Comparative study on the effect of EGCG and wheat grass together with mental and physical activities against induction of Alzheimer's disease in both isolated and socialized rats

Background: Alzheimer's disease (AD) is the most common cause of dementia where symptoms gradually deteriorate over years. We previously reported that social isolation exacerbates memory loss while mental and physical activities maintain cognitive functions. Epigallocatechin-3-gallate (EGCG), a...

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Autores principales:	Mona G. Khalil, Azza A. Ali, Soha Osama Hassanin, Aya H. Al-Najjar, Soumya Ghosh, Maha Osama Mahmoud
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Alzheimer's Epigallocatechin-3-gallate Wheatgrass Mental Physical Isolation Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/bba0a8be28c74d30a140c48a261075c2
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spelling	oai:doaj.org-article:bba0a8be28c74d30a140c48a261075c22021-11-14T04:36:09ZComparative study on the effect of EGCG and wheat grass together with mental and physical activities against induction of Alzheimer's disease in both isolated and socialized rats2667-031310.1016/j.phyplu.2021.100146https://doaj.org/article/bba0a8be28c74d30a140c48a261075c22022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667031321001287https://doaj.org/toc/2667-0313Background: Alzheimer's disease (AD) is the most common cause of dementia where symptoms gradually deteriorate over years. We previously reported that social isolation exacerbates memory loss while mental and physical activities maintain cognitive functions. Epigallocatechin-3-gallate (EGCG), a natural chelator, and wheatgrass, natural antioxidant could provide CNS health-promoting effects. Purpose: The study aimed to investigate the combined effects of EGCG and wheatgrass together with mental and physical activities against AD in socialized and isolated conditions. Study design: Rats were classified into socialized and corresponding isolated groups. Methodology: Eight groups of rats (4 socialized and 4 isolated) were exposed to mental and physical activities using Swimming test and Y-maze (each for one time/week) during four weeks of the experiment. Two groups of both socialized and isolated were normal while the others (AD model) received daily AlCl3 (70 mg/kg IP). Normal and AD model groups received also either saline for control or EGCG (10 mg/kg every other day IP) & wheat grass (100 mg/kg PO daily) for treated groups. The brain Aβ, AChE, monoamines, inflammatory mediators, oxidative parameters and brain derived neurotrophic factor (BDNF) were measured. Histopathological examination of brain sections was also conducted. Results: Brain neurological damage is more severe in isolation-associated AD. Treatment of EGCG and wheatgrass together with mental and physical activities (Ph & M) showed higher protection against hazards of AlCl3 and isolation than mental & physical activities alone especially in isolated groups. Their protection was indicated by the significant decrease in Aβ, AChE, MDA, TNF-α, IL-1β together with the increase in SOD, TAC, brain monoamines, BDNF which confirmed by improvement in histopathological pictures of brain sections. Conclusion: It was concluded that, EGCG and wheatgrass together with mental and physical activities can protect against neuronal degenerations associated with the development of AD particularly in social isolated conditions than mental and physical activities alone.Mona G. KhalilAzza A. AliSoha Osama HassaninAya H. Al-NajjarSoumya GhoshMaha Osama MahmoudElsevierarticleAlzheimer'sEpigallocatechin-3-gallateWheatgrassMentalPhysicalIsolationOther systems of medicineRZ201-999ENPhytomedicine Plus, Vol 2, Iss 1, Pp 100146- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer's Epigallocatechin-3-gallate Wheatgrass Mental Physical Isolation Other systems of medicine RZ201-999
spellingShingle	Alzheimer's Epigallocatechin-3-gallate Wheatgrass Mental Physical Isolation Other systems of medicine RZ201-999 Mona G. Khalil Azza A. Ali Soha Osama Hassanin Aya H. Al-Najjar Soumya Ghosh Maha Osama Mahmoud Comparative study on the effect of EGCG and wheat grass together with mental and physical activities against induction of Alzheimer's disease in both isolated and socialized rats
description	Background: Alzheimer's disease (AD) is the most common cause of dementia where symptoms gradually deteriorate over years. We previously reported that social isolation exacerbates memory loss while mental and physical activities maintain cognitive functions. Epigallocatechin-3-gallate (EGCG), a natural chelator, and wheatgrass, natural antioxidant could provide CNS health-promoting effects. Purpose: The study aimed to investigate the combined effects of EGCG and wheatgrass together with mental and physical activities against AD in socialized and isolated conditions. Study design: Rats were classified into socialized and corresponding isolated groups. Methodology: Eight groups of rats (4 socialized and 4 isolated) were exposed to mental and physical activities using Swimming test and Y-maze (each for one time/week) during four weeks of the experiment. Two groups of both socialized and isolated were normal while the others (AD model) received daily AlCl3 (70 mg/kg IP). Normal and AD model groups received also either saline for control or EGCG (10 mg/kg every other day IP) & wheat grass (100 mg/kg PO daily) for treated groups. The brain Aβ, AChE, monoamines, inflammatory mediators, oxidative parameters and brain derived neurotrophic factor (BDNF) were measured. Histopathological examination of brain sections was also conducted. Results: Brain neurological damage is more severe in isolation-associated AD. Treatment of EGCG and wheatgrass together with mental and physical activities (Ph & M) showed higher protection against hazards of AlCl3 and isolation than mental & physical activities alone especially in isolated groups. Their protection was indicated by the significant decrease in Aβ, AChE, MDA, TNF-α, IL-1β together with the increase in SOD, TAC, brain monoamines, BDNF which confirmed by improvement in histopathological pictures of brain sections. Conclusion: It was concluded that, EGCG and wheatgrass together with mental and physical activities can protect against neuronal degenerations associated with the development of AD particularly in social isolated conditions than mental and physical activities alone.
format	article
author	Mona G. Khalil Azza A. Ali Soha Osama Hassanin Aya H. Al-Najjar Soumya Ghosh Maha Osama Mahmoud
author_facet	Mona G. Khalil Azza A. Ali Soha Osama Hassanin Aya H. Al-Najjar Soumya Ghosh Maha Osama Mahmoud
author_sort	Mona G. Khalil
title	Comparative study on the effect of EGCG and wheat grass together with mental and physical activities against induction of Alzheimer's disease in both isolated and socialized rats
title_short	Comparative study on the effect of EGCG and wheat grass together with mental and physical activities against induction of Alzheimer's disease in both isolated and socialized rats
title_full	Comparative study on the effect of EGCG and wheat grass together with mental and physical activities against induction of Alzheimer's disease in both isolated and socialized rats
title_fullStr	Comparative study on the effect of EGCG and wheat grass together with mental and physical activities against induction of Alzheimer's disease in both isolated and socialized rats
title_full_unstemmed	Comparative study on the effect of EGCG and wheat grass together with mental and physical activities against induction of Alzheimer's disease in both isolated and socialized rats
title_sort	comparative study on the effect of egcg and wheat grass together with mental and physical activities against induction of alzheimer's disease in both isolated and socialized rats
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/bba0a8be28c74d30a140c48a261075c2
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Comparative study on the effect of EGCG and wheat grass together with mental and physical activities against induction of Alzheimer's disease in both isolated and socialized rats

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