Structures of the human LONP1 protease reveal regulatory steps involved in protease activation

The human mitochondrial protease LONP1 is an AAA+ ATP-dependent quality control protease. Here, the authors present the cryo-EM structures of human LONP1 in three distinct states and provide insights into the mechanism and regulation of this important protease.

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Detalles Bibliográficos
Autores principales: Mia Shin, Edmond R. Watson, Albert S. Song, Jeffrey T. Mindrebo, Scott J. Novick, Patrick R. Griffin, R. Luke Wiseman, Gabriel C. Lander
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Q
Acceso en línea:https://doaj.org/article/bb66b8ea8165482a8ae94b393309ce0d
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