PRL3 induces polypoid giant cancer cells eliminated by PRL3-zumab to reduce tumor relapse

Thura and colleagues report that PRL3 promotes PGCCs, which are found to be enriched in relapsed tumours. The authors demonstrated that this relapse can be prevented using PRL3-zumab for use in adjuvant immunotherapy to target PRL3-expressing PGCCs, thus preventing metastasis and relapse.

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Autores principales: Min Thura, Zu Ye, Abdul Qader Al-Aidaroos, Qiancheng Xiong, Jun Yi Ong, Abhishek Gupta, Jie Li, Ke Guo, Koon Hwee Ang, Qi Zeng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/bb95652192f64522bb70e2cd0cf9c272
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