Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy
Structural changes to the left ventricle are characteristic of dilated cardiomyopathy (DCM), a disease for which many rare genetic variants are known. Here, Pirruccello et al. report GWAS of seven cardiac MRI measurements in the left ventricle and describe shared loci and polygenic association with...
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Nature Portfolio
2020
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oai:doaj.org-article:bb4e68aedf3c4014874c9837a0e34e342021-12-02T15:37:15ZAnalysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy10.1038/s41467-020-15823-72041-1723https://doaj.org/article/bb4e68aedf3c4014874c9837a0e34e342020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15823-7https://doaj.org/toc/2041-1723Structural changes to the left ventricle are characteristic of dilated cardiomyopathy (DCM), a disease for which many rare genetic variants are known. Here, Pirruccello et al. report GWAS of seven cardiac MRI measurements in the left ventricle and describe shared loci and polygenic association with DCM.James P. PirruccelloAlexander BickMinxian WangMark ChaffinSamuel FriedmanJie YaoXiuqing GuoBharath Ambale VenkateshKent D. TaylorWendy S. PostStephen RichJoao A. C. LimaJerome I. RotterAnthony PhilippakisSteven A. LubitzPatrick T. EllinorAmit V. KheraSekar KathiresanKrishna G. AragamNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020) |
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DOAJ |
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| topic |
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| spellingShingle |
Science Q James P. Pirruccello Alexander Bick Minxian Wang Mark Chaffin Samuel Friedman Jie Yao Xiuqing Guo Bharath Ambale Venkatesh Kent D. Taylor Wendy S. Post Stephen Rich Joao A. C. Lima Jerome I. Rotter Anthony Philippakis Steven A. Lubitz Patrick T. Ellinor Amit V. Khera Sekar Kathiresan Krishna G. Aragam Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy |
| description |
Structural changes to the left ventricle are characteristic of dilated cardiomyopathy (DCM), a disease for which many rare genetic variants are known. Here, Pirruccello et al. report GWAS of seven cardiac MRI measurements in the left ventricle and describe shared loci and polygenic association with DCM. |
| format |
article |
| author |
James P. Pirruccello Alexander Bick Minxian Wang Mark Chaffin Samuel Friedman Jie Yao Xiuqing Guo Bharath Ambale Venkatesh Kent D. Taylor Wendy S. Post Stephen Rich Joao A. C. Lima Jerome I. Rotter Anthony Philippakis Steven A. Lubitz Patrick T. Ellinor Amit V. Khera Sekar Kathiresan Krishna G. Aragam |
| author_facet |
James P. Pirruccello Alexander Bick Minxian Wang Mark Chaffin Samuel Friedman Jie Yao Xiuqing Guo Bharath Ambale Venkatesh Kent D. Taylor Wendy S. Post Stephen Rich Joao A. C. Lima Jerome I. Rotter Anthony Philippakis Steven A. Lubitz Patrick T. Ellinor Amit V. Khera Sekar Kathiresan Krishna G. Aragam |
| author_sort |
James P. Pirruccello |
| title |
Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy |
| title_short |
Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy |
| title_full |
Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy |
| title_fullStr |
Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy |
| title_full_unstemmed |
Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy |
| title_sort |
analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/bb4e68aedf3c4014874c9837a0e34e34 |
| work_keys_str_mv |
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