Symptoms and syndromes associated with SARS-CoV-2 infection and severity in pregnant women from two community cohorts

Abstract We tested whether pregnant and non-pregnant women differ in COVID-19 symptom profile and severity, and we extended previous investigations on hospitalized pregnant women to those who did not require hospitalization. Two female community-based cohorts (18–44 years) provided longitudinal (sma...

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Autores principales:	Erika Molteni, Christina M. Astley, Wenjie Ma, Carole H. Sudre, Laura A. Magee, Benjamin Murray, Tove Fall, Maria F. Gomez, Neli Tsereteli, Paul W. Franks, John S. Brownstein, Richard Davies, Jonathan Wolf, Tim D. Spector, Sebastien Ourselin, Claire J. Steves, Andrew T. Chan, Marc Modat
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bb6b0e3a04684681ba9637d440467b56
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spelling	oai:doaj.org-article:bb6b0e3a04684681ba9637d440467b562021-12-02T16:36:04ZSymptoms and syndromes associated with SARS-CoV-2 infection and severity in pregnant women from two community cohorts10.1038/s41598-021-86452-32045-2322https://doaj.org/article/bb6b0e3a04684681ba9637d440467b562021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86452-3https://doaj.org/toc/2045-2322Abstract We tested whether pregnant and non-pregnant women differ in COVID-19 symptom profile and severity, and we extended previous investigations on hospitalized pregnant women to those who did not require hospitalization. Two female community-based cohorts (18–44 years) provided longitudinal (smartphone application, N = 1,170,315, n = 79 pregnant tested positive) and cross-sectional (web-based survey, N = 1,344,966, n = 134 pregnant tested positive) data, prospectively collected through self-participatory citizen surveillance in UK, Sweden and USA. Pregnant and non-pregnant were compared for frequencies of events, including SARS-CoV-2 testing, symptoms and hospitalization rates. Multivariable regression was used to investigate symptoms severity and comorbidity effects. Pregnant and non-pregnant women positive for SARS-CoV-2 infection were not different in syndromic severity, except for gastrointestinal symptoms. Pregnant were more likely to have received testing, despite reporting fewer symptoms. Pre-existing lung disease was most closely associated with syndromic severity in pregnant hospitalized. Heart and kidney diseases and diabetes increased risk. The most frequent symptoms among non-hospitalized women were anosmia [63% pregnant, 92% non-pregnant] and headache [72%, 62%]. Cardiopulmonary symptoms, including persistent cough [80%] and chest pain [73%], were more frequent among pregnant who were hospitalized. Consistent with observations in non-pregnant populations, lung disease and diabetes were associated with increased risk of more severe SARS-CoV-2 infection during pregnancy.Erika MolteniChristina M. AstleyWenjie MaCarole H. SudreLaura A. MageeBenjamin MurrayTove FallMaria F. GomezNeli TsereteliPaul W. FranksJohn S. BrownsteinRichard DaviesJonathan WolfTim D. SpectorSebastien OurselinClaire J. StevesAndrew T. ChanMarc ModatNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Erika Molteni Christina M. Astley Wenjie Ma Carole H. Sudre Laura A. Magee Benjamin Murray Tove Fall Maria F. Gomez Neli Tsereteli Paul W. Franks John S. Brownstein Richard Davies Jonathan Wolf Tim D. Spector Sebastien Ourselin Claire J. Steves Andrew T. Chan Marc Modat Symptoms and syndromes associated with SARS-CoV-2 infection and severity in pregnant women from two community cohorts
description	Abstract We tested whether pregnant and non-pregnant women differ in COVID-19 symptom profile and severity, and we extended previous investigations on hospitalized pregnant women to those who did not require hospitalization. Two female community-based cohorts (18–44 years) provided longitudinal (smartphone application, N = 1,170,315, n = 79 pregnant tested positive) and cross-sectional (web-based survey, N = 1,344,966, n = 134 pregnant tested positive) data, prospectively collected through self-participatory citizen surveillance in UK, Sweden and USA. Pregnant and non-pregnant were compared for frequencies of events, including SARS-CoV-2 testing, symptoms and hospitalization rates. Multivariable regression was used to investigate symptoms severity and comorbidity effects. Pregnant and non-pregnant women positive for SARS-CoV-2 infection were not different in syndromic severity, except for gastrointestinal symptoms. Pregnant were more likely to have received testing, despite reporting fewer symptoms. Pre-existing lung disease was most closely associated with syndromic severity in pregnant hospitalized. Heart and kidney diseases and diabetes increased risk. The most frequent symptoms among non-hospitalized women were anosmia [63% pregnant, 92% non-pregnant] and headache [72%, 62%]. Cardiopulmonary symptoms, including persistent cough [80%] and chest pain [73%], were more frequent among pregnant who were hospitalized. Consistent with observations in non-pregnant populations, lung disease and diabetes were associated with increased risk of more severe SARS-CoV-2 infection during pregnancy.
format	article
author	Erika Molteni Christina M. Astley Wenjie Ma Carole H. Sudre Laura A. Magee Benjamin Murray Tove Fall Maria F. Gomez Neli Tsereteli Paul W. Franks John S. Brownstein Richard Davies Jonathan Wolf Tim D. Spector Sebastien Ourselin Claire J. Steves Andrew T. Chan Marc Modat
author_facet	Erika Molteni Christina M. Astley Wenjie Ma Carole H. Sudre Laura A. Magee Benjamin Murray Tove Fall Maria F. Gomez Neli Tsereteli Paul W. Franks John S. Brownstein Richard Davies Jonathan Wolf Tim D. Spector Sebastien Ourselin Claire J. Steves Andrew T. Chan Marc Modat
author_sort	Erika Molteni
title	Symptoms and syndromes associated with SARS-CoV-2 infection and severity in pregnant women from two community cohorts
title_short	Symptoms and syndromes associated with SARS-CoV-2 infection and severity in pregnant women from two community cohorts
title_full	Symptoms and syndromes associated with SARS-CoV-2 infection and severity in pregnant women from two community cohorts
title_fullStr	Symptoms and syndromes associated with SARS-CoV-2 infection and severity in pregnant women from two community cohorts
title_full_unstemmed	Symptoms and syndromes associated with SARS-CoV-2 infection and severity in pregnant women from two community cohorts
title_sort	symptoms and syndromes associated with sars-cov-2 infection and severity in pregnant women from two community cohorts
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bb6b0e3a04684681ba9637d440467b56
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Symptoms and syndromes associated with SARS-CoV-2 infection and severity in pregnant women from two community cohorts

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