Global chromatin conformation differences in the Drosophila dosage compensated chromosome X

In Drosophila, dosage compensation involves a twofold transcriptional upregulation of the single male chromosome X. Here the authors show that global conformational differences are specifically present in the male X chromosome and detectable using Hi-C data, indicating that dosage compensation affec...

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Auteurs principaux:	Koustav Pal, Mattia Forcato, Daniel Jost, Thomas Sexton, Cédric Vaillant, Elisa Salviato, Emilia Maria Cristina Mazza, Enrico Lugli, Giacomo Cavalli, Francesco Ferrari
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/bb84ecd207e648109c6d2daba488a3b7
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spelling	oai:doaj.org-article:bb84ecd207e648109c6d2daba488a3b72021-12-02T15:35:49ZGlobal chromatin conformation differences in the Drosophila dosage compensated chromosome X10.1038/s41467-019-13350-82041-1723https://doaj.org/article/bb84ecd207e648109c6d2daba488a3b72019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13350-8https://doaj.org/toc/2041-1723In Drosophila, dosage compensation involves a twofold transcriptional upregulation of the single male chromosome X. Here the authors show that global conformational differences are specifically present in the male X chromosome and detectable using Hi-C data, indicating that dosage compensation affects global chromosome structure.Koustav PalMattia ForcatoDaniel JostThomas SextonCédric VaillantElisa SalviatoEmilia Maria Cristina MazzaEnrico LugliGiacomo CavalliFrancesco FerrariNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Koustav Pal Mattia Forcato Daniel Jost Thomas Sexton Cédric Vaillant Elisa Salviato Emilia Maria Cristina Mazza Enrico Lugli Giacomo Cavalli Francesco Ferrari Global chromatin conformation differences in the Drosophila dosage compensated chromosome X
description	In Drosophila, dosage compensation involves a twofold transcriptional upregulation of the single male chromosome X. Here the authors show that global conformational differences are specifically present in the male X chromosome and detectable using Hi-C data, indicating that dosage compensation affects global chromosome structure.
format	article
author	Koustav Pal Mattia Forcato Daniel Jost Thomas Sexton Cédric Vaillant Elisa Salviato Emilia Maria Cristina Mazza Enrico Lugli Giacomo Cavalli Francesco Ferrari
author_facet	Koustav Pal Mattia Forcato Daniel Jost Thomas Sexton Cédric Vaillant Elisa Salviato Emilia Maria Cristina Mazza Enrico Lugli Giacomo Cavalli Francesco Ferrari
author_sort	Koustav Pal
title	Global chromatin conformation differences in the Drosophila dosage compensated chromosome X
title_short	Global chromatin conformation differences in the Drosophila dosage compensated chromosome X
title_full	Global chromatin conformation differences in the Drosophila dosage compensated chromosome X
title_fullStr	Global chromatin conformation differences in the Drosophila dosage compensated chromosome X
title_full_unstemmed	Global chromatin conformation differences in the Drosophila dosage compensated chromosome X
title_sort	global chromatin conformation differences in the drosophila dosage compensated chromosome x
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bb84ecd207e648109c6d2daba488a3b7
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_version_	1718386435494510592

Global chromatin conformation differences in the Drosophila dosage compensated chromosome X

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