The genetic architecture of human brainstem structures and their involvement in common brain disorders
The genetic architecture underlying brainstem regions and how this links to common brain disorders is not well understood. Here, the authors use MRI and GWAS data from 27,034 individuals to identify genetic and morphological brainstem features that influence common brain disorders.
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2020
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oai:doaj.org-article:bb60787933434b12ab5b236140b403a32021-12-02T16:28:52ZThe genetic architecture of human brainstem structures and their involvement in common brain disorders10.1038/s41467-020-17376-12041-1723https://doaj.org/article/bb60787933434b12ab5b236140b403a32020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17376-1https://doaj.org/toc/2041-1723The genetic architecture underlying brainstem regions and how this links to common brain disorders is not well understood. Here, the authors use MRI and GWAS data from 27,034 individuals to identify genetic and morphological brainstem features that influence common brain disorders.Torbjørn ElvsåshagenShahram BahramiDennis van der MeerIngrid AgartzDag AlnæsDeanna M. BarchRamona Baur-StreubelAlessandro BertolinoMona K. BeyerGiuseppe BlasiStefan BorgwardtBirgitte BoyeJan BuitelaarErlend BøenElisabeth Gulowsen CeliusSimon CervenkaAnnette ConzelmannDavid CoynelPasquale Di CarloSrdjan DjurovicSarah EisenacherThomas EspesethHelena Fatouros-BergmanLena FlycktBarbara FrankeOleksandr FreiBarbara GelaoHanne Flinstad HarboCatharina A. HartmanAsta HåbergDirk HeslenfeldPieter J. HoekstraEinar A. HøgestølRune JonassenErik G. JönssonKarolinska Schizophrenia Project (KaSP) consortiumPeter KirschIwona KłoszewskaTrine Vik LagerbergNils Inge LandrøStephanie Le HellardKlaus-Peter LeschLuigi A. MaglanocUlrik F. MaltPatrizia MecocciIngrid MelleAndreas Meyer-LindenbergTorgeir MobergetJan Egil NordvikLars NybergKevin S. O’ ConnellJaap OosterlaanMarco PapalinoAndreas PapassotiropoulosPaul PauliGiulio PergolaKarin PerssonDominique de QuervainAndreas ReifJaroslav RokickiDaan van RooijAlexey A. ShadrinAndré SchmidtEmanuel SchwarzGeir SelbækHilkka SoininenPiotr SowaVidar M. SteenMagda TsolakiBruno VellasLei WangEric WestmanGeorg C. ZieglerMathias ZinkOle A. AndreassenLars T. WestlyeTobias KaufmannNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
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Science Q Torbjørn Elvsåshagen Shahram Bahrami Dennis van der Meer Ingrid Agartz Dag Alnæs Deanna M. Barch Ramona Baur-Streubel Alessandro Bertolino Mona K. Beyer Giuseppe Blasi Stefan Borgwardt Birgitte Boye Jan Buitelaar Erlend Bøen Elisabeth Gulowsen Celius Simon Cervenka Annette Conzelmann David Coynel Pasquale Di Carlo Srdjan Djurovic Sarah Eisenacher Thomas Espeseth Helena Fatouros-Bergman Lena Flyckt Barbara Franke Oleksandr Frei Barbara Gelao Hanne Flinstad Harbo Catharina A. Hartman Asta Håberg Dirk Heslenfeld Pieter J. Hoekstra Einar A. Høgestøl Rune Jonassen Erik G. Jönsson Karolinska Schizophrenia Project (KaSP) consortium Peter Kirsch Iwona Kłoszewska Trine Vik Lagerberg Nils Inge Landrø Stephanie Le Hellard Klaus-Peter Lesch Luigi A. Maglanoc Ulrik F. Malt Patrizia Mecocci Ingrid Melle Andreas Meyer-Lindenberg Torgeir Moberget Jan Egil Nordvik Lars Nyberg Kevin S. O’ Connell Jaap Oosterlaan Marco Papalino Andreas Papassotiropoulos Paul Pauli Giulio Pergola Karin Persson Dominique de Quervain Andreas Reif Jaroslav Rokicki Daan van Rooij Alexey A. Shadrin André Schmidt Emanuel Schwarz Geir Selbæk Hilkka Soininen Piotr Sowa Vidar M. Steen Magda Tsolaki Bruno Vellas Lei Wang Eric Westman Georg C. Ziegler Mathias Zink Ole A. Andreassen Lars T. Westlye Tobias Kaufmann The genetic architecture of human brainstem structures and their involvement in common brain disorders |
