Area 5 influences excitability within the primary motor cortex in humans.

In non-human primates, Brodmann's area 5 (BA 5) has direct connectivity with primary motor cortex (M1), is largely dedicated to the representation of the hand and may have evolved with the ability to perform skilled hand movement. Less is known about human BA 5 and its interaction with M1 neura...

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Autores principales:	Azra Premji, Navjot Rai, Aimee Nelson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bb63234c4bb045e8baa42c95f9611c77
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spelling	oai:doaj.org-article:bb63234c4bb045e8baa42c95f9611c772021-11-18T06:53:58ZArea 5 influences excitability within the primary motor cortex in humans.1932-620310.1371/journal.pone.0020023https://doaj.org/article/bb63234c4bb045e8baa42c95f9611c772011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21603571/?tool=EBIhttps://doaj.org/toc/1932-6203In non-human primates, Brodmann's area 5 (BA 5) has direct connectivity with primary motor cortex (M1), is largely dedicated to the representation of the hand and may have evolved with the ability to perform skilled hand movement. Less is known about human BA 5 and its interaction with M1 neural circuits related to hand control. The present study examines the influence of BA 5 on excitatory and inhibitory neural circuitry within M1 bilaterally before and after continuous (cTBS), intermittent (iTBS), and sham theta-burst stimulation (sham TBS) over left hemisphere BA 5. Using single and paired-pulse TMS, measurements of motor evoked potentials (MEPs), short interval intracortical inhibition (SICI), and intracortical facilitation (ICF) were quantified for the representation of the first dorsal interosseous muscle. Results indicate that cTBS over BA 5 influences M1 excitability such that MEP amplitudes are increased bilaterally for up to one hour. ITBS over BA 5 results in an increase in MEP amplitude contralateral to stimulation with a delayed onset that persists up to one hour. SICI and ICF were unaltered following TBS over BA 5. Similarly, F-wave amplitude and latency were unaltered following cTBS over BA 5. The data suggest that BA 5 alters M1 output directed to the hand by influencing corticospinal neurons and not interneurons that mediate SICI or ICF circuitry. Targeting BA 5 via cTBS and iTBS is a novel mechanism to powerfully modulate activity within M1 and may provide an avenue for investigating hand control in healthy populations and modifying impaired hand function in clinical populations.Azra PremjiNavjot RaiAimee NelsonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e20023 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Azra Premji Navjot Rai Aimee Nelson Area 5 influences excitability within the primary motor cortex in humans.
description	In non-human primates, Brodmann's area 5 (BA 5) has direct connectivity with primary motor cortex (M1), is largely dedicated to the representation of the hand and may have evolved with the ability to perform skilled hand movement. Less is known about human BA 5 and its interaction with M1 neural circuits related to hand control. The present study examines the influence of BA 5 on excitatory and inhibitory neural circuitry within M1 bilaterally before and after continuous (cTBS), intermittent (iTBS), and sham theta-burst stimulation (sham TBS) over left hemisphere BA 5. Using single and paired-pulse TMS, measurements of motor evoked potentials (MEPs), short interval intracortical inhibition (SICI), and intracortical facilitation (ICF) were quantified for the representation of the first dorsal interosseous muscle. Results indicate that cTBS over BA 5 influences M1 excitability such that MEP amplitudes are increased bilaterally for up to one hour. ITBS over BA 5 results in an increase in MEP amplitude contralateral to stimulation with a delayed onset that persists up to one hour. SICI and ICF were unaltered following TBS over BA 5. Similarly, F-wave amplitude and latency were unaltered following cTBS over BA 5. The data suggest that BA 5 alters M1 output directed to the hand by influencing corticospinal neurons and not interneurons that mediate SICI or ICF circuitry. Targeting BA 5 via cTBS and iTBS is a novel mechanism to powerfully modulate activity within M1 and may provide an avenue for investigating hand control in healthy populations and modifying impaired hand function in clinical populations.
format	article
author	Azra Premji Navjot Rai Aimee Nelson
author_facet	Azra Premji Navjot Rai Aimee Nelson
author_sort	Azra Premji
title	Area 5 influences excitability within the primary motor cortex in humans.
title_short	Area 5 influences excitability within the primary motor cortex in humans.
title_full	Area 5 influences excitability within the primary motor cortex in humans.
title_fullStr	Area 5 influences excitability within the primary motor cortex in humans.
title_full_unstemmed	Area 5 influences excitability within the primary motor cortex in humans.
title_sort	area 5 influences excitability within the primary motor cortex in humans.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/bb63234c4bb045e8baa42c95f9611c77
work_keys_str_mv	AT azrapremji area5influencesexcitabilitywithintheprimarymotorcortexinhumans AT navjotrai area5influencesexcitabilitywithintheprimarymotorcortexinhumans AT aimeenelson area5influencesexcitabilitywithintheprimarymotorcortexinhumans
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Area 5 influences excitability within the primary motor cortex in humans.

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