A novel preparation method for drug nanocrystals and characterization by ultrasonic spray assisted electrostatic adsorption

Bing Gao,1–3 Jun Wang,2 Dunju Wang,1,2 Ziqiang Zhu,1,2 Zhiqiang Qiao,2 Guangcheng Yang,2 Fude Nie21School of Material Science and Engineering, Southwest University of Science and Technology, Mianyang, People's Republic of China, 2Institute of Chemical Materials, China Academy of En...

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Autores principales:	Gao B, Wang J, Wang DJ, Zhu ZQ, Qiao ZQ, Yang GC, Nie FD
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/bb5f6faca18f4d3cbcac25a4e705927a
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spelling	oai:doaj.org-article:bb5f6faca18f4d3cbcac25a4e705927a2021-12-02T11:07:29ZA novel preparation method for drug nanocrystals and characterization by ultrasonic spray assisted electrostatic adsorption1176-91141178-2013https://doaj.org/article/bb5f6faca18f4d3cbcac25a4e705927a2013-10-01T00:00:00Zhttp://www.dovepress.com/a-novel-preparation-method-for-drug-nanocrystals-and-characterization--a14672https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Bing Gao,1–3 Jun Wang,2 Dunju Wang,1,2 Ziqiang Zhu,1,2 Zhiqiang Qiao,2 Guangcheng Yang,2 Fude Nie21School of Material Science and Engineering, Southwest University of Science and Technology, Mianyang, People's Republic of China, 2Institute of Chemical Materials, China Academy of Engineering Physics, Mianyang, Sichuan, People's Republic of China, 3Si Chuan Research Center of New Materials, Mianyang, People's Republic of ChinaPurpose: The purpose of this study was to develop a novel and continuous method for preparing a nanosized particle of drug crystals and to characterize its properties.Materials and methods: A new apparatus was introduced to crystallize nanosized drug crystals of amitriptyline hydrochloride as a model drug. The samples were prepared in the pure state by ultrasonic spray, and elaborated deposition was completed via electrostatic adsorption. Scanning electron microscopy, X-ray powder diffraction, and atomic force microscopy were used to characterize the size of the particles; this was subsequently followed by differential scanning calorimetry.Results and discussion: Nanoparticles of drug crystals were successfully prepared. The size of the drug crystals ranged from 20 nm to 400 nm; the particle size of amitriptyline hydrochloride was approximately 71 nm. The particles were spherical and rectangular in shape. Moreover, the melting point of the nanoparticles decreased from 198.2°C to 196.3°C when compared to raw particle crystals. Furthermore, the agglomeration effect was also attenuated as a result of electrostatic repulsion among each particle when absorbed, and depositing on the inner wall of the gathering unit occurred under the electrostatic effect.Conclusion: Ultrasonic spray-assisted electrostatic adsorption is a very effective and continuous method to produce drug nanocrystals. This method can be applied to poorly water-soluble drugs, and it can also be a very effective alternative for industrial production. Once the working parameters are given, drug nanocrystals will be produced continuously.Keywords: nanomedicine, amitriptyline hydrochloride, continuous, nanoparticlesGao BWang JWang DJZhu ZQQiao ZQYang GCNie FDDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss Issue 1, Pp 3927-3936 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Gao B Wang J Wang DJ Zhu ZQ Qiao ZQ Yang GC Nie FD A novel preparation method for drug nanocrystals and characterization by ultrasonic spray assisted electrostatic adsorption
description	Bing Gao,1–3 Jun Wang,2 Dunju Wang,1,2 Ziqiang Zhu,1,2 Zhiqiang Qiao,2 Guangcheng Yang,2 Fude Nie21School of Material Science and Engineering, Southwest University of Science and Technology, Mianyang, People's Republic of China, 2Institute of Chemical Materials, China Academy of Engineering Physics, Mianyang, Sichuan, People's Republic of China, 3Si Chuan Research Center of New Materials, Mianyang, People's Republic of ChinaPurpose: The purpose of this study was to develop a novel and continuous method for preparing a nanosized particle of drug crystals and to characterize its properties.Materials and methods: A new apparatus was introduced to crystallize nanosized drug crystals of amitriptyline hydrochloride as a model drug. The samples were prepared in the pure state by ultrasonic spray, and elaborated deposition was completed via electrostatic adsorption. Scanning electron microscopy, X-ray powder diffraction, and atomic force microscopy were used to characterize the size of the particles; this was subsequently followed by differential scanning calorimetry.Results and discussion: Nanoparticles of drug crystals were successfully prepared. The size of the drug crystals ranged from 20 nm to 400 nm; the particle size of amitriptyline hydrochloride was approximately 71 nm. The particles were spherical and rectangular in shape. Moreover, the melting point of the nanoparticles decreased from 198.2°C to 196.3°C when compared to raw particle crystals. Furthermore, the agglomeration effect was also attenuated as a result of electrostatic repulsion among each particle when absorbed, and depositing on the inner wall of the gathering unit occurred under the electrostatic effect.Conclusion: Ultrasonic spray-assisted electrostatic adsorption is a very effective and continuous method to produce drug nanocrystals. This method can be applied to poorly water-soluble drugs, and it can also be a very effective alternative for industrial production. Once the working parameters are given, drug nanocrystals will be produced continuously.Keywords: nanomedicine, amitriptyline hydrochloride, continuous, nanoparticles
format	article
author	Gao B Wang J Wang DJ Zhu ZQ Qiao ZQ Yang GC Nie FD
author_facet	Gao B Wang J Wang DJ Zhu ZQ Qiao ZQ Yang GC Nie FD
author_sort	Gao B
title	A novel preparation method for drug nanocrystals and characterization by ultrasonic spray assisted electrostatic adsorption
title_short	A novel preparation method for drug nanocrystals and characterization by ultrasonic spray assisted electrostatic adsorption
title_full	A novel preparation method for drug nanocrystals and characterization by ultrasonic spray assisted electrostatic adsorption
title_fullStr	A novel preparation method for drug nanocrystals and characterization by ultrasonic spray assisted electrostatic adsorption
title_full_unstemmed	A novel preparation method for drug nanocrystals and characterization by ultrasonic spray assisted electrostatic adsorption
title_sort	novel preparation method for drug nanocrystals and characterization by ultrasonic spray assisted electrostatic adsorption
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/bb5f6faca18f4d3cbcac25a4e705927a
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A novel preparation method for drug nanocrystals and characterization by ultrasonic spray assisted electrostatic adsorption

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