PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies

PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies

Neuroinflammation has been proposed to accompany the peripheral inflammation observed in PTSD. Here, authors find lower in vivo and postmortem levels of neuroimmune marker TSPO (translocator protein) in PTSD, in association with greater PTSD severity and higher plasma CRP.

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Detalles Bibliográficos
Autores principales: Shivani Bhatt, Ansel T. Hillmer, Matthew J. Girgenti, Aleksandra Rusowicz, Michael Kapinos, Nabeel Nabulsi, Yiyun Huang, David Matuskey, Gustavo A. Angarita, Irina Esterlis, Margaret T. Davis, Steven M. Southwick, Matthew J. Friedman, Traumatic Stress Brain Study Group, Ronald S. Duman, Richard E. Carson, John H. Krystal, Robert H. Pietrzak, Kelly P. Cosgrove
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/bb3f714c9295424b9a341b4b01971c9e
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Descripción
Sumario:Neuroinflammation has been proposed to accompany the peripheral inflammation observed in PTSD. Here, authors find lower in vivo and postmortem levels of neuroimmune marker TSPO (translocator protein) in PTSD, in association with greater PTSD severity and higher plasma CRP.

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