Smoking, urinary cotinine levels and incidence of visual impairment

Abstract The longitudinal relationship between smoking status and risk of developing visual impairment (VI) remains unclear. We examined the relationship of smoking status and urinary cotinine level, an objective measure of smoking, with incidence of VI. This cohort study included 279,069 individual...

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Autores principales:	So Young Han, Yoosoo Chang, Hocheol Shin, Chul Young Choi, Seungho Ryu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bb705f3ac35d492b8f9c7a259dc1e968
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spelling	oai:doaj.org-article:bb705f3ac35d492b8f9c7a259dc1e9682021-12-02T14:12:08ZSmoking, urinary cotinine levels and incidence of visual impairment10.1038/s41598-020-79865-z2045-2322https://doaj.org/article/bb705f3ac35d492b8f9c7a259dc1e9682021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79865-zhttps://doaj.org/toc/2045-2322Abstract The longitudinal relationship between smoking status and risk of developing visual impairment (VI) remains unclear. We examined the relationship of smoking status and urinary cotinine level, an objective measure of smoking, with incidence of VI. This cohort study included 279,069 individuals free of VI who were followed for up to 8.8 years (median 4.8 years). VI was defined as when bilateral visual acuity was worse than 0.5 (cutoffs of 0.3 Logarithm of the Minimum Angle of Resolution). During 1,324,429.8 person-years of follow-up, 7852 participants developed new-onset bilateral VI. Self-reported current smoking status was associated with increased risk of developing VI in both men and women, with a stronger association in women (P for interaction = 0.01). Multivariable adjusted hazard ratios (95% confidence intervals) for incident VI comparing current smokers to never-smokers were 1.14 (1.04–1.25) in men and 1.52 (1.28–1.80) in women. Urinary cotinine levels of ≥ 100 ng/ml were significantly associated with increased risk of incident VI, and these associations remained when introducing changes in urinary cotinine and other confounders during follow-up as time-varying covariates. Cigarette smoking assessed based on self-report and urinary cotinine level was associated with increased incidence of VI. Our findings identify smoking as an independent risk factor for VI.So Young HanYoosoo ChangHocheol ShinChul Young ChoiSeungho RyuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q So Young Han Yoosoo Chang Hocheol Shin Chul Young Choi Seungho Ryu Smoking, urinary cotinine levels and incidence of visual impairment
description	Abstract The longitudinal relationship between smoking status and risk of developing visual impairment (VI) remains unclear. We examined the relationship of smoking status and urinary cotinine level, an objective measure of smoking, with incidence of VI. This cohort study included 279,069 individuals free of VI who were followed for up to 8.8 years (median 4.8 years). VI was defined as when bilateral visual acuity was worse than 0.5 (cutoffs of 0.3 Logarithm of the Minimum Angle of Resolution). During 1,324,429.8 person-years of follow-up, 7852 participants developed new-onset bilateral VI. Self-reported current smoking status was associated with increased risk of developing VI in both men and women, with a stronger association in women (P for interaction = 0.01). Multivariable adjusted hazard ratios (95% confidence intervals) for incident VI comparing current smokers to never-smokers were 1.14 (1.04–1.25) in men and 1.52 (1.28–1.80) in women. Urinary cotinine levels of ≥ 100 ng/ml were significantly associated with increased risk of incident VI, and these associations remained when introducing changes in urinary cotinine and other confounders during follow-up as time-varying covariates. Cigarette smoking assessed based on self-report and urinary cotinine level was associated with increased incidence of VI. Our findings identify smoking as an independent risk factor for VI.
format	article
author	So Young Han Yoosoo Chang Hocheol Shin Chul Young Choi Seungho Ryu
author_facet	So Young Han Yoosoo Chang Hocheol Shin Chul Young Choi Seungho Ryu
author_sort	So Young Han
title	Smoking, urinary cotinine levels and incidence of visual impairment
title_short	Smoking, urinary cotinine levels and incidence of visual impairment
title_full	Smoking, urinary cotinine levels and incidence of visual impairment
title_fullStr	Smoking, urinary cotinine levels and incidence of visual impairment
title_full_unstemmed	Smoking, urinary cotinine levels and incidence of visual impairment
title_sort	smoking, urinary cotinine levels and incidence of visual impairment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bb705f3ac35d492b8f9c7a259dc1e968
work_keys_str_mv	AT soyounghan smokingurinarycotininelevelsandincidenceofvisualimpairment AT yoosoochang smokingurinarycotininelevelsandincidenceofvisualimpairment AT hocheolshin smokingurinarycotininelevelsandincidenceofvisualimpairment AT chulyoungchoi smokingurinarycotininelevelsandincidenceofvisualimpairment AT seunghoryu smokingurinarycotininelevelsandincidenceofvisualimpairment
_version_	1718391807131254784

Smoking, urinary cotinine levels and incidence of visual impairment

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