PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies

Neuroinflammation has been proposed to accompany the peripheral inflammation observed in PTSD. Here, authors find lower in vivo and postmortem levels of neuroimmune marker TSPO (translocator protein) in PTSD, in association with greater PTSD severity and higher plasma CRP.

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Autores principales:	Shivani Bhatt, Ansel T. Hillmer, Matthew J. Girgenti, Aleksandra Rusowicz, Michael Kapinos, Nabeel Nabulsi, Yiyun Huang, David Matuskey, Gustavo A. Angarita, Irina Esterlis, Margaret T. Davis, Steven M. Southwick, Matthew J. Friedman, Traumatic Stress Brain Study Group, Ronald S. Duman, Richard E. Carson, John H. Krystal, Robert H. Pietrzak, Kelly P. Cosgrove
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bb3f714c9295424b9a341b4b01971c9e
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spelling	oai:doaj.org-article:bb3f714c9295424b9a341b4b01971c9e2021-12-02T15:43:22ZPTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies10.1038/s41467-020-15930-52041-1723https://doaj.org/article/bb3f714c9295424b9a341b4b01971c9e2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15930-5https://doaj.org/toc/2041-1723Neuroinflammation has been proposed to accompany the peripheral inflammation observed in PTSD. Here, authors find lower in vivo and postmortem levels of neuroimmune marker TSPO (translocator protein) in PTSD, in association with greater PTSD severity and higher plasma CRP.Shivani BhattAnsel T. HillmerMatthew J. GirgentiAleksandra RusowiczMichael KapinosNabeel NabulsiYiyun HuangDavid MatuskeyGustavo A. AngaritaIrina EsterlisMargaret T. DavisSteven M. SouthwickMatthew J. FriedmanTraumatic Stress Brain Study GroupRonald S. DumanRichard E. CarsonJohn H. KrystalRobert H. PietrzakKelly P. CosgroveNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shivani Bhatt Ansel T. Hillmer Matthew J. Girgenti Aleksandra Rusowicz Michael Kapinos Nabeel Nabulsi Yiyun Huang David Matuskey Gustavo A. Angarita Irina Esterlis Margaret T. Davis Steven M. Southwick Matthew J. Friedman Traumatic Stress Brain Study Group Ronald S. Duman Richard E. Carson John H. Krystal Robert H. Pietrzak Kelly P. Cosgrove PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies
description	Neuroinflammation has been proposed to accompany the peripheral inflammation observed in PTSD. Here, authors find lower in vivo and postmortem levels of neuroimmune marker TSPO (translocator protein) in PTSD, in association with greater PTSD severity and higher plasma CRP.
format	article
author	Shivani Bhatt Ansel T. Hillmer Matthew J. Girgenti Aleksandra Rusowicz Michael Kapinos Nabeel Nabulsi Yiyun Huang David Matuskey Gustavo A. Angarita Irina Esterlis Margaret T. Davis Steven M. Southwick Matthew J. Friedman Traumatic Stress Brain Study Group Ronald S. Duman Richard E. Carson John H. Krystal Robert H. Pietrzak Kelly P. Cosgrove
author_facet	Shivani Bhatt Ansel T. Hillmer Matthew J. Girgenti Aleksandra Rusowicz Michael Kapinos Nabeel Nabulsi Yiyun Huang David Matuskey Gustavo A. Angarita Irina Esterlis Margaret T. Davis Steven M. Southwick Matthew J. Friedman Traumatic Stress Brain Study Group Ronald S. Duman Richard E. Carson John H. Krystal Robert H. Pietrzak Kelly P. Cosgrove
author_sort	Shivani Bhatt
title	PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies
title_short	PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies
title_full	PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies
title_fullStr	PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies
title_full_unstemmed	PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies
title_sort	ptsd is associated with neuroimmune suppression: evidence from pet imaging and postmortem transcriptomic studies
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bb3f714c9295424b9a341b4b01971c9e
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_version_	1718385832185823232

PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies

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