SS18 regulates pluripotent-somatic transition through phase separation

SS18 regulates pluripotent-somatic transition through phase separation

Emerging evidence suggests that exit from pluripotency is a regulated, rather than passive process. Here the authors identify a requirement for SS18-mediated Brg/Brahma-associated factors (BAF) chromatin remodeling complex assembly during exit from pluripotency, and that SS18 promotes BAF assembly t...

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Autores principales: Junqi Kuang, Ziwei Zhai, Pengli Li, Ruona Shi, Wenjing Guo, Yuxiang Yao, Jing Guo, Guoqing Zhao, Jiangpin He, Shuyang Xu, Chuman Wu, Shengyong Yu, Chunhua Zhou, Linlin Wu, Yue Qin, Baomei Cai, Wei Li, Zichao Wu, Xiaoxi Li, Shilong Chu, Tingting Yang, Bo Wang, Shangtao Cao, Dongwei Li, Xiaofei Zhang, Jiekai Chen, Jing Liu, Duanqing Pei
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/bb43a8e0c9ca42d389c825e15445163f
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spelling oai:doaj.org-article:bb43a8e0c9ca42d389c825e15445163f2021-12-02T16:10:47ZSS18 regulates pluripotent-somatic transition through phase separation10.1038/s41467-021-24373-52041-1723https://doaj.org/article/bb43a8e0c9ca42d389c825e15445163f2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24373-5https://doaj.org/toc/2041-1723Emerging evidence suggests that exit from pluripotency is a regulated, rather than passive process. Here the authors identify a requirement for SS18-mediated Brg/Brahma-associated factors (BAF) chromatin remodeling complex assembly during exit from pluripotency, and that SS18 promotes BAF assembly through liquidliquid phase separation.Junqi KuangZiwei ZhaiPengli LiRuona ShiWenjing GuoYuxiang YaoJing GuoGuoqing ZhaoJiangpin HeShuyang XuChuman WuShengyong YuChunhua ZhouLinlin WuYue QinBaomei CaiWei LiZichao WuXiaoxi LiShilong ChuTingting YangBo WangShangtao CaoDongwei LiXiaofei ZhangJiekai ChenJing LiuDuanqing PeiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Junqi Kuang
Ziwei Zhai
Pengli Li
Ruona Shi
Wenjing Guo
Yuxiang Yao
Jing Guo
Guoqing Zhao
Jiangpin He
Shuyang Xu
Chuman Wu
Shengyong Yu
Chunhua Zhou
Linlin Wu
Yue Qin
Baomei Cai
Wei Li
Zichao Wu
Xiaoxi Li
Shilong Chu
Tingting Yang
Bo Wang
Shangtao Cao
Dongwei Li
Xiaofei Zhang
Jiekai Chen
Jing Liu
Duanqing Pei
SS18 regulates pluripotent-somatic transition through phase separation
description Emerging evidence suggests that exit from pluripotency is a regulated, rather than passive process. Here the authors identify a requirement for SS18-mediated Brg/Brahma-associated factors (BAF) chromatin remodeling complex assembly during exit from pluripotency, and that SS18 promotes BAF assembly through liquidliquid phase separation.
format article
author Junqi Kuang
Ziwei Zhai
Pengli Li
Ruona Shi
Wenjing Guo
Yuxiang Yao
Jing Guo
Guoqing Zhao
Jiangpin He
Shuyang Xu
Chuman Wu
Shengyong Yu
Chunhua Zhou
Linlin Wu
Yue Qin
Baomei Cai
Wei Li
Zichao Wu
Xiaoxi Li
Shilong Chu
Tingting Yang
Bo Wang
Shangtao Cao
Dongwei Li
Xiaofei Zhang
Jiekai Chen
Jing Liu
Duanqing Pei
author_facet Junqi Kuang
Ziwei Zhai
Pengli Li
Ruona Shi
Wenjing Guo
Yuxiang Yao
Jing Guo
Guoqing Zhao
Jiangpin He
Shuyang Xu
Chuman Wu
Shengyong Yu
Chunhua Zhou
Linlin Wu
Yue Qin
Baomei Cai
Wei Li
Zichao Wu
Xiaoxi Li
Shilong Chu
Tingting Yang
Bo Wang
Shangtao Cao
Dongwei Li
Xiaofei Zhang
Jiekai Chen
Jing Liu
Duanqing Pei
author_sort Junqi Kuang
title SS18 regulates pluripotent-somatic transition through phase separation
title_short SS18 regulates pluripotent-somatic transition through phase separation
title_full SS18 regulates pluripotent-somatic transition through phase separation
title_fullStr SS18 regulates pluripotent-somatic transition through phase separation
title_full_unstemmed SS18 regulates pluripotent-somatic transition through phase separation
title_sort ss18 regulates pluripotent-somatic transition through phase separation
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/bb43a8e0c9ca42d389c825e15445163f
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