B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma
The regulation of tumor inflammation is incompletely understood and the role of B cells is unclear. Here, the authors show that a specific subtype of B cells is induced in melanoma and required to recruit T lymphocytes and elicit inflammation.
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Nature Portfolio
2019
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| Acceso en línea: | https://doaj.org/article/bb7a13c9ab124182a8b518e472ddcec1 |
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oai:doaj.org-article:bb7a13c9ab124182a8b518e472ddcec12021-12-02T17:31:52ZB cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma10.1038/s41467-019-12160-22041-1723https://doaj.org/article/bb7a13c9ab124182a8b518e472ddcec12019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12160-2https://doaj.org/toc/2041-1723The regulation of tumor inflammation is incompletely understood and the role of B cells is unclear. Here, the authors show that a specific subtype of B cells is induced in melanoma and required to recruit T lymphocytes and elicit inflammation.Johannes GrissWolfgang BauerChristine WagnerMartin SimonMinyi ChenKatharina Grabmeier-PfistershammerMargarita Maurer-GranofszkyFlorian RokaThomas PenzChristoph BockGao ZhangMeenhard HerlynKatharina GlatzHeinz LäubliKirsten D. MertzPeter PetzelbauerThomas WiesnerMarkus HartlWinfried F. PicklRajasekharan SomasundaramPeter SteinbergerStephan N. WagnerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Johannes Griss Wolfgang Bauer Christine Wagner Martin Simon Minyi Chen Katharina Grabmeier-Pfistershammer Margarita Maurer-Granofszky Florian Roka Thomas Penz Christoph Bock Gao Zhang Meenhard Herlyn Katharina Glatz Heinz Läubli Kirsten D. Mertz Peter Petzelbauer Thomas Wiesner Markus Hartl Winfried F. Pickl Rajasekharan Somasundaram Peter Steinberger Stephan N. Wagner B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma |
| description |
The regulation of tumor inflammation is incompletely understood and the role of B cells is unclear. Here, the authors show that a specific subtype of B cells is induced in melanoma and required to recruit T lymphocytes and elicit inflammation. |
| format |
article |
| author |
Johannes Griss Wolfgang Bauer Christine Wagner Martin Simon Minyi Chen Katharina Grabmeier-Pfistershammer Margarita Maurer-Granofszky Florian Roka Thomas Penz Christoph Bock Gao Zhang Meenhard Herlyn Katharina Glatz Heinz Läubli Kirsten D. Mertz Peter Petzelbauer Thomas Wiesner Markus Hartl Winfried F. Pickl Rajasekharan Somasundaram Peter Steinberger Stephan N. Wagner |
| author_facet |
Johannes Griss Wolfgang Bauer Christine Wagner Martin Simon Minyi Chen Katharina Grabmeier-Pfistershammer Margarita Maurer-Granofszky Florian Roka Thomas Penz Christoph Bock Gao Zhang Meenhard Herlyn Katharina Glatz Heinz Läubli Kirsten D. Mertz Peter Petzelbauer Thomas Wiesner Markus Hartl Winfried F. Pickl Rajasekharan Somasundaram Peter Steinberger Stephan N. Wagner |
| author_sort |
Johannes Griss |
| title |
B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma |
| title_short |
B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma |
| title_full |
B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma |
| title_fullStr |
B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma |
| title_full_unstemmed |
B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma |
| title_sort |
b cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/bb7a13c9ab124182a8b518e472ddcec1 |
| work_keys_str_mv |
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| _version_ |
1718380452770742272 |