Reduced prefrontal cortex activation using the Trail Making Test in schizophrenia

Ryo Fujiki,1,2 Kiichiro Morita,1,2 Mamoru Sato,1,2 Yuji Kamada,1,2 Yusuke Kato,1,2 Masayuki Inoue,2 Yoshihisa Shoji,1,2 Naohisa Uchimura1 1Department of Neuropsychiatry, Kurume University School of Medicine, Kurume-City, Japan; 2Cognitive and Molecular Research Institute of Brain Diseases, Kurume Un...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fujiki R, Morita K, Sato M, Kamada Y, Kato Y, Inoue M, Shoji Y, Uchimura N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/bb9e2ece5cdc4eea92fa3d05a464148a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bb9e2ece5cdc4eea92fa3d05a464148a
record_format	dspace
spelling	oai:doaj.org-article:bb9e2ece5cdc4eea92fa3d05a464148a2021-12-02T03:11:56ZReduced prefrontal cortex activation using the Trail Making Test in schizophrenia1176-63281178-2021https://doaj.org/article/bb9e2ece5cdc4eea92fa3d05a464148a2013-05-01T00:00:00Zhttp://www.dovepress.com/reduced-prefrontal-cortex-activation-using-the-trail-making-test-in-sc-a13071https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Ryo Fujiki,1,2 Kiichiro Morita,1,2 Mamoru Sato,1,2 Yuji Kamada,1,2 Yusuke Kato,1,2 Masayuki Inoue,2 Yoshihisa Shoji,1,2 Naohisa Uchimura1 1Department of Neuropsychiatry, Kurume University School of Medicine, Kurume-City, Japan; 2Cognitive and Molecular Research Institute of Brain Diseases, Kurume University School of Medicine, Kurume-City, Japan Abstract: Schizophrenia has been associated with a deficit of the prefrontal cortex, which is involved in attention, executive processes, and working memory. The Trail Making Test (TMT) is administered in two parts, TMT-A and TMT-B. It is suggested that the difference in performance between part A and part B reflects executive processes. In this study, we compared the characteristics of hemodynamic changes during TMT tasks between 14 outpatients with schizophrenia and 14 age- and gender-matched healthy control subjects. Using multichannel near-infrared spectroscopy, we measured relative changes in oxygenated hemoglobin concentration, which reflects brain activity of the prefrontal cortex during this task. In both tasks, patients showed significantly smaller activation than controls and, in an assessment of executive functions, a subtraction of oxygenated hemoglobin (oxy-Hb) changes during TMT-A from those of TMT-B showed a decrease in cerebral lateralization and hypoactivity in patients. There was a significant negative correlation between oxy-Hb changes and the severity of psychiatric symptoms. These findings may characterize disease-related features, suggesting the usefulness of oxy-Hb change measurement during TMT tasks for assessing functional outcomes in schizophrenic patients. Keywords: Trail Making Test, multichannel near-infrared spectroscopy, schizophrenia, prefrontal cortex, executive functionFujiki RMorita KSato MKamada YKato YInoue MShoji YUchimura NDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 675-685 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Fujiki R Morita K Sato M Kamada Y Kato Y Inoue M Shoji Y Uchimura N Reduced prefrontal cortex activation using the Trail Making Test in schizophrenia
description	Ryo Fujiki,1,2 Kiichiro Morita,1,2 Mamoru Sato,1,2 Yuji Kamada,1,2 Yusuke Kato,1,2 Masayuki Inoue,2 Yoshihisa Shoji,1,2 Naohisa Uchimura1 1Department of Neuropsychiatry, Kurume University School of Medicine, Kurume-City, Japan; 2Cognitive and Molecular Research Institute of Brain Diseases, Kurume University School of Medicine, Kurume-City, Japan Abstract: Schizophrenia has been associated with a deficit of the prefrontal cortex, which is involved in attention, executive processes, and working memory. The Trail Making Test (TMT) is administered in two parts, TMT-A and TMT-B. It is suggested that the difference in performance between part A and part B reflects executive processes. In this study, we compared the characteristics of hemodynamic changes during TMT tasks between 14 outpatients with schizophrenia and 14 age- and gender-matched healthy control subjects. Using multichannel near-infrared spectroscopy, we measured relative changes in oxygenated hemoglobin concentration, which reflects brain activity of the prefrontal cortex during this task. In both tasks, patients showed significantly smaller activation than controls and, in an assessment of executive functions, a subtraction of oxygenated hemoglobin (oxy-Hb) changes during TMT-A from those of TMT-B showed a decrease in cerebral lateralization and hypoactivity in patients. There was a significant negative correlation between oxy-Hb changes and the severity of psychiatric symptoms. These findings may characterize disease-related features, suggesting the usefulness of oxy-Hb change measurement during TMT tasks for assessing functional outcomes in schizophrenic patients. Keywords: Trail Making Test, multichannel near-infrared spectroscopy, schizophrenia, prefrontal cortex, executive function
format	article
author	Fujiki R Morita K Sato M Kamada Y Kato Y Inoue M Shoji Y Uchimura N
author_facet	Fujiki R Morita K Sato M Kamada Y Kato Y Inoue M Shoji Y Uchimura N
author_sort	Fujiki R
title	Reduced prefrontal cortex activation using the Trail Making Test in schizophrenia
title_short	Reduced prefrontal cortex activation using the Trail Making Test in schizophrenia
title_full	Reduced prefrontal cortex activation using the Trail Making Test in schizophrenia
title_fullStr	Reduced prefrontal cortex activation using the Trail Making Test in schizophrenia
title_full_unstemmed	Reduced prefrontal cortex activation using the Trail Making Test in schizophrenia
title_sort	reduced prefrontal cortex activation using the trail making test in schizophrenia
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/bb9e2ece5cdc4eea92fa3d05a464148a
work_keys_str_mv	AT fujikir reducedprefrontalcortexactivationusingthetrailmakingtestinschizophrenia AT moritak reducedprefrontalcortexactivationusingthetrailmakingtestinschizophrenia AT satom reducedprefrontalcortexactivationusingthetrailmakingtestinschizophrenia AT kamaday reducedprefrontalcortexactivationusingthetrailmakingtestinschizophrenia AT katoy reducedprefrontalcortexactivationusingthetrailmakingtestinschizophrenia AT inouem reducedprefrontalcortexactivationusingthetrailmakingtestinschizophrenia AT shojiy reducedprefrontalcortexactivationusingthetrailmakingtestinschizophrenia AT uchimuran reducedprefrontalcortexactivationusingthetrailmakingtestinschizophrenia
_version_	1718401879852974080

Reduced prefrontal cortex activation using the Trail Making Test in schizophrenia

Ejemplares similares