A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics

Abstract In recent years, spherical nanoparticles has been studied extensively on biomedical applications including bioimaging and biosensing, diagnostics and theranostics, but the effect of the shape of nanoparticles has received little attention. In the present study, we designed three different s...

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Autores principales:	Yating Zhao, Yu Wang, Fu Ran, Yu Cui, Chang Liu, Qinfu Zhao, Yikun Gao, Da Wang, Siling Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bb85b3ff08be436a81b7746d56425687
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spelling	oai:doaj.org-article:bb85b3ff08be436a81b7746d564256872021-12-02T11:50:57ZA comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics10.1038/s41598-017-03834-22045-2322https://doaj.org/article/bb85b3ff08be436a81b7746d564256872017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03834-2https://doaj.org/toc/2045-2322Abstract In recent years, spherical nanoparticles has been studied extensively on biomedical applications including bioimaging and biosensing, diagnostics and theranostics, but the effect of the shape of nanoparticles has received little attention. In the present study, we designed three different shaped fluorescent mesoporous silica nanoparticles (MSNs), long rod nanoparticles (NLR), short rod nanoparticles (NSR), and spherical nanoparticles (NS) to systematically examine their behavior in vivo after oral administration. The results of the ex vivo optical imaging study in mice indicated that rod nanoparticles had a longer residence time in the gastrointestinal compared with spherical nanoparticles. The in vivo biodistribution showed that all the orally administered MSNs were mainly taken up by the liver, and kidney. NLR had a great capacity to overcoming rapid clearance by the RES and exhibited a longer circulation in the blood than NSR and NS. During renal excretion, the spherical nanoparticles were cleared faster than rod nanoparticles. In addition, it was also found that MSNs can be degraded in vivo and NSR were degraded faster than NLR and NS probably owing to their higher specific surface area. The pharmacokinetic results demonstrated that nifedipine(NI)-loaded NLR had a higher bioavailability than NI-loaded NSR and NS.Yating ZhaoYu WangFu RanYu CuiChang LiuQinfu ZhaoYikun GaoDa WangSiling WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yating Zhao Yu Wang Fu Ran Yu Cui Chang Liu Qinfu Zhao Yikun Gao Da Wang Siling Wang A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics
description	Abstract In recent years, spherical nanoparticles has been studied extensively on biomedical applications including bioimaging and biosensing, diagnostics and theranostics, but the effect of the shape of nanoparticles has received little attention. In the present study, we designed three different shaped fluorescent mesoporous silica nanoparticles (MSNs), long rod nanoparticles (NLR), short rod nanoparticles (NSR), and spherical nanoparticles (NS) to systematically examine their behavior in vivo after oral administration. The results of the ex vivo optical imaging study in mice indicated that rod nanoparticles had a longer residence time in the gastrointestinal compared with spherical nanoparticles. The in vivo biodistribution showed that all the orally administered MSNs were mainly taken up by the liver, and kidney. NLR had a great capacity to overcoming rapid clearance by the RES and exhibited a longer circulation in the blood than NSR and NS. During renal excretion, the spherical nanoparticles were cleared faster than rod nanoparticles. In addition, it was also found that MSNs can be degraded in vivo and NSR were degraded faster than NLR and NS probably owing to their higher specific surface area. The pharmacokinetic results demonstrated that nifedipine(NI)-loaded NLR had a higher bioavailability than NI-loaded NSR and NS.
format	article
author	Yating Zhao Yu Wang Fu Ran Yu Cui Chang Liu Qinfu Zhao Yikun Gao Da Wang Siling Wang
author_facet	Yating Zhao Yu Wang Fu Ran Yu Cui Chang Liu Qinfu Zhao Yikun Gao Da Wang Siling Wang
author_sort	Yating Zhao
title	A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics
title_short	A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics
title_full	A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics
title_fullStr	A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics
title_full_unstemmed	A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics
title_sort	comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bb85b3ff08be436a81b7746d56425687
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A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics

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