description |
The genetic architecture underlying brainstem regions and how this links to common brain disorders is not well understood. Here, the authors use MRI and GWAS data from 27,034 individuals to identify genetic and morphological brainstem features that influence common brain disorders. |
format |
article |
author |
Torbjørn Elvsåshagen Shahram Bahrami Dennis van der Meer Ingrid Agartz Dag Alnæs Deanna M. Barch Ramona Baur-Streubel Alessandro Bertolino Mona K. Beyer Giuseppe Blasi Stefan Borgwardt Birgitte Boye Jan Buitelaar Erlend Bøen Elisabeth Gulowsen Celius Simon Cervenka Annette Conzelmann David Coynel Pasquale Di Carlo Srdjan Djurovic Sarah Eisenacher Thomas Espeseth Helena Fatouros-Bergman Lena Flyckt Barbara Franke Oleksandr Frei Barbara Gelao Hanne Flinstad Harbo Catharina A. Hartman Asta Håberg Dirk Heslenfeld Pieter J. Hoekstra Einar A. Høgestøl Rune Jonassen Erik G. Jönsson Karolinska Schizophrenia Project (KaSP) consortium Peter Kirsch Iwona Kłoszewska Trine Vik Lagerberg Nils Inge Landrø Stephanie Le Hellard Klaus-Peter Lesch Luigi A. Maglanoc Ulrik F. Malt Patrizia Mecocci Ingrid Melle Andreas Meyer-Lindenberg Torgeir Moberget Jan Egil Nordvik Lars Nyberg Kevin S. O’ Connell Jaap Oosterlaan Marco Papalino Andreas Papassotiropoulos Paul Pauli Giulio Pergola Karin Persson Dominique de Quervain Andreas Reif Jaroslav Rokicki Daan van Rooij Alexey A. Shadrin André Schmidt Emanuel Schwarz Geir Selbæk Hilkka Soininen Piotr Sowa Vidar M. Steen Magda Tsolaki Bruno Vellas Lei Wang Eric Westman Georg C. Ziegler Mathias Zink Ole A. Andreassen Lars T. Westlye Tobias Kaufmann |
author_facet |
Torbjørn Elvsåshagen Shahram Bahrami Dennis van der Meer Ingrid Agartz Dag Alnæs Deanna M. Barch Ramona Baur-Streubel Alessandro Bertolino Mona K. Beyer Giuseppe Blasi Stefan Borgwardt Birgitte Boye Jan Buitelaar Erlend Bøen Elisabeth Gulowsen Celius Simon Cervenka Annette Conzelmann David Coynel Pasquale Di Carlo Srdjan Djurovic Sarah Eisenacher Thomas Espeseth Helena Fatouros-Bergman Lena Flyckt Barbara Franke Oleksandr Frei Barbara Gelao Hanne Flinstad Harbo Catharina A. Hartman Asta Håberg Dirk Heslenfeld Pieter J. Hoekstra Einar A. Høgestøl Rune Jonassen Erik G. Jönsson Karolinska Schizophrenia Project (KaSP) consortium Peter Kirsch Iwona Kłoszewska Trine Vik Lagerberg Nils Inge Landrø Stephanie Le Hellard Klaus-Peter Lesch Luigi A. Maglanoc Ulrik F. Malt Patrizia Mecocci Ingrid Melle Andreas Meyer-Lindenberg Torgeir Moberget Jan Egil Nordvik Lars Nyberg Kevin S. O’ Connell Jaap Oosterlaan Marco Papalino Andreas Papassotiropoulos Paul Pauli Giulio Pergola Karin Persson Dominique de Quervain Andreas Reif Jaroslav Rokicki Daan van Rooij Alexey A. Shadrin André Schmidt Emanuel Schwarz Geir Selbæk Hilkka Soininen Piotr Sowa Vidar M. Steen Magda Tsolaki Bruno Vellas Lei Wang Eric Westman Georg C. Ziegler Mathias Zink Ole A. Andreassen Lars T. Westlye Tobias Kaufmann |
author_sort |
Torbjørn Elvsåshagen |
title |
The genetic architecture of human brainstem structures and their involvement in common brain disorders |
title_short |
The genetic architecture of human brainstem structures and their involvement in common brain disorders |
title_full |
The genetic architecture of human brainstem structures and their involvement in common brain disorders |
title_fullStr |
The genetic architecture of human brainstem structures and their involvement in common brain disorders |
title_full_unstemmed |
The genetic architecture of human brainstem structures and their involvement in common brain disorders |
title_sort |
genetic architecture of human brainstem structures and their involvement in common brain disorders |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/bb60787933434b12ab5b236140b403a3 |
work_keys_str_mv |
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