Improved Biomedical Properties of Polydopamine-Coated Carbon Nanotubes

Carbon nanotubes (CNTs) due to their outstanding mechanical, thermal, chemical, and optical properties were utilized as a base material and were coated with polydopamine (PDA) (PDA@CNT) via the simple self-polymerization of dopamine (DA). Then, PDA@CNT coatings of up to five layers were examined for...

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Autores principales:	Sahin Demirci, Mehtap Sahiner, Selin Sagbas Suner, Nurettin Sahiner
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	carbon nanotubes polydopamine biomedical coating PDA@CNT Mechanical engineering and machinery TJ1-1570
Acceso en línea:	https://doaj.org/article/bb9cbed6d4e84a4cb188e983425b4995
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spelling	oai:doaj.org-article:bb9cbed6d4e84a4cb188e983425b49952021-11-25T18:22:44ZImproved Biomedical Properties of Polydopamine-Coated Carbon Nanotubes10.3390/mi121112802072-666Xhttps://doaj.org/article/bb9cbed6d4e84a4cb188e983425b49952021-10-01T00:00:00Zhttps://www.mdpi.com/2072-666X/12/11/1280https://doaj.org/toc/2072-666XCarbon nanotubes (CNTs) due to their outstanding mechanical, thermal, chemical, and optical properties were utilized as a base material and were coated with polydopamine (PDA) (PDA@CNT) via the simple self-polymerization of dopamine (DA). Then, PDA@CNT coatings of up to five layers were examined for potential biomedical applications. The success of multiple coating of CNTs with PDA was confirmed via increased weight loss values with the increased number of PDA coatings of CNTs at 500 °C by thermogravimetric analysis. The surface area of bare CNTs was measured as 263.9 m<sup>2</sup>/g and decreased to 197.0 m<sup>2</sup>/g after a 5th coating with PDA. Furthermore, the antioxidant activities of CNT and PDA@CNTs were determined via total flavonoid content (TFC), total phenol content (TPC), and Fe(III)-reducing antioxidant power (FRAP) tests, revealing the increased antioxidant ability of PDA@CNTs with the increasing numbers of PDA coatings. Moreover, a higher inhibition percentage of the activity of the alpha-glucosidase enzyme with 95.1 ± 2.9% inhibition at 6 mg/mL PDA-1st@CNTs concentration was found. The CNT and PDA@CNTs exhibited blood compatibility, less than a 2.5% hemolysis ratio, and more than 85% blood clotting indexes. The minimum inhibition concentration (MIC) of PDA-5th@CNTs against <i>E. coli</i> and <i>S. aureus</i> bacteria was determined as 10 mg/mL.Sahin DemirciMehtap SahinerSelin Sagbas SunerNurettin SahinerMDPI AGarticlecarbon nanotubespolydopaminebiomedicalcoatingPDA@CNTMechanical engineering and machineryTJ1-1570ENMicromachines, Vol 12, Iss 1280, p 1280 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	carbon nanotubes polydopamine biomedical coating PDA@CNT Mechanical engineering and machinery TJ1-1570
spellingShingle	carbon nanotubes polydopamine biomedical coating PDA@CNT Mechanical engineering and machinery TJ1-1570 Sahin Demirci Mehtap Sahiner Selin Sagbas Suner Nurettin Sahiner Improved Biomedical Properties of Polydopamine-Coated Carbon Nanotubes
description	Carbon nanotubes (CNTs) due to their outstanding mechanical, thermal, chemical, and optical properties were utilized as a base material and were coated with polydopamine (PDA) (PDA@CNT) via the simple self-polymerization of dopamine (DA). Then, PDA@CNT coatings of up to five layers were examined for potential biomedical applications. The success of multiple coating of CNTs with PDA was confirmed via increased weight loss values with the increased number of PDA coatings of CNTs at 500 °C by thermogravimetric analysis. The surface area of bare CNTs was measured as 263.9 m<sup>2</sup>/g and decreased to 197.0 m<sup>2</sup>/g after a 5th coating with PDA. Furthermore, the antioxidant activities of CNT and PDA@CNTs were determined via total flavonoid content (TFC), total phenol content (TPC), and Fe(III)-reducing antioxidant power (FRAP) tests, revealing the increased antioxidant ability of PDA@CNTs with the increasing numbers of PDA coatings. Moreover, a higher inhibition percentage of the activity of the alpha-glucosidase enzyme with 95.1 ± 2.9% inhibition at 6 mg/mL PDA-1st@CNTs concentration was found. The CNT and PDA@CNTs exhibited blood compatibility, less than a 2.5% hemolysis ratio, and more than 85% blood clotting indexes. The minimum inhibition concentration (MIC) of PDA-5th@CNTs against <i>E. coli</i> and <i>S. aureus</i> bacteria was determined as 10 mg/mL.
format	article
author	Sahin Demirci Mehtap Sahiner Selin Sagbas Suner Nurettin Sahiner
author_facet	Sahin Demirci Mehtap Sahiner Selin Sagbas Suner Nurettin Sahiner
author_sort	Sahin Demirci
title	Improved Biomedical Properties of Polydopamine-Coated Carbon Nanotubes
title_short	Improved Biomedical Properties of Polydopamine-Coated Carbon Nanotubes
title_full	Improved Biomedical Properties of Polydopamine-Coated Carbon Nanotubes
title_fullStr	Improved Biomedical Properties of Polydopamine-Coated Carbon Nanotubes
title_full_unstemmed	Improved Biomedical Properties of Polydopamine-Coated Carbon Nanotubes
title_sort	improved biomedical properties of polydopamine-coated carbon nanotubes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bb9cbed6d4e84a4cb188e983425b4995
work_keys_str_mv	AT sahindemirci improvedbiomedicalpropertiesofpolydopaminecoatedcarbonnanotubes AT mehtapsahiner improvedbiomedicalpropertiesofpolydopaminecoatedcarbonnanotubes AT selinsagbassuner improvedbiomedicalpropertiesofpolydopaminecoatedcarbonnanotubes AT nurettinsahiner improvedbiomedicalpropertiesofpolydopaminecoatedcarbonnanotubes
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Improved Biomedical Properties of Polydopamine-Coated Carbon Nanotubes

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