the accumulation of neuritic plaques and neurofibrillary tangles but it is not known whether the neuritic plaque is necessary to drive the conversion of wild-type tau. Here the authors developed a mouse model in which wild-type tau is conve...

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Autores principales:	Tong Li, Kerstin E. Braunstein, Juhong Zhang, Ashley Lau, Leslie Sibener, Christopher Deeble, Philip C. Wong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bb3ab0a6abe54a1e8baf5507b43d6207
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spelling	oai:doaj.org-article:bb3ab0a6abe54a1e8baf5507b43d62072021-12-02T16:50:15ZThe neuritic plaque facilitates pathological conversion of tau in an Alzheimer’s disease mouse model10.1038/ncomms120822041-1723https://doaj.org/article/bb3ab0a6abe54a1e8baf5507b43d62072016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12082https://doaj.org/toc/2041-1723Alzheimer’s disease (AD) is pathologically characterized by the accumulation of neuritic plaques and neurofibrillary tangles but it is not known whether the neuritic plaque is necessary to drive the conversion of wild-type tau. Here the authors developed a mouse model in which wild-type tau is converted into pathological tau in a neuritic plaque-dependent manner.Tong LiKerstin E. BraunsteinJuhong ZhangAshley LauLeslie SibenerChristopher DeeblePhilip C. WongNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tong Li Kerstin E. Braunstein Juhong Zhang Ashley Lau Leslie Sibener Christopher Deeble Philip C. Wong The neuritic plaque facilitates pathological conversion of tau in an Alzheimer’s disease mouse model
description	Alzheimer’s disease (AD) is pathologically characterized by the accumulation of neuritic plaques and neurofibrillary tangles but it is not known whether the neuritic plaque is necessary to drive the conversion of wild-type tau. Here the authors developed a mouse model in which wild-type tau is converted into pathological tau in a neuritic plaque-dependent manner.
format	article
author	Tong Li Kerstin E. Braunstein Juhong Zhang Ashley Lau Leslie Sibener Christopher Deeble Philip C. Wong
author_facet	Tong Li Kerstin E. Braunstein Juhong Zhang Ashley Lau Leslie Sibener Christopher Deeble Philip C. Wong
author_sort	Tong Li
title	The neuritic plaque facilitates pathological conversion of tau in an Alzheimer’s disease mouse model
title_short	The neuritic plaque facilitates pathological conversion of tau in an Alzheimer’s disease mouse model
title_full	The neuritic plaque facilitates pathological conversion of tau in an Alzheimer’s disease mouse model
title_fullStr	The neuritic plaque facilitates pathological conversion of tau in an Alzheimer’s disease mouse model
title_full_unstemmed	The neuritic plaque facilitates pathological conversion of tau in an Alzheimer’s disease mouse model
title_sort	neuritic plaque facilitates pathological conversion of tau in an alzheimer’s disease mouse model
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/bb3ab0a6abe54a1e8baf5507b43d6207
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The neuritic plaque facilitates pathological conversion of tau in an Alzheimer’s disease mouse model

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