Early visual processing for low spatial frequency fearful face is correlated with cortical volume in patients with schizophrenia

Jung Suk Lee,1 Gewnhi Park,2 Myeong Ju Song,3 Kee-Hong Choi,4 Seung-Hwan Lee5,6 1Department of Psychiatry, National Health Insurance Service Ilsan Hospital, Goyang, Republic of Korea; 2Department of Psychology, Azusa Pacific University, Azusa, CA, USA; 3Department of Neuropsychiatry, Seoul National...

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Autores principales:	Lee JS, Park G, Song MJ, Choi KH, Lee SH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Event-related potential visual processing magnocellular voxel-based morphometry schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/bb410baaebcd4d40a2c8bd373e3545a6
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spelling	oai:doaj.org-article:bb410baaebcd4d40a2c8bd373e3545a62021-12-02T00:23:48ZEarly visual processing for low spatial frequency fearful face is correlated with cortical volume in patients with schizophrenia1178-2021https://doaj.org/article/bb410baaebcd4d40a2c8bd373e3545a62015-12-01T00:00:00Zhttps://www.dovepress.com/early-visual-processing-for-low-spatial-frequency-fearful-face-is-corr-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jung Suk Lee,1 Gewnhi Park,2 Myeong Ju Song,3 Kee-Hong Choi,4 Seung-Hwan Lee5,6 1Department of Psychiatry, National Health Insurance Service Ilsan Hospital, Goyang, Republic of Korea; 2Department of Psychology, Azusa Pacific University, Azusa, CA, USA; 3Department of Neuropsychiatry, Seoul National University Hospital, 4Department of Psychology, Korea University, Seoul, Republic of Korea; 5Clinical Emotion and Cognition Research Laboratory, Goyang, Republic of Korea; 6Department of Psychiatry, Inje University, Ilsan-Paik Hospital, Goyang, Republic of Korea Abstract: Patients with schizophrenia present with dysfunction of the magnocellular pathway, which might impair their early visual processing. We explored the relationship between functional abnormality of early visual processing and brain volumetric changes in schizophrenia. Eighteen patients and 16 healthy controls underwent electroencephalographic recordings and high-resolution magnetic resonance imaging. During electroencephalographic recordings, participants passively viewed neutral or fearful faces with broad, high, or low spatial frequency characteristics. Voxel-based morphometry was performed to investigate brain volume correlates of visual processing deficits. Event related potential analysis suggested that patients with schizophrenia had relatively impaired P100 processing of low spatial frequency fearful face stimuli compared with healthy controls; patients’ gray-matter volumes in the dorsolateral and medial prefrontal cortices positively correlated with this amplitude. In addition, patients’ gray-matter volume in the right cuneus positively correlated with the P100 amplitude in the left hemisphere for the high spatial frequency neutral face condition and that in the left dorsolateral prefrontal cortex negatively correlated with the negative score of the Positive and Negative Syndrome Scale. No significant correlations were observed in healthy controls. This study suggests that the cuneus and prefrontal cortex are significantly involved with the early visual processing of magnocellular input in patients with schizophrenia. Keywords: event-related potential, visual processing, magnocellular, voxel-based morphometry, schizophreniaLee JSPark GSong MJChoi KHLee SHDove Medical PressarticleEvent-related potentialvisual processingmagnocellularvoxel-based morphometryschizophreniaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1-14 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Event-related potential visual processing magnocellular voxel-based morphometry schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Event-related potential visual processing magnocellular voxel-based morphometry schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Lee JS Park G Song MJ Choi KH Lee SH Early visual processing for low spatial frequency fearful face is correlated with cortical volume in patients with schizophrenia
description	Jung Suk Lee,1 Gewnhi Park,2 Myeong Ju Song,3 Kee-Hong Choi,4 Seung-Hwan Lee5,6 1Department of Psychiatry, National Health Insurance Service Ilsan Hospital, Goyang, Republic of Korea; 2Department of Psychology, Azusa Pacific University, Azusa, CA, USA; 3Department of Neuropsychiatry, Seoul National University Hospital, 4Department of Psychology, Korea University, Seoul, Republic of Korea; 5Clinical Emotion and Cognition Research Laboratory, Goyang, Republic of Korea; 6Department of Psychiatry, Inje University, Ilsan-Paik Hospital, Goyang, Republic of Korea Abstract: Patients with schizophrenia present with dysfunction of the magnocellular pathway, which might impair their early visual processing. We explored the relationship between functional abnormality of early visual processing and brain volumetric changes in schizophrenia. Eighteen patients and 16 healthy controls underwent electroencephalographic recordings and high-resolution magnetic resonance imaging. During electroencephalographic recordings, participants passively viewed neutral or fearful faces with broad, high, or low spatial frequency characteristics. Voxel-based morphometry was performed to investigate brain volume correlates of visual processing deficits. Event related potential analysis suggested that patients with schizophrenia had relatively impaired P100 processing of low spatial frequency fearful face stimuli compared with healthy controls; patients’ gray-matter volumes in the dorsolateral and medial prefrontal cortices positively correlated with this amplitude. In addition, patients’ gray-matter volume in the right cuneus positively correlated with the P100 amplitude in the left hemisphere for the high spatial frequency neutral face condition and that in the left dorsolateral prefrontal cortex negatively correlated with the negative score of the Positive and Negative Syndrome Scale. No significant correlations were observed in healthy controls. This study suggests that the cuneus and prefrontal cortex are significantly involved with the early visual processing of magnocellular input in patients with schizophrenia. Keywords: event-related potential, visual processing, magnocellular, voxel-based morphometry, schizophrenia
format	article
author	Lee JS Park G Song MJ Choi KH Lee SH
author_facet	Lee JS Park G Song MJ Choi KH Lee SH
author_sort	Lee JS
title	Early visual processing for low spatial frequency fearful face is correlated with cortical volume in patients with schizophrenia
title_short	Early visual processing for low spatial frequency fearful face is correlated with cortical volume in patients with schizophrenia
title_full	Early visual processing for low spatial frequency fearful face is correlated with cortical volume in patients with schizophrenia
title_fullStr	Early visual processing for low spatial frequency fearful face is correlated with cortical volume in patients with schizophrenia
title_full_unstemmed	Early visual processing for low spatial frequency fearful face is correlated with cortical volume in patients with schizophrenia
title_sort	early visual processing for low spatial frequency fearful face is correlated with cortical volume in patients with schizophrenia
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/bb410baaebcd4d40a2c8bd373e3545a6
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Early visual processing for low spatial frequency fearful face is correlated with cortical volume in patients with schizophrenia

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