DYNAMICS OF CYTOKINE LEVELS IN PATIENTS WITH MYOCARDIAL INFARCTION AFTER URGENT PERCUTANEOUS CORONARY INTERVENTION

Abstract. The study included 154 cases of acute myocardial infarction (MI) with ST segment elevation. Cytokine levels were determined in all the patients at days +1 and +10 after hospital admission, using quantitative ELISA assays. On day +1, a more that 2-fold increase was revealed for TNFα and IL-...

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Autores principales:	E. A. Schmidt, S. A. Berns, O. L. Barbarash, E. S. Yukhno, D. S. Zykova, A. V. Osokina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	cytokines myocardial infarction nonspecific inflammation biomarkers Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/bb78556acab24ae497e633145ae13707
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spelling	oai:doaj.org-article:bb78556acab24ae497e633145ae137072021-11-18T08:03:41ZDYNAMICS OF CYTOKINE LEVELS IN PATIENTS WITH MYOCARDIAL INFARCTION AFTER URGENT PERCUTANEOUS CORONARY INTERVENTION1563-06252313-741X10.15789/1563-0625-2012-4-5-359-364https://doaj.org/article/bb78556acab24ae497e633145ae137072014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/524https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The study included 154 cases of acute myocardial infarction (MI) with ST segment elevation. Cytokine levels were determined in all the patients at days +1 and +10 after hospital admission, using quantitative ELISA assays. On day +1, a more that 2-fold increase was revealed for TNFα and IL-1α, as compared with healthy individuals. On day +10, we found a more than twofold increase in TNFα and IL-8 in blood plasma, whereas IL-1α and IL-10 levels became significantly reduced by the day +10, as compared to median values at day +1 of the study. Moreover, dynamics of the cytokines was compared between clinical subgroups of MI patients classified by gender, age, or presence of early complications. It was noted that the patients with complicated course of myocardial infarction exhibited high levels of IL-1α both on the day 1, and on day +10 of the disease. In female patients, the levels of both IL-8 and IL-10 were not significantly changed by day +10 after MI. Among younger patients (<56 years old), a significant reduction of IL-10 plasma levels was shown by day +10 of myocardial infarction, as compared with absence of significant IL-10 dynamics in older patients.E. A. SchmidtS. A. BernsO. L. BarbarashE. S. YukhnoD. S. ZykovaA. V. OsokinaSPb RAACIarticlecytokinesmyocardial infarctionnonspecific inflammationbiomarkersImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 4-5, Pp 359-364 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokines myocardial infarction nonspecific inflammation biomarkers Immunologic diseases. Allergy RC581-607
spellingShingle	cytokines myocardial infarction nonspecific inflammation biomarkers Immunologic diseases. Allergy RC581-607 E. A. Schmidt S. A. Berns O. L. Barbarash E. S. Yukhno D. S. Zykova A. V. Osokina DYNAMICS OF CYTOKINE LEVELS IN PATIENTS WITH MYOCARDIAL INFARCTION AFTER URGENT PERCUTANEOUS CORONARY INTERVENTION
description	Abstract. The study included 154 cases of acute myocardial infarction (MI) with ST segment elevation. Cytokine levels were determined in all the patients at days +1 and +10 after hospital admission, using quantitative ELISA assays. On day +1, a more that 2-fold increase was revealed for TNFα and IL-1α, as compared with healthy individuals. On day +10, we found a more than twofold increase in TNFα and IL-8 in blood plasma, whereas IL-1α and IL-10 levels became significantly reduced by the day +10, as compared to median values at day +1 of the study. Moreover, dynamics of the cytokines was compared between clinical subgroups of MI patients classified by gender, age, or presence of early complications. It was noted that the patients with complicated course of myocardial infarction exhibited high levels of IL-1α both on the day 1, and on day +10 of the disease. In female patients, the levels of both IL-8 and IL-10 were not significantly changed by day +10 after MI. Among younger patients (<56 years old), a significant reduction of IL-10 plasma levels was shown by day +10 of myocardial infarction, as compared with absence of significant IL-10 dynamics in older patients.
format	article
author	E. A. Schmidt S. A. Berns O. L. Barbarash E. S. Yukhno D. S. Zykova A. V. Osokina
author_facet	E. A. Schmidt S. A. Berns O. L. Barbarash E. S. Yukhno D. S. Zykova A. V. Osokina
author_sort	E. A. Schmidt
title	DYNAMICS OF CYTOKINE LEVELS IN PATIENTS WITH MYOCARDIAL INFARCTION AFTER URGENT PERCUTANEOUS CORONARY INTERVENTION
title_short	DYNAMICS OF CYTOKINE LEVELS IN PATIENTS WITH MYOCARDIAL INFARCTION AFTER URGENT PERCUTANEOUS CORONARY INTERVENTION
title_full	DYNAMICS OF CYTOKINE LEVELS IN PATIENTS WITH MYOCARDIAL INFARCTION AFTER URGENT PERCUTANEOUS CORONARY INTERVENTION
title_fullStr	DYNAMICS OF CYTOKINE LEVELS IN PATIENTS WITH MYOCARDIAL INFARCTION AFTER URGENT PERCUTANEOUS CORONARY INTERVENTION
title_full_unstemmed	DYNAMICS OF CYTOKINE LEVELS IN PATIENTS WITH MYOCARDIAL INFARCTION AFTER URGENT PERCUTANEOUS CORONARY INTERVENTION
title_sort	dynamics of cytokine levels in patients with myocardial infarction after urgent percutaneous coronary intervention
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/bb78556acab24ae497e633145ae13707
work_keys_str_mv	AT easchmidt dynamicsofcytokinelevelsinpatientswithmyocardialinfarctionafterurgentpercutaneouscoronaryintervention AT saberns dynamicsofcytokinelevelsinpatientswithmyocardialinfarctionafterurgentpercutaneouscoronaryintervention AT olbarbarash dynamicsofcytokinelevelsinpatientswithmyocardialinfarctionafterurgentpercutaneouscoronaryintervention AT esyukhno dynamicsofcytokinelevelsinpatientswithmyocardialinfarctionafterurgentpercutaneouscoronaryintervention AT dszykova dynamicsofcytokinelevelsinpatientswithmyocardialinfarctionafterurgentpercutaneouscoronaryintervention AT avosokina dynamicsofcytokinelevelsinpatientswithmyocardialinfarctionafterurgentpercutaneouscoronaryintervention
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DYNAMICS OF CYTOKINE LEVELS IN PATIENTS WITH MYOCARDIAL INFARCTION AFTER URGENT PERCUTANEOUS CORONARY INTERVENTION

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