PRL3 induces polypoid giant cancer cells eliminated by PRL3-zumab to reduce tumor relapse

Thura and colleagues report that PRL3 promotes PGCCs, which are found to be enriched in relapsed tumours. The authors demonstrated that this relapse can be prevented using PRL3-zumab for use in adjuvant immunotherapy to target PRL3-expressing PGCCs, thus preventing metastasis and relapse.

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Autores principales:	Min Thura, Zu Ye, Abdul Qader Al-Aidaroos, Qiancheng Xiong, Jun Yi Ong, Abhishek Gupta, Jie Li, Ke Guo, Koon Hwee Ang, Qi Zeng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/bb95652192f64522bb70e2cd0cf9c272
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:bb95652192f64522bb70e2cd0cf9c2722021-12-02T16:31:01ZPRL3 induces polypoid giant cancer cells eliminated by PRL3-zumab to reduce tumor relapse10.1038/s42003-021-02449-82399-3642https://doaj.org/article/bb95652192f64522bb70e2cd0cf9c2722021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02449-8https://doaj.org/toc/2399-3642Thura and colleagues report that PRL3 promotes PGCCs, which are found to be enriched in relapsed tumours. The authors demonstrated that this relapse can be prevented using PRL3-zumab for use in adjuvant immunotherapy to target PRL3-expressing PGCCs, thus preventing metastasis and relapse.Min ThuraZu YeAbdul Qader Al-AidaroosQiancheng XiongJun Yi OngAbhishek GuptaJie LiKe GuoKoon Hwee AngQi ZengNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Min Thura Zu Ye Abdul Qader Al-Aidaroos Qiancheng Xiong Jun Yi Ong Abhishek Gupta Jie Li Ke Guo Koon Hwee Ang Qi Zeng PRL3 induces polypoid giant cancer cells eliminated by PRL3-zumab to reduce tumor relapse
description	Thura and colleagues report that PRL3 promotes PGCCs, which are found to be enriched in relapsed tumours. The authors demonstrated that this relapse can be prevented using PRL3-zumab for use in adjuvant immunotherapy to target PRL3-expressing PGCCs, thus preventing metastasis and relapse.
format	article
author	Min Thura Zu Ye Abdul Qader Al-Aidaroos Qiancheng Xiong Jun Yi Ong Abhishek Gupta Jie Li Ke Guo Koon Hwee Ang Qi Zeng
author_facet	Min Thura Zu Ye Abdul Qader Al-Aidaroos Qiancheng Xiong Jun Yi Ong Abhishek Gupta Jie Li Ke Guo Koon Hwee Ang Qi Zeng
author_sort	Min Thura
title	PRL3 induces polypoid giant cancer cells eliminated by PRL3-zumab to reduce tumor relapse
title_short	PRL3 induces polypoid giant cancer cells eliminated by PRL3-zumab to reduce tumor relapse
title_full	PRL3 induces polypoid giant cancer cells eliminated by PRL3-zumab to reduce tumor relapse
title_fullStr	PRL3 induces polypoid giant cancer cells eliminated by PRL3-zumab to reduce tumor relapse
title_full_unstemmed	PRL3 induces polypoid giant cancer cells eliminated by PRL3-zumab to reduce tumor relapse
title_sort	prl3 induces polypoid giant cancer cells eliminated by prl3-zumab to reduce tumor relapse
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bb95652192f64522bb70e2cd0cf9c272
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PRL3 induces polypoid giant cancer cells eliminated by PRL3-zumab to reduce tumor relapse

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