Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production

The cellular identity and function of the pancreatic polypeptide (Ppy)-producing γ-cells are incompletely understood. Here the authors show that these cells are heterogeneous and display adaptive plasticity to engage in insulin production following β-cell injury, but loss of the Ppy gene or γ-cells...

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Autores principales:	Marta Perez-Frances, Léon van Gurp, Maria Valentina Abate, Valentina Cigliola, Kenichiro Furuyama, Eva Bru-Tari, Daniel Oropeza, Taïna Carreaux, Yoshio Fujitani, Fabrizio Thorel, Pedro L. Herrera
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bb558558df6c406fb5d12e3bdfc0c628
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spelling	oai:doaj.org-article:bb558558df6c406fb5d12e3bdfc0c6282021-12-02T16:26:32ZPancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production10.1038/s41467-021-24788-02041-1723https://doaj.org/article/bb558558df6c406fb5d12e3bdfc0c6282021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24788-0https://doaj.org/toc/2041-1723The cellular identity and function of the pancreatic polypeptide (Ppy)-producing γ-cells are incompletely understood. Here the authors show that these cells are heterogeneous and display adaptive plasticity to engage in insulin production following β-cell injury, but loss of the Ppy gene or γ-cells in mice does not affect weight or glycemia under basal conditions.Marta Perez-FrancesLéon van GurpMaria Valentina AbateValentina CigliolaKenichiro FuruyamaEva Bru-TariDaniel OropezaTaïna CarreauxYoshio FujitaniFabrizio ThorelPedro L. HerreraNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marta Perez-Frances Léon van Gurp Maria Valentina Abate Valentina Cigliola Kenichiro Furuyama Eva Bru-Tari Daniel Oropeza Taïna Carreaux Yoshio Fujitani Fabrizio Thorel Pedro L. Herrera Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production
description	The cellular identity and function of the pancreatic polypeptide (Ppy)-producing γ-cells are incompletely understood. Here the authors show that these cells are heterogeneous and display adaptive plasticity to engage in insulin production following β-cell injury, but loss of the Ppy gene or γ-cells in mice does not affect weight or glycemia under basal conditions.
format	article
author	Marta Perez-Frances Léon van Gurp Maria Valentina Abate Valentina Cigliola Kenichiro Furuyama Eva Bru-Tari Daniel Oropeza Taïna Carreaux Yoshio Fujitani Fabrizio Thorel Pedro L. Herrera
author_facet	Marta Perez-Frances Léon van Gurp Maria Valentina Abate Valentina Cigliola Kenichiro Furuyama Eva Bru-Tari Daniel Oropeza Taïna Carreaux Yoshio Fujitani Fabrizio Thorel Pedro L. Herrera
author_sort	Marta Perez-Frances
title	Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production
title_short	Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production
title_full	Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production
title_fullStr	Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production
title_full_unstemmed	Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production
title_sort	pancreatic ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bb558558df6c406fb5d12e3bdfc0c628
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Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production

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