Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1

Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1

Altered monocyte responses and testosterone levels correlate, individually, with the pathogenesis of hepatic amebiasis in mice. Here the authors show that testosterone induces enhanced TNF/CXCL1 expression and stronger proinflammatory responses in both human and mouse monocytes to support an androge...

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Autores principales: Julie Sellau, Marie Groneberg, Helena Fehling, Thorsten Thye, Stefan Hoenow, Claudia Marggraff, Marie Weskamm, Charlotte Hansen, Stephanie Stanelle-Bertram, Svenja Kuehl, Jill Noll, Vincent Wolf, Nahla Galal Metwally, Sven Hendrik Hagen, Christoph Dorn, Julia Wernecke, Harald Ittrich, Egbert Tannich, Thomas Jacobs, Iris Bruchhaus, Marcus Altfeld, Hannelore Lotter
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/bb695d34b76a4b2c90047fbfce6a8c2a
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spelling oai:doaj.org-article:bb695d34b76a4b2c90047fbfce6a8c2a2021-12-02T15:23:10ZAndrogens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL110.1038/s41467-020-17260-y2041-1723https://doaj.org/article/bb695d34b76a4b2c90047fbfce6a8c2a2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17260-yhttps://doaj.org/toc/2041-1723Altered monocyte responses and testosterone levels correlate, individually, with the pathogenesis of hepatic amebiasis in mice. Here the authors show that testosterone induces enhanced TNF/CXCL1 expression and stronger proinflammatory responses in both human and mouse monocytes to support an androgen-monocyte axis of inflammation regulation.Julie SellauMarie GronebergHelena FehlingThorsten ThyeStefan HoenowClaudia MarggraffMarie WeskammCharlotte HansenStephanie Stanelle-BertramSvenja KuehlJill NollVincent WolfNahla Galal MetwallySven Hendrik HagenChristoph DornJulia WerneckeHarald IttrichEgbert TannichThomas JacobsIris BruchhausMarcus AltfeldHannelore LotterNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Julie Sellau
Marie Groneberg
Helena Fehling
Thorsten Thye
Stefan Hoenow
Claudia Marggraff
Marie Weskamm
Charlotte Hansen
Stephanie Stanelle-Bertram
Svenja Kuehl
Jill Noll
Vincent Wolf
Nahla Galal Metwally
Sven Hendrik Hagen
Christoph Dorn
Julia Wernecke
Harald Ittrich
Egbert Tannich
Thomas Jacobs
Iris Bruchhaus
Marcus Altfeld
Hannelore Lotter
Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1
description Altered monocyte responses and testosterone levels correlate, individually, with the pathogenesis of hepatic amebiasis in mice. Here the authors show that testosterone induces enhanced TNF/CXCL1 expression and stronger proinflammatory responses in both human and mouse monocytes to support an androgen-monocyte axis of inflammation regulation.
format article
author Julie Sellau
Marie Groneberg
Helena Fehling
Thorsten Thye
Stefan Hoenow
Claudia Marggraff
Marie Weskamm
Charlotte Hansen
Stephanie Stanelle-Bertram
Svenja Kuehl
Jill Noll
Vincent Wolf
Nahla Galal Metwally
Sven Hendrik Hagen
Christoph Dorn
Julia Wernecke
Harald Ittrich
Egbert Tannich
Thomas Jacobs
Iris Bruchhaus
Marcus Altfeld
Hannelore Lotter
author_facet Julie Sellau
Marie Groneberg
Helena Fehling
Thorsten Thye
Stefan Hoenow
Claudia Marggraff
Marie Weskamm
Charlotte Hansen
Stephanie Stanelle-Bertram
Svenja Kuehl
Jill Noll
Vincent Wolf
Nahla Galal Metwally
Sven Hendrik Hagen
Christoph Dorn
Julia Wernecke
Harald Ittrich
Egbert Tannich
Thomas Jacobs
Iris Bruchhaus
Marcus Altfeld
Hannelore Lotter
author_sort Julie Sellau
title Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1
title_short Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1
title_full Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1
title_fullStr Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1
title_full_unstemmed Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1
title_sort androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor cxcl1
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/bb695d34b76a4b2c90047fbfce6a8c2a
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