The increasing incidence and prevalence of hypereosinophilic syndrome in the United Kingdom

Abstract Introduction Data on the burden of hypereosinophilic syndrome (HES) are limited. This study investigated the incidence and prevalence of HES using real‐world data from patients in the United Kingdom. Methods Primary care data from the Clinical Practice Research Datalink were analyzed. The p...

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Autores principales:	Gema Requena, John Logie, Daniel C. Gibbons, Jonathan Steinfeld, Melissa K. Van Dyke
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	hypereosinophilic syndrome incidence prevalence United Kingdom Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/bb846459b2d146bca141be52aa8e96d5
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spelling	oai:doaj.org-article:bb846459b2d146bca141be52aa8e96d52021-11-12T19:57:15ZThe increasing incidence and prevalence of hypereosinophilic syndrome in the United Kingdom2050-452710.1002/iid3.495https://doaj.org/article/bb846459b2d146bca141be52aa8e96d52021-12-01T00:00:00Zhttps://doi.org/10.1002/iid3.495https://doaj.org/toc/2050-4527Abstract Introduction Data on the burden of hypereosinophilic syndrome (HES) are limited. This study investigated the incidence and prevalence of HES using real‐world data from patients in the United Kingdom. Methods Primary care data from the Clinical Practice Research Datalink were analyzed. The patients of interest were identified using medical codes specific for HES. Annual incidence rates and prevalence were estimated for the years 2010–2018 (inclusive) using patients observed for a minimum period of one year. Results Between 2010 and 2018, 93 patients were identified with HES. During the study period the incidence of HES ranged from less than 0.04, 95% confidence interval (CI) (0.01–0.07) to 0.17, 95% CI (0.10–0.26) per 100,000 person‐years and the prevalence ranged from 0.15, 95% CI (0.10–0.25) to 0.89, 95% CI (0.74–1.09) cases per 100,000 persons. Sensitivity analyses varying the minimum observation period required to identify HES patients gave similar results. Conclusion These results provide estimates of the burden of HES in the United Kingdom and indicate that whilst HES is a very rare disease, there is evidence that is increasingly being recorded in UK primary care.Gema RequenaJohn LogieDaniel C. GibbonsJonathan SteinfeldMelissa K. Van DykeWileyarticlehypereosinophilic syndromeincidenceprevalenceUnited KingdomImmunologic diseases. AllergyRC581-607ENImmunity, Inflammation and Disease, Vol 9, Iss 4, Pp 1447-1451 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hypereosinophilic syndrome incidence prevalence United Kingdom Immunologic diseases. Allergy RC581-607
spellingShingle	hypereosinophilic syndrome incidence prevalence United Kingdom Immunologic diseases. Allergy RC581-607 Gema Requena John Logie Daniel C. Gibbons Jonathan Steinfeld Melissa K. Van Dyke The increasing incidence and prevalence of hypereosinophilic syndrome in the United Kingdom
description	Abstract Introduction Data on the burden of hypereosinophilic syndrome (HES) are limited. This study investigated the incidence and prevalence of HES using real‐world data from patients in the United Kingdom. Methods Primary care data from the Clinical Practice Research Datalink were analyzed. The patients of interest were identified using medical codes specific for HES. Annual incidence rates and prevalence were estimated for the years 2010–2018 (inclusive) using patients observed for a minimum period of one year. Results Between 2010 and 2018, 93 patients were identified with HES. During the study period the incidence of HES ranged from less than 0.04, 95% confidence interval (CI) (0.01–0.07) to 0.17, 95% CI (0.10–0.26) per 100,000 person‐years and the prevalence ranged from 0.15, 95% CI (0.10–0.25) to 0.89, 95% CI (0.74–1.09) cases per 100,000 persons. Sensitivity analyses varying the minimum observation period required to identify HES patients gave similar results. Conclusion These results provide estimates of the burden of HES in the United Kingdom and indicate that whilst HES is a very rare disease, there is evidence that is increasingly being recorded in UK primary care.
format	article
author	Gema Requena John Logie Daniel C. Gibbons Jonathan Steinfeld Melissa K. Van Dyke
author_facet	Gema Requena John Logie Daniel C. Gibbons Jonathan Steinfeld Melissa K. Van Dyke
author_sort	Gema Requena
title	The increasing incidence and prevalence of hypereosinophilic syndrome in the United Kingdom
title_short	The increasing incidence and prevalence of hypereosinophilic syndrome in the United Kingdom
title_full	The increasing incidence and prevalence of hypereosinophilic syndrome in the United Kingdom
title_fullStr	The increasing incidence and prevalence of hypereosinophilic syndrome in the United Kingdom
title_full_unstemmed	The increasing incidence and prevalence of hypereosinophilic syndrome in the United Kingdom
title_sort	increasing incidence and prevalence of hypereosinophilic syndrome in the united kingdom
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/bb846459b2d146bca141be52aa8e96d5
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The increasing incidence and prevalence of hypereosinophilic syndrome in the United Kingdom

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