The Need for Alternatives to Liver Biopsies: Non-Invasive Analytics and Diagnostics

James Neuberger,1 Owen Cain2 1Liver Unit, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK; 2Department of Cellular Pathology, Queen Elizabeth Hospital, Birmingham, B15 2TH, UKCorrespondence: James NeubergerLiver Unit, Queen Elizabeth Hospital, Birmingham, B15 2TH, UKTel +44 7827299254Email jamesne...

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Autores principales:	Neuberger J, Cain O
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	imaging liquid biopsies multiple liver pathology unknown pathology non-invasive tests Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/bb8a9963ddbe457297203f874ccf216e
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spelling	oai:doaj.org-article:bb8a9963ddbe457297203f874ccf216e2021-12-02T17:44:01ZThe Need for Alternatives to Liver Biopsies: Non-Invasive Analytics and Diagnostics1179-1535https://doaj.org/article/bb8a9963ddbe457297203f874ccf216e2021-06-01T00:00:00Zhttps://www.dovepress.com/the-need-for-alternatives-to-liver-biopsies-non-invasive-analytics-and-peer-reviewed-fulltext-article-HMERhttps://doaj.org/toc/1179-1535James Neuberger,1 Owen Cain2 1Liver Unit, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK; 2Department of Cellular Pathology, Queen Elizabeth Hospital, Birmingham, B15 2TH, UKCorrespondence: James NeubergerLiver Unit, Queen Elizabeth Hospital, Birmingham, B15 2TH, UKTel +44 7827299254Email jamesneuberger@hotmail.co.ukAbstract: Histology remains essential for the diagnosis and management of many disorders affecting the liver. However, the biopsy procedure itself is associated with a low risk of harm to the patient and cost to the health services; samples may not be adequate and are subject to sampling variation. Furthermore, interpretation often depends on the skill of the pathologist. Increasingly, new techniques are becoming available that are altering the indications for liver biopsy. Many diseases of the liver can be diagnosed and managed using serological and radiological techniques; the degree of fibrosis and fat can often be assessed by serological or imaging techniques and the nature of space occupying lesions defined by serology, imaging and use of liquid biopsy. However, these techniques, too, are subject to limitations: sensitivity and specificity is not always adequate for diagnosis or management; some techniques are expensive and often also require expert interpretation. Although there may be less need for liver biopsy today, histology remains the gold standard as well as an essential tool for the diagnosis and management of many conditions, especially where there are multiple pathologies, or where a diagnosis cannot or has not been made by alternative approaches. Until less invasive techniques become more reliable and accessible, liver histology will remain a key investigation.Keywords: imaging, liquid biopsies, multiple liver pathology, unknown pathology, non-invasive testsNeuberger JCain ODove Medical Pressarticleimagingliquid biopsiesmultiple liver pathologyunknown pathologynon-invasive testsDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol Volume 13, Pp 59-69 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	imaging liquid biopsies multiple liver pathology unknown pathology non-invasive tests Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	imaging liquid biopsies multiple liver pathology unknown pathology non-invasive tests Diseases of the digestive system. Gastroenterology RC799-869 Neuberger J Cain O The Need for Alternatives to Liver Biopsies: Non-Invasive Analytics and Diagnostics
description	James Neuberger,1 Owen Cain2 1Liver Unit, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK; 2Department of Cellular Pathology, Queen Elizabeth Hospital, Birmingham, B15 2TH, UKCorrespondence: James NeubergerLiver Unit, Queen Elizabeth Hospital, Birmingham, B15 2TH, UKTel +44 7827299254Email jamesneuberger@hotmail.co.ukAbstract: Histology remains essential for the diagnosis and management of many disorders affecting the liver. However, the biopsy procedure itself is associated with a low risk of harm to the patient and cost to the health services; samples may not be adequate and are subject to sampling variation. Furthermore, interpretation often depends on the skill of the pathologist. Increasingly, new techniques are becoming available that are altering the indications for liver biopsy. Many diseases of the liver can be diagnosed and managed using serological and radiological techniques; the degree of fibrosis and fat can often be assessed by serological or imaging techniques and the nature of space occupying lesions defined by serology, imaging and use of liquid biopsy. However, these techniques, too, are subject to limitations: sensitivity and specificity is not always adequate for diagnosis or management; some techniques are expensive and often also require expert interpretation. Although there may be less need for liver biopsy today, histology remains the gold standard as well as an essential tool for the diagnosis and management of many conditions, especially where there are multiple pathologies, or where a diagnosis cannot or has not been made by alternative approaches. Until less invasive techniques become more reliable and accessible, liver histology will remain a key investigation.Keywords: imaging, liquid biopsies, multiple liver pathology, unknown pathology, non-invasive tests
format	article
author	Neuberger J Cain O
author_facet	Neuberger J Cain O
author_sort	Neuberger J
title	The Need for Alternatives to Liver Biopsies: Non-Invasive Analytics and Diagnostics
title_short	The Need for Alternatives to Liver Biopsies: Non-Invasive Analytics and Diagnostics
title_full	The Need for Alternatives to Liver Biopsies: Non-Invasive Analytics and Diagnostics
title_fullStr	The Need for Alternatives to Liver Biopsies: Non-Invasive Analytics and Diagnostics
title_full_unstemmed	The Need for Alternatives to Liver Biopsies: Non-Invasive Analytics and Diagnostics
title_sort	need for alternatives to liver biopsies: non-invasive analytics and diagnostics
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/bb8a9963ddbe457297203f874ccf216e
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The Need for Alternatives to Liver Biopsies: Non-Invasive Analytics and Diagnostics

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