АNALYSIS OF THE EXPRESSION LEVEL OF T-CELL GENES AND OXIDATIVE PROCESSES IN STROKE

The level of expression of genes of transcription factors (GATA-3, TBX21, IL-2PG), and changing of oxidative processes in ischemic stroke were studied.It was found that activation of Th2 cells (increase in the expression of transcription factor GATA-3) is observed in stroke, and suppression of Th...

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Autores principales:	H. V. Zanginyan, L. M. Hovsepyan, G. S. Kazaryan, G. V. Zakaryan
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	stroke gene expression oxidative modification of protein glutathione Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/bb3e6473a18a491fb822c39074ce8254
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spelling	oai:doaj.org-article:bb3e6473a18a491fb822c39074ce82542021-11-18T08:03:48ZАNALYSIS OF THE EXPRESSION LEVEL OF T-CELL GENES AND OXIDATIVE PROCESSES IN STROKE1563-06252313-741X10.15789/1563-0625-2019-2-251-256https://doaj.org/article/bb3e6473a18a491fb822c39074ce82542019-05-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1527https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe level of expression of genes of transcription factors (GATA-3, TBX21, IL-2PG), and changing of oxidative processes in ischemic stroke were studied.It was found that activation of Th2 cells (increase in the expression of transcription factor GATA-3) is observed in stroke, and suppression of Th1 cells (a decrease in the expression of IL-2 and its receptors, as well as the TBX21 gene). Increasing the expression of transcription factor GATA-3 in stroke patients underlies the increase in production in these patients of Th2-cytokines. A comparative analysis of protein oxidation in blood plasma revealed an increase in the intensity of oxidative modification of proteins in stroke patients. Investigation of glutathione content, activity of glutathione peroxidase enzymes, glutathione reductase in erythrocytes in stroke revealed a decrease in the content of glutathione and glutathione reductase and an increase in the activity of glutathione peroxidase.The findings may be useful for a better understanding of the mechanisms of stroke.H. V. ZanginyanL. M. HovsepyanG. S. KazaryanG. V. ZakaryanSPb RAACIarticlestrokegene expressionoxidative modification of proteinglutathioneImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 2, Pp 251-256 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	stroke gene expression oxidative modification of protein glutathione Immunologic diseases. Allergy RC581-607
spellingShingle	stroke gene expression oxidative modification of protein glutathione Immunologic diseases. Allergy RC581-607 H. V. Zanginyan L. M. Hovsepyan G. S. Kazaryan G. V. Zakaryan АNALYSIS OF THE EXPRESSION LEVEL OF T-CELL GENES AND OXIDATIVE PROCESSES IN STROKE
description	The level of expression of genes of transcription factors (GATA-3, TBX21, IL-2PG), and changing of oxidative processes in ischemic stroke were studied.It was found that activation of Th2 cells (increase in the expression of transcription factor GATA-3) is observed in stroke, and suppression of Th1 cells (a decrease in the expression of IL-2 and its receptors, as well as the TBX21 gene). Increasing the expression of transcription factor GATA-3 in stroke patients underlies the increase in production in these patients of Th2-cytokines. A comparative analysis of protein oxidation in blood plasma revealed an increase in the intensity of oxidative modification of proteins in stroke patients. Investigation of glutathione content, activity of glutathione peroxidase enzymes, glutathione reductase in erythrocytes in stroke revealed a decrease in the content of glutathione and glutathione reductase and an increase in the activity of glutathione peroxidase.The findings may be useful for a better understanding of the mechanisms of stroke.
format	article
author	H. V. Zanginyan L. M. Hovsepyan G. S. Kazaryan G. V. Zakaryan
author_facet	H. V. Zanginyan L. M. Hovsepyan G. S. Kazaryan G. V. Zakaryan
author_sort	H. V. Zanginyan
title	АNALYSIS OF THE EXPRESSION LEVEL OF T-CELL GENES AND OXIDATIVE PROCESSES IN STROKE
title_short	АNALYSIS OF THE EXPRESSION LEVEL OF T-CELL GENES AND OXIDATIVE PROCESSES IN STROKE
title_full	АNALYSIS OF THE EXPRESSION LEVEL OF T-CELL GENES AND OXIDATIVE PROCESSES IN STROKE
title_fullStr	АNALYSIS OF THE EXPRESSION LEVEL OF T-CELL GENES AND OXIDATIVE PROCESSES IN STROKE
title_full_unstemmed	АNALYSIS OF THE EXPRESSION LEVEL OF T-CELL GENES AND OXIDATIVE PROCESSES IN STROKE
title_sort	аnalysis of the expression level of t-cell genes and oxidative processes in stroke
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/bb3e6473a18a491fb822c39074ce8254
work_keys_str_mv	AT hvzanginyan analysisoftheexpressionleveloftcellgenesandoxidativeprocessesinstroke AT lmhovsepyan analysisoftheexpressionleveloftcellgenesandoxidativeprocessesinstroke AT gskazaryan analysisoftheexpressionleveloftcellgenesandoxidativeprocessesinstroke AT gvzakaryan analysisoftheexpressionleveloftcellgenesandoxidativeprocessesinstroke
_version_	1718422376047181824

АNALYSIS OF THE EXPRESSION LEVEL OF T-CELL GENES AND OXIDATIVE PROCESSES IN STROKE

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