Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer

Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer

The relevance and underlying molecular mechanisms of epigenetic regulation in squamous cell carcinomas (SCC) await further characterization. Here, the authors show a transcriptional regulatory loop involving SREBF1, TP63 and KLF5 driving tumourigenesis in SCC through fatty acid, ERBB and mTOR pathwa...

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Autores principales: Li-Yan Li, Qian Yang, Yan-Yi Jiang, Wei Yang, Yuan Jiang, Xiang Li, Masaharu Hazawa, Bo Zhou, Guo-Wei Huang, Xiu-E Xu, Sigal Gery, Ying Zhang, Ling-Wen Ding, Allen S. Ho, Zachary S. Zumsteg, Ming-Rong Wang, Melissa J. Fullwood, Stephen J. Freedland, Stephen J. Meltzer, Li-Yan Xu, En-Min Li, H. Phillip Koeffler, De-Chen Lin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/bb5f76c06e2f4727bd8409644acda48f
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spelling oai:doaj.org-article:bb5f76c06e2f4727bd8409644acda48f2021-12-02T17:01:29ZInterplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer10.1038/s41467-021-24656-x2041-1723https://doaj.org/article/bb5f76c06e2f4727bd8409644acda48f2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24656-xhttps://doaj.org/toc/2041-1723The relevance and underlying molecular mechanisms of epigenetic regulation in squamous cell carcinomas (SCC) await further characterization. Here, the authors show a transcriptional regulatory loop involving SREBF1, TP63 and KLF5 driving tumourigenesis in SCC through fatty acid, ERBB and mTOR pathway regulation.Li-Yan LiQian YangYan-Yi JiangWei YangYuan JiangXiang LiMasaharu HazawaBo ZhouGuo-Wei HuangXiu-E XuSigal GeryYing ZhangLing-Wen DingAllen S. HoZachary S. ZumstegMing-Rong WangMelissa J. FullwoodStephen J. FreedlandStephen J. MeltzerLi-Yan XuEn-Min LiH. Phillip KoefflerDe-Chen LinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Li-Yan Li
Qian Yang
Yan-Yi Jiang
Wei Yang
Yuan Jiang
Xiang Li
Masaharu Hazawa
Bo Zhou
Guo-Wei Huang
Xiu-E Xu
Sigal Gery
Ying Zhang
Ling-Wen Ding
Allen S. Ho
Zachary S. Zumsteg
Ming-Rong Wang
Melissa J. Fullwood
Stephen J. Freedland
Stephen J. Meltzer
Li-Yan Xu
En-Min Li
H. Phillip Koeffler
De-Chen Lin
Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer
description The relevance and underlying molecular mechanisms of epigenetic regulation in squamous cell carcinomas (SCC) await further characterization. Here, the authors show a transcriptional regulatory loop involving SREBF1, TP63 and KLF5 driving tumourigenesis in SCC through fatty acid, ERBB and mTOR pathway regulation.
format article
author Li-Yan Li
Qian Yang
Yan-Yi Jiang
Wei Yang
Yuan Jiang
Xiang Li
Masaharu Hazawa
Bo Zhou
Guo-Wei Huang
Xiu-E Xu
Sigal Gery
Ying Zhang
Ling-Wen Ding
Allen S. Ho
Zachary S. Zumsteg
Ming-Rong Wang
Melissa J. Fullwood
Stephen J. Freedland
Stephen J. Meltzer
Li-Yan Xu
En-Min Li
H. Phillip Koeffler
De-Chen Lin
author_facet Li-Yan Li
Qian Yang
Yan-Yi Jiang
Wei Yang
Yuan Jiang
Xiang Li
Masaharu Hazawa
Bo Zhou
Guo-Wei Huang
Xiu-E Xu
Sigal Gery
Ying Zhang
Ling-Wen Ding
Allen S. Ho
Zachary S. Zumsteg
Ming-Rong Wang
Melissa J. Fullwood
Stephen J. Freedland
Stephen J. Meltzer
Li-Yan Xu
En-Min Li
H. Phillip Koeffler
De-Chen Lin
author_sort Li-Yan Li
title Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer
title_short Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer
title_full Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer
title_fullStr Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer
title_full_unstemmed Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer
title_sort interplay and cooperation between srebf1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/bb5f76c06e2f4727bd8409644acda48f
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