Conformational heterogeneity in human interphase chromosome organization reconciles the FISH and Hi-C paradox

Studies comparing Hi-C and FISH data show that in some cases the distance between one pair of loci is paradoxically larger compared to another pair with a smaller value of the contact probability. Here the authors use a theory based on a Generalized Rouse Model for Chromosomes to resolve this parado...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Guang Shi, D. Thirumalai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bb61262f5b674913948e26cb5e50d456
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bb61262f5b674913948e26cb5e50d456
record_format	dspace
spelling	oai:doaj.org-article:bb61262f5b674913948e26cb5e50d4562021-12-02T14:35:31ZConformational heterogeneity in human interphase chromosome organization reconciles the FISH and Hi-C paradox10.1038/s41467-019-11897-02041-1723https://doaj.org/article/bb61262f5b674913948e26cb5e50d4562019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11897-0https://doaj.org/toc/2041-1723Studies comparing Hi-C and FISH data show that in some cases the distance between one pair of loci is paradoxically larger compared to another pair with a smaller value of the contact probability. Here the authors use a theory based on a Generalized Rouse Model for Chromosomes to resolve this paradox.Guang ShiD. ThirumalaiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guang Shi D. Thirumalai Conformational heterogeneity in human interphase chromosome organization reconciles the FISH and Hi-C paradox
description	Studies comparing Hi-C and FISH data show that in some cases the distance between one pair of loci is paradoxically larger compared to another pair with a smaller value of the contact probability. Here the authors use a theory based on a Generalized Rouse Model for Chromosomes to resolve this paradox.
format	article
author	Guang Shi D. Thirumalai
author_facet	Guang Shi D. Thirumalai
author_sort	Guang Shi
title	Conformational heterogeneity in human interphase chromosome organization reconciles the FISH and Hi-C paradox
title_short	Conformational heterogeneity in human interphase chromosome organization reconciles the FISH and Hi-C paradox
title_full	Conformational heterogeneity in human interphase chromosome organization reconciles the FISH and Hi-C paradox
title_fullStr	Conformational heterogeneity in human interphase chromosome organization reconciles the FISH and Hi-C paradox
title_full_unstemmed	Conformational heterogeneity in human interphase chromosome organization reconciles the FISH and Hi-C paradox
title_sort	conformational heterogeneity in human interphase chromosome organization reconciles the fish and hi-c paradox
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bb61262f5b674913948e26cb5e50d456
work_keys_str_mv	AT guangshi conformationalheterogeneityinhumaninterphasechromosomeorganizationreconcilesthefishandhicparadox AT dthirumalai conformationalheterogeneityinhumaninterphasechromosomeorganizationreconcilesthefishandhicparadox
_version_	1718391155265110016

Conformational heterogeneity in human interphase chromosome organization reconciles the FISH and Hi-C paradox

Ejemplares similares