Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine

FasR is a TetR-like transcriptional activator that plays a central role in sensing mycobacterial long-chain fatty acids and regulating lipid biosynthesis in Mycobacterium tuberculosis. Here authors present crystal structures of M. tuberculosis FasR in complex with acyl effector ligands and with DNA,...

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Autores principales:	Julia Lara, Lautaro Diacovich, Felipe Trajtenberg, Nicole Larrieux, Emilio L. Malchiodi, Marisa M. Fernández, Gabriela Gago, Hugo Gramajo, Alejandro Buschiazzo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bb60974c393341d483c45f151748dd51
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spelling	oai:doaj.org-article:bb60974c393341d483c45f151748dd512021-12-02T16:17:57ZMycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine10.1038/s41467-020-17504-x2041-1723https://doaj.org/article/bb60974c393341d483c45f151748dd512020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17504-xhttps://doaj.org/toc/2041-1723FasR is a TetR-like transcriptional activator that plays a central role in sensing mycobacterial long-chain fatty acids and regulating lipid biosynthesis in Mycobacterium tuberculosis. Here authors present crystal structures of M. tuberculosis FasR in complex with acyl effector ligands and with DNA, uncovering its molecular sensory and switching mechanisms.Julia LaraLautaro DiacovichFelipe TrajtenbergNicole LarrieuxEmilio L. MalchiodiMarisa M. FernándezGabriela GagoHugo GramajoAlejandro BuschiazzoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julia Lara Lautaro Diacovich Felipe Trajtenberg Nicole Larrieux Emilio L. Malchiodi Marisa M. Fernández Gabriela Gago Hugo Gramajo Alejandro Buschiazzo Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine
description	FasR is a TetR-like transcriptional activator that plays a central role in sensing mycobacterial long-chain fatty acids and regulating lipid biosynthesis in Mycobacterium tuberculosis. Here authors present crystal structures of M. tuberculosis FasR in complex with acyl effector ligands and with DNA, uncovering its molecular sensory and switching mechanisms.
format	article
author	Julia Lara Lautaro Diacovich Felipe Trajtenberg Nicole Larrieux Emilio L. Malchiodi Marisa M. Fernández Gabriela Gago Hugo Gramajo Alejandro Buschiazzo
author_facet	Julia Lara Lautaro Diacovich Felipe Trajtenberg Nicole Larrieux Emilio L. Malchiodi Marisa M. Fernández Gabriela Gago Hugo Gramajo Alejandro Buschiazzo
author_sort	Julia Lara
title	Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine
title_short	Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine
title_full	Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine
title_fullStr	Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine
title_full_unstemmed	Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine
title_sort	mycobacterium tuberculosis fasr senses long fatty acyl-coa through a tunnel and a hydrophobic transmission spine
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bb60974c393341d483c45f151748dd51
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Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine

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