The protein and mRNA expression levels of glial cell line-derived neurotrophic factor in post stroke depression and major depressive disorder

Abstract Previous studies have indicated that the level of glial cell line-derived neurotrophic factor (GDNF) may be correlated with stroke and depression. Here, we investigated whether GDNF can be a discriminant indicator for post stroke depression (PSD). 159 participants were divided into four gro...

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Autores principales: Yanran Zhang, Haitang Jiang, Yingying Yue, Yingying Yin, Yuqun Zhang, Jinfeng Liang, Shenghua Li, Jun Wang, Jianxin Lu, Deqin Geng, Aiqin Wu, Yonggui Yuan
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Publicado: Nature Portfolio 2017
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spelling oai:doaj.org-article:bb9388a7e21a4ebd97e0cc470f71cd682021-12-02T11:53:09ZThe protein and mRNA expression levels of glial cell line-derived neurotrophic factor in post stroke depression and major depressive disorder10.1038/s41598-017-09000-y2045-2322https://doaj.org/article/bb9388a7e21a4ebd97e0cc470f71cd682017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09000-yhttps://doaj.org/toc/2045-2322Abstract Previous studies have indicated that the level of glial cell line-derived neurotrophic factor (GDNF) may be correlated with stroke and depression. Here, we investigated whether GDNF can be a discriminant indicator for post stroke depression (PSD). 159 participants were divided into four groups: PSD, stroke without depression (Non-PSD), major depressive disorder (MDD) and normal control (NC) group, and the protein and mRNA expression levels of GDNF in serum were measured. The results showed that only MDD group had statistical difference in protein and mRNA levels compared with the other three groups (Bonferroni test, P < 0.05). The results of receiver operating curve (ROC) analysis supported GDNF as general distinguishing models in PSD and MDD groups with the area under the curve (AUC) at 0.797 (P < 0.001) and 0.831 (P < 0.001) respectively. In addition, the Spearman analysis demonstrated that the GDNF protein level negatively correlated with the value of Hamilton depression rating scale (HAMD) in PSD patients (correlation coefficient = −0.328, P = 0.047). Together, these findings suggest the protein and mRNA expression levels of GDNF decreased in patients with depression. GDNF may serve as a potential biomarker for differential diagnosis of PSD from MDD patients.Yanran ZhangHaitang JiangYingying YueYingying YinYuqun ZhangJinfeng LiangShenghua LiJun WangJianxin LuDeqin GengAiqin WuYonggui YuanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Yanran Zhang
Haitang Jiang
Yingying Yue
Yingying Yin
Yuqun Zhang
Jinfeng Liang
Shenghua Li
Jun Wang
Jianxin Lu
Deqin Geng
Aiqin Wu
Yonggui Yuan
The protein and mRNA expression levels of glial cell line-derived neurotrophic factor in post stroke depression and major depressive disorder
description Abstract Previous studies have indicated that the level of glial cell line-derived neurotrophic factor (GDNF) may be correlated with stroke and depression. Here, we investigated whether GDNF can be a discriminant indicator for post stroke depression (PSD). 159 participants were divided into four groups: PSD, stroke without depression (Non-PSD), major depressive disorder (MDD) and normal control (NC) group, and the protein and mRNA expression levels of GDNF in serum were measured. The results showed that only MDD group had statistical difference in protein and mRNA levels compared with the other three groups (Bonferroni test, P < 0.05). The results of receiver operating curve (ROC) analysis supported GDNF as general distinguishing models in PSD and MDD groups with the area under the curve (AUC) at 0.797 (P < 0.001) and 0.831 (P < 0.001) respectively. In addition, the Spearman analysis demonstrated that the GDNF protein level negatively correlated with the value of Hamilton depression rating scale (HAMD) in PSD patients (correlation coefficient = −0.328, P = 0.047). Together, these findings suggest the protein and mRNA expression levels of GDNF decreased in patients with depression. GDNF may serve as a potential biomarker for differential diagnosis of PSD from MDD patients.
format article
author Yanran Zhang
Haitang Jiang
Yingying Yue
Yingying Yin
Yuqun Zhang
Jinfeng Liang
Shenghua Li
Jun Wang
Jianxin Lu
Deqin Geng
Aiqin Wu
Yonggui Yuan
author_facet Yanran Zhang
Haitang Jiang
Yingying Yue
Yingying Yin
Yuqun Zhang
Jinfeng Liang
Shenghua Li
Jun Wang
Jianxin Lu
Deqin Geng
Aiqin Wu
Yonggui Yuan
author_sort Yanran Zhang
title The protein and mRNA expression levels of glial cell line-derived neurotrophic factor in post stroke depression and major depressive disorder
title_short The protein and mRNA expression levels of glial cell line-derived neurotrophic factor in post stroke depression and major depressive disorder
title_full The protein and mRNA expression levels of glial cell line-derived neurotrophic factor in post stroke depression and major depressive disorder
title_fullStr The protein and mRNA expression levels of glial cell line-derived neurotrophic factor in post stroke depression and major depressive disorder
title_full_unstemmed The protein and mRNA expression levels of glial cell line-derived neurotrophic factor in post stroke depression and major depressive disorder
title_sort protein and mrna expression levels of glial cell line-derived neurotrophic factor in post stroke depression and major depressive disorder
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/bb9388a7e21a4ebd97e0cc470f71cd68
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