Epigenetic Dysregulations in Merkel Cell Polyomavirus-Driven Merkel Cell Carcinoma

Merkel cell polyomavirus (MCPyV) is a small DNA virus with oncogenic potential. MCPyV is the causative agent of Merkel Cell Carcinoma (MCC), a rare but aggressive tumor of the skin. The role of epigenetic mechanisms, such as histone posttranslational modifications (HPTMs), DNA methylation, and micro...

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Autores principales:	John Charles Rotondo, Chiara Mazziotta, Carmen Lanzillotti, Mauro Tognon, Fernanda Martini
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Merkel cell polyomavirus (MCPyV) Merkel cell carcinoma (MCC) epigenetics virus-driven tumors histone posttranslational modifications HPTMs Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/bb3c7942bb674a8399bc23ce3fda37b1
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spelling	oai:doaj.org-article:bb3c7942bb674a8399bc23ce3fda37b12021-11-11T16:55:40ZEpigenetic Dysregulations in Merkel Cell Polyomavirus-Driven Merkel Cell Carcinoma10.3390/ijms2221114641422-00671661-6596https://doaj.org/article/bb3c7942bb674a8399bc23ce3fda37b12021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11464https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Merkel cell polyomavirus (MCPyV) is a small DNA virus with oncogenic potential. MCPyV is the causative agent of Merkel Cell Carcinoma (MCC), a rare but aggressive tumor of the skin. The role of epigenetic mechanisms, such as histone posttranslational modifications (HPTMs), DNA methylation, and microRNA (miRNA) regulation on MCPyV-driven MCC has recently been highlighted. In this review, we aim to describe and discuss the latest insights into HPTMs, DNA methylation, and miRNA regulation, as well as their regulative factors in the context of MCPyV-driven MCC, to provide an overview of current findings on how MCPyV is involved in the dysregulation of these epigenetic processes. The current state of the art is also described as far as potentially using epigenetic dysregulations and related factors as diagnostic and prognostic tools is concerned, in addition to targets for MCPyV-driven MCC therapy. Growing evidence suggests that the dysregulation of HPTMs, DNA methylation, and miRNA pathways plays a role in MCPyV-driven MCC etiopathogenesis, which, therefore, may potentially be clinically significant for this deadly tumor. A deeper understanding of these mechanisms and related factors may improve diagnosis, prognosis, and therapy for MCPyV-driven MCC.John Charles RotondoChiara MazziottaCarmen LanzillottiMauro TognonFernanda MartiniMDPI AGarticleMerkel cell polyomavirus (MCPyV)Merkel cell carcinoma (MCC)epigeneticsvirus-driven tumorshistone posttranslational modificationsHPTMsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11464, p 11464 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Merkel cell polyomavirus (MCPyV) Merkel cell carcinoma (MCC) epigenetics virus-driven tumors histone posttranslational modifications HPTMs Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	Merkel cell polyomavirus (MCPyV) Merkel cell carcinoma (MCC) epigenetics virus-driven tumors histone posttranslational modifications HPTMs Biology (General) QH301-705.5 Chemistry QD1-999 John Charles Rotondo Chiara Mazziotta Carmen Lanzillotti Mauro Tognon Fernanda Martini Epigenetic Dysregulations in Merkel Cell Polyomavirus-Driven Merkel Cell Carcinoma
description	Merkel cell polyomavirus (MCPyV) is a small DNA virus with oncogenic potential. MCPyV is the causative agent of Merkel Cell Carcinoma (MCC), a rare but aggressive tumor of the skin. The role of epigenetic mechanisms, such as histone posttranslational modifications (HPTMs), DNA methylation, and microRNA (miRNA) regulation on MCPyV-driven MCC has recently been highlighted. In this review, we aim to describe and discuss the latest insights into HPTMs, DNA methylation, and miRNA regulation, as well as their regulative factors in the context of MCPyV-driven MCC, to provide an overview of current findings on how MCPyV is involved in the dysregulation of these epigenetic processes. The current state of the art is also described as far as potentially using epigenetic dysregulations and related factors as diagnostic and prognostic tools is concerned, in addition to targets for MCPyV-driven MCC therapy. Growing evidence suggests that the dysregulation of HPTMs, DNA methylation, and miRNA pathways plays a role in MCPyV-driven MCC etiopathogenesis, which, therefore, may potentially be clinically significant for this deadly tumor. A deeper understanding of these mechanisms and related factors may improve diagnosis, prognosis, and therapy for MCPyV-driven MCC.
format	article
author	John Charles Rotondo Chiara Mazziotta Carmen Lanzillotti Mauro Tognon Fernanda Martini
author_facet	John Charles Rotondo Chiara Mazziotta Carmen Lanzillotti Mauro Tognon Fernanda Martini
author_sort	John Charles Rotondo
title	Epigenetic Dysregulations in Merkel Cell Polyomavirus-Driven Merkel Cell Carcinoma
title_short	Epigenetic Dysregulations in Merkel Cell Polyomavirus-Driven Merkel Cell Carcinoma
title_full	Epigenetic Dysregulations in Merkel Cell Polyomavirus-Driven Merkel Cell Carcinoma
title_fullStr	Epigenetic Dysregulations in Merkel Cell Polyomavirus-Driven Merkel Cell Carcinoma
title_full_unstemmed	Epigenetic Dysregulations in Merkel Cell Polyomavirus-Driven Merkel Cell Carcinoma
title_sort	epigenetic dysregulations in merkel cell polyomavirus-driven merkel cell carcinoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bb3c7942bb674a8399bc23ce3fda37b1
work_keys_str_mv	AT johncharlesrotondo epigeneticdysregulationsinmerkelcellpolyomavirusdrivenmerkelcellcarcinoma AT chiaramazziotta epigeneticdysregulationsinmerkelcellpolyomavirusdrivenmerkelcellcarcinoma AT carmenlanzillotti epigeneticdysregulationsinmerkelcellpolyomavirusdrivenmerkelcellcarcinoma AT maurotognon epigeneticdysregulationsinmerkelcellpolyomavirusdrivenmerkelcellcarcinoma AT fernandamartini epigeneticdysregulationsinmerkelcellpolyomavirusdrivenmerkelcellcarcinoma
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Epigenetic Dysregulations in Merkel Cell Polyomavirus-Driven Merkel Cell Carcinoma

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