Structures of the human LONP1 protease reveal regulatory steps involved in protease activation

The human mitochondrial protease LONP1 is an AAA+ ATP-dependent quality control protease. Here, the authors present the cryo-EM structures of human LONP1 in three distinct states and provide insights into the mechanism and regulation of this important protease.

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Detalles Bibliográficos
Autores principales:	Mia Shin, Edmond R. Watson, Albert S. Song, Jeffrey T. Mindrebo, Scott J. Novick, Patrick R. Griffin, R. Luke Wiseman, Gabriel C. Lander
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bb66b8ea8165482a8ae94b393309ce0d
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spelling	oai:doaj.org-article:bb66b8ea8165482a8ae94b393309ce0d2021-12-02T14:49:22ZStructures of the human LONP1 protease reveal regulatory steps involved in protease activation10.1038/s41467-021-23495-02041-1723https://doaj.org/article/bb66b8ea8165482a8ae94b393309ce0d2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23495-0https://doaj.org/toc/2041-1723The human mitochondrial protease LONP1 is an AAA+ ATP-dependent quality control protease. Here, the authors present the cryo-EM structures of human LONP1 in three distinct states and provide insights into the mechanism and regulation of this important protease.Mia ShinEdmond R. WatsonAlbert S. SongJeffrey T. MindreboScott J. NovickPatrick R. GriffinR. Luke WisemanGabriel C. LanderNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mia Shin Edmond R. Watson Albert S. Song Jeffrey T. Mindrebo Scott J. Novick Patrick R. Griffin R. Luke Wiseman Gabriel C. Lander Structures of the human LONP1 protease reveal regulatory steps involved in protease activation
description	The human mitochondrial protease LONP1 is an AAA+ ATP-dependent quality control protease. Here, the authors present the cryo-EM structures of human LONP1 in three distinct states and provide insights into the mechanism and regulation of this important protease.
format	article
author	Mia Shin Edmond R. Watson Albert S. Song Jeffrey T. Mindrebo Scott J. Novick Patrick R. Griffin R. Luke Wiseman Gabriel C. Lander
author_facet	Mia Shin Edmond R. Watson Albert S. Song Jeffrey T. Mindrebo Scott J. Novick Patrick R. Griffin R. Luke Wiseman Gabriel C. Lander
author_sort	Mia Shin
title	Structures of the human LONP1 protease reveal regulatory steps involved in protease activation
title_short	Structures of the human LONP1 protease reveal regulatory steps involved in protease activation
title_full	Structures of the human LONP1 protease reveal regulatory steps involved in protease activation
title_fullStr	Structures of the human LONP1 protease reveal regulatory steps involved in protease activation
title_full_unstemmed	Structures of the human LONP1 protease reveal regulatory steps involved in protease activation
title_sort	structures of the human lonp1 protease reveal regulatory steps involved in protease activation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bb66b8ea8165482a8ae94b393309ce0d
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Structures of the human LONP1 protease reveal regulatory steps involved in protease activation

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