Site specific incidence rate of virulence related genes of enteroaggregative Escherichia coli and association with enteric inflammation and growth in children

Abstract There is a lack of information highlighting the possible association between strain carrying genes of enteroaggregative Escherichia coli (EAEC) and environmental enteric dysfunction (EED) and on linear growth during childhood. Strain carrying genes of EAEC from stool samples collected from...

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Autores principales:	Rina Das, Parag Palit, Md. Ahshanul Haque, Mustafa Mahfuz, A. S. G. Faruque, Tahmeed Ahmed
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bb9c8505cf0a4983a70c3735b1d28ec9
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spelling	oai:doaj.org-article:bb9c8505cf0a4983a70c3735b1d28ec92021-12-05T12:12:53ZSite specific incidence rate of virulence related genes of enteroaggregative Escherichia coli and association with enteric inflammation and growth in children10.1038/s41598-021-02626-z2045-2322https://doaj.org/article/bb9c8505cf0a4983a70c3735b1d28ec92021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02626-zhttps://doaj.org/toc/2045-2322Abstract There is a lack of information highlighting the possible association between strain carrying genes of enteroaggregative Escherichia coli (EAEC) and environmental enteric dysfunction (EED) and on linear growth during childhood. Strain carrying genes of EAEC from stool samples collected from 1705 children enrolled in the MAL-ED birth cohort were detected by TaqMan Array Cards. We measured site-specific incidence rate by using Poisson regression models, identified the risk factors and estimated the associations of strain carrying genes of EAEC with the composite EED score and linear growth at 24 months of age. Overall highest incidence rate (43.3%) was found among children having infection with the aggR gene, which was the greatest in Tanzania (56.7%). Low maternal education, lack of improved floor, and ownership of domestic cattle were found to be risk factors for EAEC infection. In the multivariate models, after adjusting the potential covariates, strain carrying genes of EAEC showed strong positive associations with the EED scores and with poor linear growth at 24 months of age. Our analyses may lay the cornerstone for a prospective epidemiologic investigation for a potential vaccine development aimed at reducing the burden of EAEC infections and combat childhood malnutrition.Rina DasParag PalitMd. Ahshanul HaqueMustafa MahfuzA. S. G. FaruqueTahmeed AhmedNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rina Das Parag Palit Md. Ahshanul Haque Mustafa Mahfuz A. S. G. Faruque Tahmeed Ahmed Site specific incidence rate of virulence related genes of enteroaggregative Escherichia coli and association with enteric inflammation and growth in children
description	Abstract There is a lack of information highlighting the possible association between strain carrying genes of enteroaggregative Escherichia coli (EAEC) and environmental enteric dysfunction (EED) and on linear growth during childhood. Strain carrying genes of EAEC from stool samples collected from 1705 children enrolled in the MAL-ED birth cohort were detected by TaqMan Array Cards. We measured site-specific incidence rate by using Poisson regression models, identified the risk factors and estimated the associations of strain carrying genes of EAEC with the composite EED score and linear growth at 24 months of age. Overall highest incidence rate (43.3%) was found among children having infection with the aggR gene, which was the greatest in Tanzania (56.7%). Low maternal education, lack of improved floor, and ownership of domestic cattle were found to be risk factors for EAEC infection. In the multivariate models, after adjusting the potential covariates, strain carrying genes of EAEC showed strong positive associations with the EED scores and with poor linear growth at 24 months of age. Our analyses may lay the cornerstone for a prospective epidemiologic investigation for a potential vaccine development aimed at reducing the burden of EAEC infections and combat childhood malnutrition.
format	article
author	Rina Das Parag Palit Md. Ahshanul Haque Mustafa Mahfuz A. S. G. Faruque Tahmeed Ahmed
author_facet	Rina Das Parag Palit Md. Ahshanul Haque Mustafa Mahfuz A. S. G. Faruque Tahmeed Ahmed
author_sort	Rina Das
title	Site specific incidence rate of virulence related genes of enteroaggregative Escherichia coli and association with enteric inflammation and growth in children
title_short	Site specific incidence rate of virulence related genes of enteroaggregative Escherichia coli and association with enteric inflammation and growth in children
title_full	Site specific incidence rate of virulence related genes of enteroaggregative Escherichia coli and association with enteric inflammation and growth in children
title_fullStr	Site specific incidence rate of virulence related genes of enteroaggregative Escherichia coli and association with enteric inflammation and growth in children
title_full_unstemmed	Site specific incidence rate of virulence related genes of enteroaggregative Escherichia coli and association with enteric inflammation and growth in children
title_sort	site specific incidence rate of virulence related genes of enteroaggregative escherichia coli and association with enteric inflammation and growth in children
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bb9c8505cf0a4983a70c3735b1d28ec9
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Site specific incidence rate of virulence related genes of enteroaggregative Escherichia coli and association with enteric inflammation and growth in children

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