The Pathology of Type 2 Inflammation-Associated Itch in Atopic Dermatitis

Accumulated evidence on type 2 inflammation-associated itch in atopic dermatitis has recently been reported. Crosstalk between the immune and nervous systems (neuroimmune interactions) is prominent in atopic dermatitis research, particularly regarding itch and inflammation. A comprehensive understan...

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Autores principales:	Catharina Sagita Moniaga, Mitsutoshi Tominaga, Kenji Takamori
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	atopic dermatitis biologic agents neuroimmune interactions type 2 inflammation Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/bb49359020b24e7883d35e56f3f9897d
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spelling	oai:doaj.org-article:bb49359020b24e7883d35e56f3f9897d2021-11-25T17:21:32ZThe Pathology of Type 2 Inflammation-Associated Itch in Atopic Dermatitis10.3390/diagnostics111120902075-4418https://doaj.org/article/bb49359020b24e7883d35e56f3f9897d2021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2090https://doaj.org/toc/2075-4418Accumulated evidence on type 2 inflammation-associated itch in atopic dermatitis has recently been reported. Crosstalk between the immune and nervous systems (neuroimmune interactions) is prominent in atopic dermatitis research, particularly regarding itch and inflammation. A comprehensive understanding of bidirectional neuroimmune interactions will provide insights into the pathogenesis of itch and its treatment. There is currently no agreed cure for itch in atopic dermatitis; however, increasing numbers of novel and targeted biologic agents have potential for its management and are in the advanced stages of clinical trials. In this review, we summarize and discuss advances in our understanding of type 2 inflammation-associated itch and implications for its management and treatment in patients with atopic dermatitis.Catharina Sagita MoniagaMitsutoshi TominagaKenji TakamoriMDPI AGarticleatopic dermatitisbiologic agentsneuroimmune interactionstype 2 inflammationMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2090, p 2090 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atopic dermatitis biologic agents neuroimmune interactions type 2 inflammation Medicine (General) R5-920
spellingShingle	atopic dermatitis biologic agents neuroimmune interactions type 2 inflammation Medicine (General) R5-920 Catharina Sagita Moniaga Mitsutoshi Tominaga Kenji Takamori The Pathology of Type 2 Inflammation-Associated Itch in Atopic Dermatitis
description	Accumulated evidence on type 2 inflammation-associated itch in atopic dermatitis has recently been reported. Crosstalk between the immune and nervous systems (neuroimmune interactions) is prominent in atopic dermatitis research, particularly regarding itch and inflammation. A comprehensive understanding of bidirectional neuroimmune interactions will provide insights into the pathogenesis of itch and its treatment. There is currently no agreed cure for itch in atopic dermatitis; however, increasing numbers of novel and targeted biologic agents have potential for its management and are in the advanced stages of clinical trials. In this review, we summarize and discuss advances in our understanding of type 2 inflammation-associated itch and implications for its management and treatment in patients with atopic dermatitis.
format	article
author	Catharina Sagita Moniaga Mitsutoshi Tominaga Kenji Takamori
author_facet	Catharina Sagita Moniaga Mitsutoshi Tominaga Kenji Takamori
author_sort	Catharina Sagita Moniaga
title	The Pathology of Type 2 Inflammation-Associated Itch in Atopic Dermatitis
title_short	The Pathology of Type 2 Inflammation-Associated Itch in Atopic Dermatitis
title_full	The Pathology of Type 2 Inflammation-Associated Itch in Atopic Dermatitis
title_fullStr	The Pathology of Type 2 Inflammation-Associated Itch in Atopic Dermatitis
title_full_unstemmed	The Pathology of Type 2 Inflammation-Associated Itch in Atopic Dermatitis
title_sort	pathology of type 2 inflammation-associated itch in atopic dermatitis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bb49359020b24e7883d35e56f3f9897d
work_keys_str_mv	AT catharinasagitamoniaga thepathologyoftype2inflammationassociateditchinatopicdermatitis AT mitsutoshitominaga thepathologyoftype2inflammationassociateditchinatopicdermatitis AT kenjitakamori thepathologyoftype2inflammationassociateditchinatopicdermatitis AT catharinasagitamoniaga pathologyoftype2inflammationassociateditchinatopicdermatitis AT mitsutoshitominaga pathologyoftype2inflammationassociateditchinatopicdermatitis AT kenjitakamori pathologyoftype2inflammationassociateditchinatopicdermatitis
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The Pathology of Type 2 Inflammation-Associated Itch in Atopic Dermatitis

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