Aberrant Hematopoiesis and Morbidity in Extremely Preterm Infants With Intrauterine Growth Restriction

Background and Objective: Intrauterine growth restriction (IUGR) poses additional challenges in extremely low gestational age newborns (ELGANs). We assessed disturbed hematopoiesis and morbidities associated with this disorder.Methods: This single-center retrospective case–control study compared per...

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Autores principales:	Nora J. Reibel, Christof Dame, Christoph Bührer, Tobias Muehlbacher
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	anemia coagulation disorder neutropenia sepsis thrombocytopenia Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/bb608364c5eb44a79c28ce5eede2c845
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spelling	oai:doaj.org-article:bb608364c5eb44a79c28ce5eede2c8452021-11-12T06:58:50ZAberrant Hematopoiesis and Morbidity in Extremely Preterm Infants With Intrauterine Growth Restriction2296-236010.3389/fped.2021.728607https://doaj.org/article/bb608364c5eb44a79c28ce5eede2c8452021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fped.2021.728607/fullhttps://doaj.org/toc/2296-2360Background and Objective: Intrauterine growth restriction (IUGR) poses additional challenges in extremely low gestational age newborns (ELGANs). We assessed disturbed hematopoiesis and morbidities associated with this disorder.Methods: This single-center retrospective case–control study compared perinatal hematological profiles, major morbidities, and mortality of 49 infants (gestational age <28 weeks, birth weight ≤ 3rd percentile, and compromised placental function) and 98 infants (birth weight >10th percentile) matched for gestational age, year, and sex.Results: IUGR-ELGANs had significantly elevated nucleated red blood cells and lower neutrophil and platelet counts at birth and on the third day of life. During the first week of life, IUGR-ELGANs received more red blood cell, platelet, and plasma transfusions and were more intensively treated with antibiotics. Rates of infections acquired during the first week (59.2 vs. 17.3%, p < 0.001), severe bronchopulmonary dysplasia or death (42.9 vs. 17.3%, p < 0.01), and mortality (36.7 vs. 7.1%, p < 0.001) were markedly elevated in IUGR-ELGANs, but not of hemorrhages or other morbidities.Conclusions: IUGR-ELGANs have high rates of acquired infections during the first week of life and display severe pulmonary morbidity leading to bronchopulmonary dysplasia or death. The high rate of transfusions observed in these infants warrants further scrutiny.Nora J. ReibelChristof DameChristoph BührerTobias MuehlbacherTobias MuehlbacherFrontiers Media S.A.articleanemiacoagulation disorderneutropeniasepsisthrombocytopeniaPediatricsRJ1-570ENFrontiers in Pediatrics, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anemia coagulation disorder neutropenia sepsis thrombocytopenia Pediatrics RJ1-570
spellingShingle	anemia coagulation disorder neutropenia sepsis thrombocytopenia Pediatrics RJ1-570 Nora J. Reibel Christof Dame Christoph Bührer Tobias Muehlbacher Tobias Muehlbacher Aberrant Hematopoiesis and Morbidity in Extremely Preterm Infants With Intrauterine Growth Restriction
description	Background and Objective: Intrauterine growth restriction (IUGR) poses additional challenges in extremely low gestational age newborns (ELGANs). We assessed disturbed hematopoiesis and morbidities associated with this disorder.Methods: This single-center retrospective case–control study compared perinatal hematological profiles, major morbidities, and mortality of 49 infants (gestational age <28 weeks, birth weight ≤ 3rd percentile, and compromised placental function) and 98 infants (birth weight >10th percentile) matched for gestational age, year, and sex.Results: IUGR-ELGANs had significantly elevated nucleated red blood cells and lower neutrophil and platelet counts at birth and on the third day of life. During the first week of life, IUGR-ELGANs received more red blood cell, platelet, and plasma transfusions and were more intensively treated with antibiotics. Rates of infections acquired during the first week (59.2 vs. 17.3%, p < 0.001), severe bronchopulmonary dysplasia or death (42.9 vs. 17.3%, p < 0.01), and mortality (36.7 vs. 7.1%, p < 0.001) were markedly elevated in IUGR-ELGANs, but not of hemorrhages or other morbidities.Conclusions: IUGR-ELGANs have high rates of acquired infections during the first week of life and display severe pulmonary morbidity leading to bronchopulmonary dysplasia or death. The high rate of transfusions observed in these infants warrants further scrutiny.
format	article
author	Nora J. Reibel Christof Dame Christoph Bührer Tobias Muehlbacher Tobias Muehlbacher
author_facet	Nora J. Reibel Christof Dame Christoph Bührer Tobias Muehlbacher Tobias Muehlbacher
author_sort	Nora J. Reibel
title	Aberrant Hematopoiesis and Morbidity in Extremely Preterm Infants With Intrauterine Growth Restriction
title_short	Aberrant Hematopoiesis and Morbidity in Extremely Preterm Infants With Intrauterine Growth Restriction
title_full	Aberrant Hematopoiesis and Morbidity in Extremely Preterm Infants With Intrauterine Growth Restriction
title_fullStr	Aberrant Hematopoiesis and Morbidity in Extremely Preterm Infants With Intrauterine Growth Restriction
title_full_unstemmed	Aberrant Hematopoiesis and Morbidity in Extremely Preterm Infants With Intrauterine Growth Restriction
title_sort	aberrant hematopoiesis and morbidity in extremely preterm infants with intrauterine growth restriction
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/bb608364c5eb44a79c28ce5eede2c845
work_keys_str_mv	AT norajreibel aberranthematopoiesisandmorbidityinextremelypreterminfantswithintrauterinegrowthrestriction AT christofdame aberranthematopoiesisandmorbidityinextremelypreterminfantswithintrauterinegrowthrestriction AT christophbuhrer aberranthematopoiesisandmorbidityinextremelypreterminfantswithintrauterinegrowthrestriction AT tobiasmuehlbacher aberranthematopoiesisandmorbidityinextremelypreterminfantswithintrauterinegrowthrestriction AT tobiasmuehlbacher aberranthematopoiesisandmorbidityinextremelypreterminfantswithintrauterinegrowthrestriction
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Aberrant Hematopoiesis and Morbidity in Extremely Preterm Infants With Intrauterine Growth Restriction

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