Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer

Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer

The relevance and underlying molecular mechanisms of epigenetic regulation in squamous cell carcinomas (SCC) await further characterization. Here, the authors show a transcriptional regulatory loop involving SREBF1, TP63 and KLF5 driving tumourigenesis in SCC through fatty acid, ERBB and mTOR pathwa...

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Autores principales: Li-Yan Li, Qian Yang, Yan-Yi Jiang, Wei Yang, Yuan Jiang, Xiang Li, Masaharu Hazawa, Bo Zhou, Guo-Wei Huang, Xiu-E Xu, Sigal Gery, Ying Zhang, Ling-Wen Ding, Allen S. Ho, Zachary S. Zumsteg, Ming-Rong Wang, Melissa J. Fullwood, Stephen J. Freedland, Stephen J. Meltzer, Li-Yan Xu, En-Min Li, H. Phillip Koeffler, De-Chen Lin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/bb5f76c06e2f4727bd8409644acda48f
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