The NUCKS1-SKP2-p21/p27 axis controls S phase entry

The NUCKS1-SKP2-p21/p27 axis controls S phase entry

Entry into S phase of the cell cycle is regulated positively by mitogens and negatively by DNA damage; however, how balance of these signals is achieved is not well known. Here the authors show that the NUCKS1-SKP2- p21/p27 axis integrates this information, where the NUCKS1 transcription factor affe...

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Main Authors: Samuel Hume, Claudia P. Grou, Pauline Lascaux, Vincenzo D’Angiolella, Arnaud J. Legrand, Kristijan Ramadan, Grigory L. Dianov
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
Q
Online Access:https://doaj.org/article/bb543b94e36042c6a1671243251e6cf4
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spelling oai:doaj.org-article:bb543b94e36042c6a1671243251e6cf42021-12-05T12:22:37ZThe NUCKS1-SKP2-p21/p27 axis controls S phase entry10.1038/s41467-021-27124-82041-1723https://doaj.org/article/bb543b94e36042c6a1671243251e6cf42021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27124-8https://doaj.org/toc/2041-1723Entry into S phase of the cell cycle is regulated positively by mitogens and negatively by DNA damage; however, how balance of these signals is achieved is not well known. Here the authors show that the NUCKS1-SKP2- p21/p27 axis integrates this information, where the NUCKS1 transcription factor affects levels of p21/p27 to readout the mitogen:DNA damage balance and regulate S phase entry decision.Samuel HumeClaudia P. GrouPauline LascauxVincenzo D’AngiolellaArnaud J. LegrandKristijan RamadanGrigory L. DianovNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Samuel Hume
Claudia P. Grou
Pauline Lascaux
Vincenzo D’Angiolella
Arnaud J. Legrand
Kristijan Ramadan
Grigory L. Dianov
The NUCKS1-SKP2-p21/p27 axis controls S phase entry
description Entry into S phase of the cell cycle is regulated positively by mitogens and negatively by DNA damage; however, how balance of these signals is achieved is not well known. Here the authors show that the NUCKS1-SKP2- p21/p27 axis integrates this information, where the NUCKS1 transcription factor affects levels of p21/p27 to readout the mitogen:DNA damage balance and regulate S phase entry decision.
format article
author Samuel Hume
Claudia P. Grou
Pauline Lascaux
Vincenzo D’Angiolella
Arnaud J. Legrand
Kristijan Ramadan
Grigory L. Dianov
author_facet Samuel Hume
Claudia P. Grou
Pauline Lascaux
Vincenzo D’Angiolella
Arnaud J. Legrand
Kristijan Ramadan
Grigory L. Dianov
author_sort Samuel Hume
title The NUCKS1-SKP2-p21/p27 axis controls S phase entry
title_short The NUCKS1-SKP2-p21/p27 axis controls S phase entry
title_full The NUCKS1-SKP2-p21/p27 axis controls S phase entry
title_fullStr The NUCKS1-SKP2-p21/p27 axis controls S phase entry
title_full_unstemmed The NUCKS1-SKP2-p21/p27 axis controls S phase entry
title_sort nucks1-skp2-p21/p27 axis controls s phase entry
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/bb543b94e36042c6a1671243251e6cf4
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