Investigation of gold nanoparticle effects in brachytherapy by an electron emitter ophthalmic plaque

S Hashemi,1 MR Aghamiri,1 M Kahani,1 R Jaberi21Radiation Medicine Engineering Department, Shahid Beheshti University, Tehran, Iran; 2Cancer Institute, Imam Khomeini Hospital, Tehran, IranBackground: During decades, all improvements and developments in radiation therapy technologies have been focused...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hashemi S, Aghamiri MR, Kahani M, Jaberi R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Gold-Nano particles Dose Enhancement Electron brachytherapy Ru-106 eye plaque Monte Carlo simulation Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/bb8b1e077ecb4a1a8aa31cceee6e95e7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bb8b1e077ecb4a1a8aa31cceee6e95e7
record_format	dspace
spelling	oai:doaj.org-article:bb8b1e077ecb4a1a8aa31cceee6e95e72021-12-02T04:09:27ZInvestigation of gold nanoparticle effects in brachytherapy by an electron emitter ophthalmic plaque1178-2013https://doaj.org/article/bb8b1e077ecb4a1a8aa31cceee6e95e72019-06-01T00:00:00Zhttps://www.dovepress.com/investigation-of-gold-nanoparticle-effects-in-brachytherapy-by-an-elec-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013S Hashemi,1 MR Aghamiri,1 M Kahani,1 R Jaberi21Radiation Medicine Engineering Department, Shahid Beheshti University, Tehran, Iran; 2Cancer Institute, Imam Khomeini Hospital, Tehran, IranBackground: During decades, all improvements and developments in radiation therapy technologies have been focused on its main goal: maximize the dose in the tumor and minimize it in surrounding normal tissues. Recently, scientists have some approaches to nanoparticles, especially gold nanoparticles (GNPs), for dose localization.Purpose: Herein, the effect of GNPs in combination with electron brachytherapy in a model of eye tumor has been investigated.Materials and methods: Monte Carlo simulation was utilized and a complete anatomical model of the eye, a tumor with 5 mm thick, and a type of Ruthenium-106 beta emitter ophthalmic plaque were simulated. Simulation results have been validated by a Plexiglas eye phantom and film dosimetry, experimentally.Results: The results showed using GNPs causes the dose amplification in 2 mm from the plaque surface which the higher concentration has the higher enhancement. At more distances, Dose Enhancement Factors (DEFs) have the negative amounts, so that total delivered dose to the tumor has decreased with increasing of Au concentrations and the dose of organ at risk like sclera has increased.Conclusion: Therefore, using of GNPs along with a 106,Ru/106,Rh ocular plaque, as an electron emitter source, is a good choice only for superficial lesions, and it is not recommended for deeper tumors due to the parameters of radiation treatment and delivered dose to the tissues.Keywords: gold-nanoparticles, dose enhancement, electron brachytherapy, Ru-106 eye plaque, Monte Carlo simulationHashemi SAghamiri MRKahani MJaberi RDove Medical PressarticleGold-Nano particlesDose EnhancementElectron brachytherapyRu-106 eye plaqueMonte Carlo simulationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 4157-4165 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gold-Nano particles Dose Enhancement Electron brachytherapy Ru-106 eye plaque Monte Carlo simulation Medicine (General) R5-920
spellingShingle	Gold-Nano particles Dose Enhancement Electron brachytherapy Ru-106 eye plaque Monte Carlo simulation Medicine (General) R5-920 Hashemi S Aghamiri MR Kahani M Jaberi R Investigation of gold nanoparticle effects in brachytherapy by an electron emitter ophthalmic plaque
description	S Hashemi,1 MR Aghamiri,1 M Kahani,1 R Jaberi21Radiation Medicine Engineering Department, Shahid Beheshti University, Tehran, Iran; 2Cancer Institute, Imam Khomeini Hospital, Tehran, IranBackground: During decades, all improvements and developments in radiation therapy technologies have been focused on its main goal: maximize the dose in the tumor and minimize it in surrounding normal tissues. Recently, scientists have some approaches to nanoparticles, especially gold nanoparticles (GNPs), for dose localization.Purpose: Herein, the effect of GNPs in combination with electron brachytherapy in a model of eye tumor has been investigated.Materials and methods: Monte Carlo simulation was utilized and a complete anatomical model of the eye, a tumor with 5 mm thick, and a type of Ruthenium-106 beta emitter ophthalmic plaque were simulated. Simulation results have been validated by a Plexiglas eye phantom and film dosimetry, experimentally.Results: The results showed using GNPs causes the dose amplification in 2 mm from the plaque surface which the higher concentration has the higher enhancement. At more distances, Dose Enhancement Factors (DEFs) have the negative amounts, so that total delivered dose to the tumor has decreased with increasing of Au concentrations and the dose of organ at risk like sclera has increased.Conclusion: Therefore, using of GNPs along with a 106,Ru/106,Rh ocular plaque, as an electron emitter source, is a good choice only for superficial lesions, and it is not recommended for deeper tumors due to the parameters of radiation treatment and delivered dose to the tissues.Keywords: gold-nanoparticles, dose enhancement, electron brachytherapy, Ru-106 eye plaque, Monte Carlo simulation
format	article
author	Hashemi S Aghamiri MR Kahani M Jaberi R
author_facet	Hashemi S Aghamiri MR Kahani M Jaberi R
author_sort	Hashemi S
title	Investigation of gold nanoparticle effects in brachytherapy by an electron emitter ophthalmic plaque
title_short	Investigation of gold nanoparticle effects in brachytherapy by an electron emitter ophthalmic plaque
title_full	Investigation of gold nanoparticle effects in brachytherapy by an electron emitter ophthalmic plaque
title_fullStr	Investigation of gold nanoparticle effects in brachytherapy by an electron emitter ophthalmic plaque
title_full_unstemmed	Investigation of gold nanoparticle effects in brachytherapy by an electron emitter ophthalmic plaque
title_sort	investigation of gold nanoparticle effects in brachytherapy by an electron emitter ophthalmic plaque
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/bb8b1e077ecb4a1a8aa31cceee6e95e7
work_keys_str_mv	AT hashemis investigationofgoldnanoparticleeffectsinbrachytherapybyanelectronemitterophthalmicplaque AT aghamirimr investigationofgoldnanoparticleeffectsinbrachytherapybyanelectronemitterophthalmicplaque AT kahanim investigationofgoldnanoparticleeffectsinbrachytherapybyanelectronemitterophthalmicplaque AT jaberir investigationofgoldnanoparticleeffectsinbrachytherapybyanelectronemitterophthalmicplaque
_version_	1718401455936765952

Investigation of gold nanoparticle effects in brachytherapy by an electron emitter ophthalmic plaque

Ejemplares similares