Keeping an open mind: highlights and controversies of the breast cancer stem cell theory

Mansi Shah,1 Cinzia Allegrucci1,21School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, UK; 2Center for Genetics and Genomics and Cancer Research Nottingham, University of Nottingham, University Park, Nottingham, UKAbstract: The discovery that br...

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Autores principales:	Shah M, Allegrucci C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/bb920c19e1bd48e2954bd1f8235d702a
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spelling	oai:doaj.org-article:bb920c19e1bd48e2954bd1f8235d702a2021-12-02T04:43:31ZKeeping an open mind: highlights and controversies of the breast cancer stem cell theory1179-1314https://doaj.org/article/bb920c19e1bd48e2954bd1f8235d702a2012-10-01T00:00:00Zhttp://www.dovepress.com/keeping-an-open-mind-highlights-and-controversies-of-the-breast-cancer-a11379https://doaj.org/toc/1179-1314Mansi Shah,1 Cinzia Allegrucci1,21School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, UK; 2Center for Genetics and Genomics and Cancer Research Nottingham, University of Nottingham, University Park, Nottingham, UKAbstract: The discovery that breast cancers contain stem-like cells has fuelled exciting research in the last few years. These cells are referred to as breast cancer stem cells (BCSCs) and are thought to be involved in tumor initiation, progression, and metastasis. Being intrinsically resistant to chemo- and radiotherapy, they are also considered responsible for recurrence of the disease after treatment. BCSCs have been suggested to be at the basis of tumor complexity, as they have the ability to self-renew and give rise to highly proliferating and terminally differentiated cancer cells that comprise the heterogeneous bulk of the tumor. There has been much speculation on the BCSC model, and in this review we address some fundamental questions, such as the identity of BCSCs and their involvement in tumor intra- and interheterogeneity. As an alternative to the BCSC model, we discuss clonal evolution, as both theories show extensive evidence in support of their arguments. Finally, we discuss a unifying idea that reconciles both models, which is based on stem cell plasticity and epigenetic modifications induced by the tumor microenvironment. The implications of cancer stem cell plasticity for drug discovery and future therapeutic interventions are presented.Keywords: mammary stem cells, cancer, clonal evolution, plasticity, therapy, epigeneticsShah MAllegrucci CDove Medical PressarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol 2012, Iss default, Pp 155-166 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Shah M Allegrucci C Keeping an open mind: highlights and controversies of the breast cancer stem cell theory
description	Mansi Shah,1 Cinzia Allegrucci1,21School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, UK; 2Center for Genetics and Genomics and Cancer Research Nottingham, University of Nottingham, University Park, Nottingham, UKAbstract: The discovery that breast cancers contain stem-like cells has fuelled exciting research in the last few years. These cells are referred to as breast cancer stem cells (BCSCs) and are thought to be involved in tumor initiation, progression, and metastasis. Being intrinsically resistant to chemo- and radiotherapy, they are also considered responsible for recurrence of the disease after treatment. BCSCs have been suggested to be at the basis of tumor complexity, as they have the ability to self-renew and give rise to highly proliferating and terminally differentiated cancer cells that comprise the heterogeneous bulk of the tumor. There has been much speculation on the BCSC model, and in this review we address some fundamental questions, such as the identity of BCSCs and their involvement in tumor intra- and interheterogeneity. As an alternative to the BCSC model, we discuss clonal evolution, as both theories show extensive evidence in support of their arguments. Finally, we discuss a unifying idea that reconciles both models, which is based on stem cell plasticity and epigenetic modifications induced by the tumor microenvironment. The implications of cancer stem cell plasticity for drug discovery and future therapeutic interventions are presented.Keywords: mammary stem cells, cancer, clonal evolution, plasticity, therapy, epigenetics
format	article
author	Shah M Allegrucci C
author_facet	Shah M Allegrucci C
author_sort	Shah M
title	Keeping an open mind: highlights and controversies of the breast cancer stem cell theory
title_short	Keeping an open mind: highlights and controversies of the breast cancer stem cell theory
title_full	Keeping an open mind: highlights and controversies of the breast cancer stem cell theory
title_fullStr	Keeping an open mind: highlights and controversies of the breast cancer stem cell theory
title_full_unstemmed	Keeping an open mind: highlights and controversies of the breast cancer stem cell theory
title_sort	keeping an open mind: highlights and controversies of the breast cancer stem cell theory
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/bb920c19e1bd48e2954bd1f8235d702a
work_keys_str_mv	AT shahm keepinganopenmindhighlightsandcontroversiesofthebreastcancerstemcelltheory AT allegruccic keepinganopenmindhighlightsandcontroversiesofthebreastcancerstemcelltheory
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Keeping an open mind: highlights and controversies of the breast cancer stem cell theory

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