CARBONIC ANHYDRASE IN <i>Plasmodium falciparum</i>: A USEFUL TARGET FOR ANTIMALARIAL DRUG DESIGNING AND MALARIA blocking TRANSMISSION COMPOUNDS

Carbonic anhydrase is a metalloenzyme that catalyzes the reversible conversion of CO2 to bicarbonate, an essential metabolic component used by the malaria parasites for de novo synthesis of pyrimidines and the exflagelation of gametocytes inside the mosquito vector. Carbonic anhydrase is involved in...

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Autores principales:	Carlos D. AGUDELO R., María CORENA-Mcleod, Sara M. ROBLEDO R.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2010
Materias:	Plasmodium falciparum carbonic anhydrase bicarbonate carbon dioxide. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/bb7e9c1d9d344705a053a743e83e5356
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spelling	oai:doaj.org-article:bb7e9c1d9d344705a053a743e83e53562021-11-19T04:14:36ZCARBONIC ANHYDRASE IN <i>Plasmodium falciparum</i>: A USEFUL TARGET FOR ANTIMALARIAL DRUG DESIGNING AND MALARIA blocking TRANSMISSION COMPOUNDS0121-40042145-2660https://doaj.org/article/bb7e9c1d9d344705a053a743e83e53562010-03-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/4981https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660Carbonic anhydrase is a metalloenzyme that catalyzes the reversible conversion of CO2 to bicarbonate, an essential metabolic component used by the malaria parasites for de novo synthesis of pyrimidines and the exflagelation of gametocytes inside the mosquito vector. Carbonic anhydrase is involved in the transport of bicarbonate. This enzyme participates in transport of bicarbonate inside and outside the cells to avoid an imbalance in the system CO2/HCO3- and alteration of pH in the interior of the cell as well as in the intercellular space. Therefore, inhibition of this enzyme either in the parasite or the insect vector, could lead to a decrease in replication and to the detriment and/or death of the parasite. Given the importance of carbonic anhydrase in the metabolism, development and survival of Plasmodium, it could be postulated that carbonic anhydrase inhibitors are both a therapeutic and a blocking transmission alternative. Previous studies have demonstrated the in vitro anti-Plasmodium activity of some inhibitors. However, it is necessary to determine their effectiveness to confirm its usefulness in the treatment or blocking malaria transmission and the mechanism by which these inhibitors are able to affect the development of the parasite in the mosquito vector. In this paper we present a review about the role of carbonic anhydrase in Plasmodium spp and using some specific inhibitors as a strategy for malaria treatment and transmission blocking strategy. Articles published in the past 59 years identified from bibliographic database (PubMed and ScienceDirect) and papers collected by the authors were included.Carlos D. AGUDELO R.María CORENA-McleodSara M. ROBLEDO R.Universidad de AntioquiaarticlePlasmodium falciparumcarbonic anhydrasebicarbonatecarbon dioxide.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 17, Iss 1 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Plasmodium falciparum carbonic anhydrase bicarbonate carbon dioxide. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Plasmodium falciparum carbonic anhydrase bicarbonate carbon dioxide. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Carlos D. AGUDELO R. María CORENA-Mcleod Sara M. ROBLEDO R. CARBONIC ANHYDRASE IN <i>Plasmodium falciparum</i>: A USEFUL TARGET FOR ANTIMALARIAL DRUG DESIGNING AND MALARIA blocking TRANSMISSION COMPOUNDS
description	Carbonic anhydrase is a metalloenzyme that catalyzes the reversible conversion of CO2 to bicarbonate, an essential metabolic component used by the malaria parasites for de novo synthesis of pyrimidines and the exflagelation of gametocytes inside the mosquito vector. Carbonic anhydrase is involved in the transport of bicarbonate. This enzyme participates in transport of bicarbonate inside and outside the cells to avoid an imbalance in the system CO2/HCO3- and alteration of pH in the interior of the cell as well as in the intercellular space. Therefore, inhibition of this enzyme either in the parasite or the insect vector, could lead to a decrease in replication and to the detriment and/or death of the parasite. Given the importance of carbonic anhydrase in the metabolism, development and survival of Plasmodium, it could be postulated that carbonic anhydrase inhibitors are both a therapeutic and a blocking transmission alternative. Previous studies have demonstrated the in vitro anti-Plasmodium activity of some inhibitors. However, it is necessary to determine their effectiveness to confirm its usefulness in the treatment or blocking malaria transmission and the mechanism by which these inhibitors are able to affect the development of the parasite in the mosquito vector. In this paper we present a review about the role of carbonic anhydrase in Plasmodium spp and using some specific inhibitors as a strategy for malaria treatment and transmission blocking strategy. Articles published in the past 59 years identified from bibliographic database (PubMed and ScienceDirect) and papers collected by the authors were included.
format	article
author	Carlos D. AGUDELO R. María CORENA-Mcleod Sara M. ROBLEDO R.
author_facet	Carlos D. AGUDELO R. María CORENA-Mcleod Sara M. ROBLEDO R.
author_sort	Carlos D. AGUDELO R.
title	CARBONIC ANHYDRASE IN <i>Plasmodium falciparum</i>: A USEFUL TARGET FOR ANTIMALARIAL DRUG DESIGNING AND MALARIA blocking TRANSMISSION COMPOUNDS
title_short	CARBONIC ANHYDRASE IN <i>Plasmodium falciparum</i>: A USEFUL TARGET FOR ANTIMALARIAL DRUG DESIGNING AND MALARIA blocking TRANSMISSION COMPOUNDS
title_full	CARBONIC ANHYDRASE IN <i>Plasmodium falciparum</i>: A USEFUL TARGET FOR ANTIMALARIAL DRUG DESIGNING AND MALARIA blocking TRANSMISSION COMPOUNDS
title_fullStr	CARBONIC ANHYDRASE IN <i>Plasmodium falciparum</i>: A USEFUL TARGET FOR ANTIMALARIAL DRUG DESIGNING AND MALARIA blocking TRANSMISSION COMPOUNDS
title_full_unstemmed	CARBONIC ANHYDRASE IN <i>Plasmodium falciparum</i>: A USEFUL TARGET FOR ANTIMALARIAL DRUG DESIGNING AND MALARIA blocking TRANSMISSION COMPOUNDS
title_sort	carbonic anhydrase in <i>plasmodium falciparum</i>: a useful target for antimalarial drug designing and malaria blocking transmission compounds
publisher	Universidad de Antioquia
publishDate	2010
url	https://doaj.org/article/bb7e9c1d9d344705a053a743e83e5356
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CARBONIC ANHYDRASE IN <i>Plasmodium falciparum</i>: A USEFUL TARGET FOR ANTIMALARIAL DRUG DESIGNING AND MALARIA blocking TRANSMISSION COMPOUNDS

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