COMMON MECHANISMS OF SPECIFIC HUMORAL IMMUNE RESPONSE’ SHAPING AND SUSTAINING BY THE EXAMPLE OF IMMUNE RESPONSE TO MEASLES AND RUBELLA VIRUSES

Abstract. T follicular helper cells (Tfh) are a CD4+ Th cell subset promoted the cognate control of antigen-specific B cell immunity. Upon first contact with antigen-primed B cells, Tfh can support either extrafollicularly differentiation into short-lived plasma cells (PC) or enter follicles to form...

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Autor principal:	A. P. Toptygina
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	specific humoral immune response t follicular helper igg subclasses slam measles rubella Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/bba47ca969fa4de6bdbf1ce95096ae96
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spelling	oai:doaj.org-article:bba47ca969fa4de6bdbf1ce95096ae962021-11-22T07:09:46ZCOMMON MECHANISMS OF SPECIFIC HUMORAL IMMUNE RESPONSE’ SHAPING AND SUSTAINING BY THE EXAMPLE OF IMMUNE RESPONSE TO MEASLES AND RUBELLA VIRUSES2220-76192313-739810.15789/2220-7619-2014-1-7-14https://doaj.org/article/bba47ca969fa4de6bdbf1ce95096ae962014-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/152https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. T follicular helper cells (Tfh) are a CD4+ Th cell subset promoted the cognate control of antigen-specific B cell immunity. Upon first contact with antigen-primed B cells, Tfh can support either extrafollicularly differentiation into short-lived plasma cells (PC) or enter follicles to form germinal centers (GC). Signaling lymphocytic activation molecule (SLAM) interaction between Tfh and activated B-cells is essential for GC development. Within GC, Tfh regulates the fate of antigen-specific GC B cells expressing high-affinity B cell receptors to develop memory B cell (Bm) or long-lived PC. Short-lived PC produce low-affinity IgM and IgG3 early antibodies. Both Bm and long-lived PC have high-affinity class-switched IgA and IgG, predominantly IgG1 antibodies. Measles virus uses human SLAM-molecule as a cellular receptor. SLAM is expressed on dendritic cells and activated B and T-cells. This is an important regulator of the isotype switching and antibody affinity maturation, especially IgG3-IgG1 switching. Development of long-term humoral immunity, charac terized by the formation of high-affinity predominantly IgG1 antibodies, is a critical component of protective immunity to pathogens and the major goal of vaccination. However, the mechanisms involved in the shaping and sustaining of long-term humoral immunity remain poorly understood.A. P. ToptyginaSankt-Peterburg : NIIÈM imeni Pasteraarticlespecific humoral immune responset follicular helperigg subclassesslammeaslesrubellaInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 4, Iss 1, Pp 7-14 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	specific humoral immune response t follicular helper igg subclasses slam measles rubella Infectious and parasitic diseases RC109-216
spellingShingle	specific humoral immune response t follicular helper igg subclasses slam measles rubella Infectious and parasitic diseases RC109-216 A. P. Toptygina COMMON MECHANISMS OF SPECIFIC HUMORAL IMMUNE RESPONSE’ SHAPING AND SUSTAINING BY THE EXAMPLE OF IMMUNE RESPONSE TO MEASLES AND RUBELLA VIRUSES
description	Abstract. T follicular helper cells (Tfh) are a CD4+ Th cell subset promoted the cognate control of antigen-specific B cell immunity. Upon first contact with antigen-primed B cells, Tfh can support either extrafollicularly differentiation into short-lived plasma cells (PC) or enter follicles to form germinal centers (GC). Signaling lymphocytic activation molecule (SLAM) interaction between Tfh and activated B-cells is essential for GC development. Within GC, Tfh regulates the fate of antigen-specific GC B cells expressing high-affinity B cell receptors to develop memory B cell (Bm) or long-lived PC. Short-lived PC produce low-affinity IgM and IgG3 early antibodies. Both Bm and long-lived PC have high-affinity class-switched IgA and IgG, predominantly IgG1 antibodies. Measles virus uses human SLAM-molecule as a cellular receptor. SLAM is expressed on dendritic cells and activated B and T-cells. This is an important regulator of the isotype switching and antibody affinity maturation, especially IgG3-IgG1 switching. Development of long-term humoral immunity, charac terized by the formation of high-affinity predominantly IgG1 antibodies, is a critical component of protective immunity to pathogens and the major goal of vaccination. However, the mechanisms involved in the shaping and sustaining of long-term humoral immunity remain poorly understood.
format	article
author	A. P. Toptygina
author_facet	A. P. Toptygina
author_sort	A. P. Toptygina
title	COMMON MECHANISMS OF SPECIFIC HUMORAL IMMUNE RESPONSE’ SHAPING AND SUSTAINING BY THE EXAMPLE OF IMMUNE RESPONSE TO MEASLES AND RUBELLA VIRUSES
title_short	COMMON MECHANISMS OF SPECIFIC HUMORAL IMMUNE RESPONSE’ SHAPING AND SUSTAINING BY THE EXAMPLE OF IMMUNE RESPONSE TO MEASLES AND RUBELLA VIRUSES
title_full	COMMON MECHANISMS OF SPECIFIC HUMORAL IMMUNE RESPONSE’ SHAPING AND SUSTAINING BY THE EXAMPLE OF IMMUNE RESPONSE TO MEASLES AND RUBELLA VIRUSES
title_fullStr	COMMON MECHANISMS OF SPECIFIC HUMORAL IMMUNE RESPONSE’ SHAPING AND SUSTAINING BY THE EXAMPLE OF IMMUNE RESPONSE TO MEASLES AND RUBELLA VIRUSES
title_full_unstemmed	COMMON MECHANISMS OF SPECIFIC HUMORAL IMMUNE RESPONSE’ SHAPING AND SUSTAINING BY THE EXAMPLE OF IMMUNE RESPONSE TO MEASLES AND RUBELLA VIRUSES
title_sort	common mechanisms of specific humoral immune response’ shaping and sustaining by the example of immune response to measles and rubella viruses
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/bba47ca969fa4de6bdbf1ce95096ae96
work_keys_str_mv	AT aptoptygina commonmechanismsofspecifichumoralimmuneresponseshapingandsustainingbytheexampleofimmuneresponsetomeaslesandrubellaviruses
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COMMON MECHANISMS OF SPECIFIC HUMORAL IMMUNE RESPONSE’ SHAPING AND SUSTAINING BY THE EXAMPLE OF IMMUNE RESPONSE TO MEASLES AND RUBELLA VIRUSES

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