The complete genome and phenome of a community-acquired Acinetobacter baumannii.

Many sequenced strains of Acinetobacter baumannii are established nosocomial pathogens capable of resistance to multiple antimicrobials. Community-acquired A. baumannii in contrast, comprise a minor proportion of all A. baumannii infections and are highly susceptible to antimicrobial treatment. Howe...

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Autores principales:	Daniel N Farrugia, Liam D H Elbourne, Karl A Hassan, Bart A Eijkelkamp, Sasha G Tetu, Melissa H Brown, Bhumika S Shah, Anton Y Peleg, Bridget C Mabbutt, Ian T Paulsen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bb6e8722dced48aea22252f64b00c0ff
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spelling	oai:doaj.org-article:bb6e8722dced48aea22252f64b00c0ff2021-11-18T07:52:58ZThe complete genome and phenome of a community-acquired Acinetobacter baumannii.1932-620310.1371/journal.pone.0058628https://doaj.org/article/bb6e8722dced48aea22252f64b00c0ff2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23527001/?tool=EBIhttps://doaj.org/toc/1932-6203Many sequenced strains of Acinetobacter baumannii are established nosocomial pathogens capable of resistance to multiple antimicrobials. Community-acquired A. baumannii in contrast, comprise a minor proportion of all A. baumannii infections and are highly susceptible to antimicrobial treatment. However, these infections also present acute clinical manifestations associated with high reported rates of mortality. We report the complete 3.70 Mbp genome of A. baumannii D1279779, previously isolated from the bacteraemic infection of an Indigenous Australian; this strain represents the first community-acquired A. baumannii to be sequenced. Comparative analysis of currently published A. baumannii genomes identified twenty-four accessory gene clusters present in D1279779. These accessory elements were predicted to encode a range of functions including polysaccharide biosynthesis, type I DNA restriction-modification, and the metabolism of novel carbonaceous and nitrogenous compounds. Conversely, twenty genomic regions present in previously sequenced A. baumannii strains were absent in D1279779, including gene clusters involved in the catabolism of 4-hydroxybenzoate and glucarate, and the A. baumannii antibiotic resistance island, known to bestow resistance to multiple antimicrobials in nosocomial strains. Phenomic analysis utilising the Biolog Phenotype Microarray system indicated that A. baumannii D1279779 can utilise a broader range of carbon and nitrogen sources than international clone I and clone II nosocomial isolates. However, D1279779 was more sensitive to antimicrobial compounds, particularly beta-lactams, tetracyclines and sulphonamides. The combined genomic and phenomic analyses have provided insight into the features distinguishing A. baumannii isolated from community-acquired and nosocomial infections.Daniel N FarrugiaLiam D H ElbourneKarl A HassanBart A EijkelkampSasha G TetuMelissa H BrownBhumika S ShahAnton Y PelegBridget C MabbuttIan T PaulsenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e58628 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel N Farrugia Liam D H Elbourne Karl A Hassan Bart A Eijkelkamp Sasha G Tetu Melissa H Brown Bhumika S Shah Anton Y Peleg Bridget C Mabbutt Ian T Paulsen The complete genome and phenome of a community-acquired Acinetobacter baumannii.
description	Many sequenced strains of Acinetobacter baumannii are established nosocomial pathogens capable of resistance to multiple antimicrobials. Community-acquired A. baumannii in contrast, comprise a minor proportion of all A. baumannii infections and are highly susceptible to antimicrobial treatment. However, these infections also present acute clinical manifestations associated with high reported rates of mortality. We report the complete 3.70 Mbp genome of A. baumannii D1279779, previously isolated from the bacteraemic infection of an Indigenous Australian; this strain represents the first community-acquired A. baumannii to be sequenced. Comparative analysis of currently published A. baumannii genomes identified twenty-four accessory gene clusters present in D1279779. These accessory elements were predicted to encode a range of functions including polysaccharide biosynthesis, type I DNA restriction-modification, and the metabolism of novel carbonaceous and nitrogenous compounds. Conversely, twenty genomic regions present in previously sequenced A. baumannii strains were absent in D1279779, including gene clusters involved in the catabolism of 4-hydroxybenzoate and glucarate, and the A. baumannii antibiotic resistance island, known to bestow resistance to multiple antimicrobials in nosocomial strains. Phenomic analysis utilising the Biolog Phenotype Microarray system indicated that A. baumannii D1279779 can utilise a broader range of carbon and nitrogen sources than international clone I and clone II nosocomial isolates. However, D1279779 was more sensitive to antimicrobial compounds, particularly beta-lactams, tetracyclines and sulphonamides. The combined genomic and phenomic analyses have provided insight into the features distinguishing A. baumannii isolated from community-acquired and nosocomial infections.
format	article
author	Daniel N Farrugia Liam D H Elbourne Karl A Hassan Bart A Eijkelkamp Sasha G Tetu Melissa H Brown Bhumika S Shah Anton Y Peleg Bridget C Mabbutt Ian T Paulsen
author_facet	Daniel N Farrugia Liam D H Elbourne Karl A Hassan Bart A Eijkelkamp Sasha G Tetu Melissa H Brown Bhumika S Shah Anton Y Peleg Bridget C Mabbutt Ian T Paulsen
author_sort	Daniel N Farrugia
title	The complete genome and phenome of a community-acquired Acinetobacter baumannii.
title_short	The complete genome and phenome of a community-acquired Acinetobacter baumannii.
title_full	The complete genome and phenome of a community-acquired Acinetobacter baumannii.
title_fullStr	The complete genome and phenome of a community-acquired Acinetobacter baumannii.
title_full_unstemmed	The complete genome and phenome of a community-acquired Acinetobacter baumannii.
title_sort	complete genome and phenome of a community-acquired acinetobacter baumannii.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/bb6e8722dced48aea22252f64b00c0ff
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The complete genome and phenome of a community-acquired Acinetobacter baumannii.

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