Effect of a Single Preoperative Dose of Oral Antibiotic to Reduce the Incidence of Surgical Site Infection Following Below-knee Dermatological Flap and Graft Repair

Background: Surgical site infection (SSI) rates for below-knee dermatological surgery are unacceptably high, particularly following complex flap and graft closures. The role of antibiotic prophylaxis for these surgical cases is uncertain. Objective: To determine whether SSI following complex dermat...

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Autores principales:	Helena Rosengren, Clare F. Heal, Petra G. Buttner
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2019
Materias:	antibiotic prophylaxis surgical site infection dermatological surgical wound infection operative surgical procedures grafts Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/bb4038ffa73043bbb754f5dea492535d
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spelling	oai:doaj.org-article:bb4038ffa73043bbb754f5dea492535d2021-11-17T08:29:45ZEffect of a Single Preoperative Dose of Oral Antibiotic to Reduce the Incidence of Surgical Site Infection Following Below-knee Dermatological Flap and Graft Repair10.5826/dpc.0901a082160-9381https://doaj.org/article/bb4038ffa73043bbb754f5dea492535d2019-01-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/561https://doaj.org/toc/2160-9381 Background: Surgical site infection (SSI) rates for below-knee dermatological surgery are unacceptably high, particularly following complex flap and graft closures. The role of antibiotic prophylaxis for these surgical cases is uncertain. Objective: To determine whether SSI following complex dermatological closures on the leg could be reduced by antibiotic prophylaxis administered as a single oral preoperative dose. Methods: A total of 115 participants were randomized to 2 g of oral cephalexin or placebo 40-60 minutes prior to surgical incision in a prospective, randomized, double-blind, placebo-controlled trial at a primary care skin cancer clinic in North Queensland, Australia. Results: Overall 17/55 (30.9%) controls and 14/55 (25.5%) intervention participants developed infection (P = 0.525). There was no difference between the study groups in adverse symptoms that could be attributed to high-dose antibiotic administration (P = 1). Conclusion: A single oral 2-g dose of cephalexin given before complex below-knee dermatological closure did not reduce SSI. Helena RosengrenClare F. HealPetra G. ButtnerMattioli1885articleantibiotic prophylaxissurgical site infectiondermatological surgical wound infectionoperative surgical proceduresgraftsDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 9, Iss 1 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibiotic prophylaxis surgical site infection dermatological surgical wound infection operative surgical procedures grafts Dermatology RL1-803
spellingShingle	antibiotic prophylaxis surgical site infection dermatological surgical wound infection operative surgical procedures grafts Dermatology RL1-803 Helena Rosengren Clare F. Heal Petra G. Buttner Effect of a Single Preoperative Dose of Oral Antibiotic to Reduce the Incidence of Surgical Site Infection Following Below-knee Dermatological Flap and Graft Repair
description	Background: Surgical site infection (SSI) rates for below-knee dermatological surgery are unacceptably high, particularly following complex flap and graft closures. The role of antibiotic prophylaxis for these surgical cases is uncertain. Objective: To determine whether SSI following complex dermatological closures on the leg could be reduced by antibiotic prophylaxis administered as a single oral preoperative dose. Methods: A total of 115 participants were randomized to 2 g of oral cephalexin or placebo 40-60 minutes prior to surgical incision in a prospective, randomized, double-blind, placebo-controlled trial at a primary care skin cancer clinic in North Queensland, Australia. Results: Overall 17/55 (30.9%) controls and 14/55 (25.5%) intervention participants developed infection (P = 0.525). There was no difference between the study groups in adverse symptoms that could be attributed to high-dose antibiotic administration (P = 1). Conclusion: A single oral 2-g dose of cephalexin given before complex below-knee dermatological closure did not reduce SSI.
format	article
author	Helena Rosengren Clare F. Heal Petra G. Buttner
author_facet	Helena Rosengren Clare F. Heal Petra G. Buttner
author_sort	Helena Rosengren
title	Effect of a Single Preoperative Dose of Oral Antibiotic to Reduce the Incidence of Surgical Site Infection Following Below-knee Dermatological Flap and Graft Repair
title_short	Effect of a Single Preoperative Dose of Oral Antibiotic to Reduce the Incidence of Surgical Site Infection Following Below-knee Dermatological Flap and Graft Repair
title_full	Effect of a Single Preoperative Dose of Oral Antibiotic to Reduce the Incidence of Surgical Site Infection Following Below-knee Dermatological Flap and Graft Repair
title_fullStr	Effect of a Single Preoperative Dose of Oral Antibiotic to Reduce the Incidence of Surgical Site Infection Following Below-knee Dermatological Flap and Graft Repair
title_full_unstemmed	Effect of a Single Preoperative Dose of Oral Antibiotic to Reduce the Incidence of Surgical Site Infection Following Below-knee Dermatological Flap and Graft Repair
title_sort	effect of a single preoperative dose of oral antibiotic to reduce the incidence of surgical site infection following below-knee dermatological flap and graft repair
publisher	Mattioli1885
publishDate	2019
url	https://doaj.org/article/bb4038ffa73043bbb754f5dea492535d
work_keys_str_mv	AT helenarosengren effectofasinglepreoperativedoseoforalantibiotictoreducetheincidenceofsurgicalsiteinfectionfollowingbelowkneedermatologicalflapandgraftrepair AT clarefheal effectofasinglepreoperativedoseoforalantibiotictoreducetheincidenceofsurgicalsiteinfectionfollowingbelowkneedermatologicalflapandgraftrepair AT petragbuttner effectofasinglepreoperativedoseoforalantibiotictoreducetheincidenceofsurgicalsiteinfectionfollowingbelowkneedermatologicalflapandgraftrepair
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Effect of a Single Preoperative Dose of Oral Antibiotic to Reduce the Incidence of Surgical Site Infection Following Below-knee Dermatological Flap and Graft Repair

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