Risk factors associated with surgical intervention in childhood pleural tuberculosis

Abstract Surgical intervention use is common in the management of childhood pleural tuberculosis (TB), however, its associated risk factors remain unclear. Between January 2006 and December 2019, consecutive children patients (≤ 15 years old) who had a diagnosis of pleural TB were included for the a...

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Autores principales:	Ming Zhou, Shi-Feng Ren, Huai-Zheng Gong, Mao-Shui Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bb424094406b45569bd5e801f1bf1ed8
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spelling	oai:doaj.org-article:bb424094406b45569bd5e801f1bf1ed82021-12-02T14:06:50ZRisk factors associated with surgical intervention in childhood pleural tuberculosis10.1038/s41598-021-82936-42045-2322https://doaj.org/article/bb424094406b45569bd5e801f1bf1ed82021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82936-4https://doaj.org/toc/2045-2322Abstract Surgical intervention use is common in the management of childhood pleural tuberculosis (TB), however, its associated risk factors remain unclear. Between January 2006 and December 2019, consecutive children patients (≤ 15 years old) who had a diagnosis of pleural TB were included for the analysis. Surgical intervention was defined as debridement (such as breaking loculations), decortication, and thoracic surgery (such as lobectomy or segmental resection). Patients undergoing surgery were included as surgical group, without surgery were classified as non-surgical group, surgical risk factors were then estimated. Univariate and multivariate logistic regression analysis were performed to evaluate the risk factors for surgical interventions. A total of 154 children diagnosed as pleural TB (definite, 123 cases; possible, 31 cases) were included in our study. Of them, 29 patients (18.8%) were classified as surgical group and 125 patients (81.2%) were classified as non-surgical group. Surgical treatments were analyzed in 29 (18.8%) patients, including debridement (n = 4), decortication (n = 21), and thoracic surgery (n = 4). Further multivariate analysis revealed that empyema (age- and sex-adjusted OR = 27.3, 95% CI 8.6, 87.1; P < 0.001) and frequency of hospitalization (age- and sex-adjusted OR = 1.53, 95% CI 1.11, 2.11; P < 0.01) were associated with the use of surgical interventions in children with pleural TB. In China, surgical interventions are still required in a significant proportion of children with pleural TB, and the surgical risk is found to be associated with the frequency of hospitalization and empyema. These findings may be helpful to improve the management of children with pleural TB and minimize the risk of poor outcomes.Ming ZhouShi-Feng RenHuai-Zheng GongMao-Shui WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ming Zhou Shi-Feng Ren Huai-Zheng Gong Mao-Shui Wang Risk factors associated with surgical intervention in childhood pleural tuberculosis
description	Abstract Surgical intervention use is common in the management of childhood pleural tuberculosis (TB), however, its associated risk factors remain unclear. Between January 2006 and December 2019, consecutive children patients (≤ 15 years old) who had a diagnosis of pleural TB were included for the analysis. Surgical intervention was defined as debridement (such as breaking loculations), decortication, and thoracic surgery (such as lobectomy or segmental resection). Patients undergoing surgery were included as surgical group, without surgery were classified as non-surgical group, surgical risk factors were then estimated. Univariate and multivariate logistic regression analysis were performed to evaluate the risk factors for surgical interventions. A total of 154 children diagnosed as pleural TB (definite, 123 cases; possible, 31 cases) were included in our study. Of them, 29 patients (18.8%) were classified as surgical group and 125 patients (81.2%) were classified as non-surgical group. Surgical treatments were analyzed in 29 (18.8%) patients, including debridement (n = 4), decortication (n = 21), and thoracic surgery (n = 4). Further multivariate analysis revealed that empyema (age- and sex-adjusted OR = 27.3, 95% CI 8.6, 87.1; P < 0.001) and frequency of hospitalization (age- and sex-adjusted OR = 1.53, 95% CI 1.11, 2.11; P < 0.01) were associated with the use of surgical interventions in children with pleural TB. In China, surgical interventions are still required in a significant proportion of children with pleural TB, and the surgical risk is found to be associated with the frequency of hospitalization and empyema. These findings may be helpful to improve the management of children with pleural TB and minimize the risk of poor outcomes.
format	article
author	Ming Zhou Shi-Feng Ren Huai-Zheng Gong Mao-Shui Wang
author_facet	Ming Zhou Shi-Feng Ren Huai-Zheng Gong Mao-Shui Wang
author_sort	Ming Zhou
title	Risk factors associated with surgical intervention in childhood pleural tuberculosis
title_short	Risk factors associated with surgical intervention in childhood pleural tuberculosis
title_full	Risk factors associated with surgical intervention in childhood pleural tuberculosis
title_fullStr	Risk factors associated with surgical intervention in childhood pleural tuberculosis
title_full_unstemmed	Risk factors associated with surgical intervention in childhood pleural tuberculosis
title_sort	risk factors associated with surgical intervention in childhood pleural tuberculosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bb424094406b45569bd5e801f1bf1ed8
work_keys_str_mv	AT mingzhou riskfactorsassociatedwithsurgicalinterventioninchildhoodpleuraltuberculosis AT shifengren riskfactorsassociatedwithsurgicalinterventioninchildhoodpleuraltuberculosis AT huaizhenggong riskfactorsassociatedwithsurgicalinterventioninchildhoodpleuraltuberculosis AT maoshuiwang riskfactorsassociatedwithsurgicalinterventioninchildhoodpleuraltuberculosis
_version_	1718391986670534656

Risk factors associated with surgical intervention in childhood pleural tuberculosis

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